INT42833

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Context Info
Confidence 0.48
First Reported 1982
Last Reported 2006
Negated 1
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 0.12
Pain Relevance 4.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (OPRM1) endoplasmic reticulum (OPRM1) plasma membrane (OPRM1)
signal transducer activity (OPRM1)
OPRM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
opioid receptor 32 100.00 Very High Very High Very High
Kinase C 29 100.00 Very High Very High Very High
agonist 17 100.00 Very High Very High Very High
Enkephalin 7 100.00 Very High Very High Very High
opiate 4 100.00 Very High Very High Very High
Analgesic 1 100.00 Very High Very High Very High
narcan 7 99.98 Very High Very High Very High
Immobilon 6 99.48 Very High Very High Very High
Morphine 15 98.96 Very High Very High Very High
Endogenous opioid 1 98.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Neuroblastoma 4 66.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
But the desensitization rate was increased by reduction of the mu-opioid receptor level with beta-furnaltrexamine (betaFNA).
Positive_regulation (increased) of Negative_regulation (reduction) of mu-opioid receptor associated with opioid receptor
1) Confidence 0.48 Published 2000 Journal Mol. Pharmacol. Section Abstract Doc Link 10908307 Disease Relevance 0.05 Pain Relevance 0.39
Expression of a dominant negative mutant G protein-coupled receptor kinase 2 (GRK2), GRK2-K220R, markedly attenuated the DAMGO-induced desensitization of MOR1, but it had no effect on morphine-induced MOR1 desensitization.
Positive_regulation (induced) of Negative_regulation (desensitization) of MOR1 associated with morphine
2) Confidence 0.47 Published 2006 Journal Mol. Pharmacol. Section Abstract Doc Link 16682505 Disease Relevance 0 Pain Relevance 1.50
However, others have suggested that receptor phosphorylation is the trigger for mu-opioid receptor desensitization.
Positive_regulation (trigger) of Negative_regulation (desensitization) of mu-opioid receptor associated with opioid receptor
3) Confidence 0.45 Published 2000 Journal Mol. Pharmacol. Section Abstract Doc Link 10908307 Disease Relevance 0 Pain Relevance 0.32
Sequestration and rapid down-regulation of the mu-opioid receptor were induced by DAGO and etorphine but not morphine.
Neg (not) Positive_regulation (induced) of Negative_regulation (down-regulation) of mu-opioid receptor associated with opioid receptor, morphine and immobilon
4) Confidence 0.44 Published 1997 Journal FEBS Lett. Section Abstract Doc Link 9350996 Disease Relevance 0 Pain Relevance 0.74
Growth hormone, prolactin and cortisol nyctohemeral variations during naloxone-induced opiate receptor blockade in man.
Positive_regulation (induced) of Negative_regulation (blockade) of opiate receptor associated with narcan and opiate
5) Confidence 0.16 Published 1982 Journal Acta Endocrinol. Section Title Doc Link 6287782 Disease Relevance 0 Pain Relevance 0.81
Role of protein kinase C (PKC) in agonist-induced mu-opioid receptor down-regulation: II.
Positive_regulation (Role) of Negative_regulation (regulation) of mu-opioid receptor associated with kinase c, analgesic, agonist and opioid receptor
6) Confidence 0.12 Published 1999 Journal J. Neurochem. Section Title Doc Link 9930731 Disease Relevance 0.07 Pain Relevance 1.18

General Comments

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