INT42832

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.36
First Reported 1982
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 7
Disease Relevance 0.96
Pain Relevance 6.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (OPRM1) endoplasmic reticulum (OPRM1) plasma membrane (OPRM1)
signal transducer activity (OPRM1)
Anatomy Link Frequency
pyramidal cells 2
proximal 2
OPRM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
opioid receptor 262 100.00 Very High Very High Very High
Opioid 32 100.00 Very High Very High Very High
mu opioid receptor 16 100.00 Very High Very High Very High
opiate 11 100.00 Very High Very High Very High
narcan 7 99.98 Very High Very High Very High
Pyramidal cell 3 99.96 Very High Very High Very High
Endogenous opioid 5 98.68 Very High Very High Very High
agonist 30 98.52 Very High Very High Very High
antagonist 78 98.22 Very High Very High Very High
Enkephalin 21 97.98 Very High Very High Very High
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 5 95.60 Very High Very High Very High
Nociception 15 76.40 Quite High
Leukemia 1 75.12 Quite High
Urological Neuroanatomy 1 70.44 Quite High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

30 69.72 Quite High
Drug Dependence 1 68.84 Quite High
Pain 23 68.08 Quite High
INFLAMMATION 1 66.88 Quite High
Infection 1 51.76 Quite High
Opiate Addiction 1 48.04 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The 35-bp sequence (-694 to -660) was the hMOR homolog of the mMOR negative regulatory element, and it suppressed proximal promoter activity of the hMOR gene.
Negative_regulation (suppressed) of Positive_regulation (activity) of hMOR in proximal
1) Confidence 0.36 Published 2001 Journal DNA Cell Biol. Section Abstract Doc Link 11506703 Disease Relevance 0.21 Pain Relevance 0.46
Induction of 5-HT(2A) receptor expression in these cells resulted in up-regulation of mu opioid peptide receptor levels that was blocked by both a 5-HT(2A) receptor inverse agonist and selective inhibition of signaling via Galpha(q)/Galpha(11) G proteins.
Negative_regulation (blocked) of Positive_regulation (up-regulation) of mu opioid peptide receptor associated with agonist and opioid
2) Confidence 0.35 Published 2008 Journal Mol. Pharmacol. Section Abstract Doc Link 18703670 Disease Relevance 0.07 Pain Relevance 1.68
Treatment with TNF-alpha neutralizing antibody, as well as blockage of TNF-alpha's actions by anti-TNF-alpha receptor type II (TNFR-II) antibody, inhibited gp120-induced up-regulation of MOR mRNA.
Negative_regulation (inhibited) of Positive_regulation (up-regulation) of MOR mRNA associated with mu opioid receptor
3) Confidence 0.35 Published 2006 Journal Int. Immunopharmacol. Section Abstract Doc Link 16846840 Disease Relevance 0.55 Pain Relevance 0.60
Growth hormone, prolactin and cortisol nyctohemeral variations during naloxone-induced opiate receptor blockade in man.
Negative_regulation (blockade) of Positive_regulation (induced) of opiate receptor associated with narcan and opiate
4) Confidence 0.15 Published 1982 Journal Acta Endocrinol. Section Title Doc Link 6287782 Disease Relevance 0 Pain Relevance 0.81
CTAP completely blocks MOR internalization induced by DAMGO while, in contrast, it partially inhibits MOR internalization induced by hydrogen sulphide.
Negative_regulation (inhibits) of Positive_regulation (induced) of MOR associated with antagonist and opioid receptor
5) Confidence 0.07 Published 2010 Journal Mol Pain Section Body Doc Link PMC2908066 Disease Relevance 0 Pain Relevance 1.15
Thus not only SKNMCs express SUR1 and Kir6.2, but blocking these channels with glibenclamide abrogates AKT phosphorylation and MOR activation and internalization induced by H2S.
Negative_regulation (abrogates) of Positive_regulation (activation) of MOR associated with opioid receptor
6) Confidence 0.07 Published 2010 Journal Mol Pain Section Body Doc Link PMC2908066 Disease Relevance 0 Pain Relevance 0.54
5-Hydroxytryptamine-induced excitatory postsynaptic currents in neocortical layer V pyramidal cells: suppression by mu-opiate receptor activation.
Negative_regulation (suppression) of Positive_regulation (activation) of mu-opiate receptor in pyramidal cells associated with pyramidal cell, enkephalin and opiate
7) Confidence 0.02 Published 1998 Journal Neuroscience Section Title Doc Link 9881863 Disease Relevance 0 Pain Relevance 1.11

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox