INT4284

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Context Info
Confidence 0.43
First Reported 1976
Last Reported 2010
Negated 2
Speculated 5
Reported most in Abstract
Documents 17
Total Number 25
Disease Relevance 8.17
Pain Relevance 7.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lyase activity (Ddc) intracellular (Ddc) cellular amino acid metabolic process (Ddc)
cytoplasm (Ddc)
Anatomy Link Frequency
striatum 3
substantia nigra 2
plasma 1
medulla 1
brain 1
Ddc (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 106 100.00 Very High Very High Very High
Neurotransmitter 35 100.00 Very High Very High Very High
antagonist 28 100.00 Very High Very High Very High
Pain 13 100.00 Very High Very High Very High
Enkephalin 12 100.00 Very High Very High Very High
Serotonin 9 100.00 Very High Very High Very High
Nicotine 13 99.82 Very High Very High Very High
medulla 17 99.44 Very High Very High Very High
Locus ceruleus 1 99.40 Very High Very High Very High
Substantia nigra 18 98.64 Very High Very High Very High
Disease Link Frequency Relevance Heat
Disease 137 100.00 Very High Very High Very High
Peripheral Neuropathy 10 99.82 Very High Very High Very High
Repression 8 99.76 Very High Very High Very High
Injury 43 99.40 Very High Very High Very High
Neuropathic Pain 19 99.26 Very High Very High Very High
Cognitive Disorder 4 99.24 Very High Very High Very High
Hypersensitivity 8 99.04 Very High Very High Very High
Hypertension 15 98.44 Very High Very High Very High
Hyperalgesia 6 98.24 Very High Very High Very High
Dyskinesias 44 96.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This study examined the acute effects of a variety of NMDA and non-NMDA antagonists on the activity of aromatic l-amino acid decarboxylase (AADC) in the corpus striatum (CS) and substantia nigra (SN) of the rat.
Spec (examined) Regulation (effects) of AADC in substantia nigra associated with substantia nigra and antagonist
1) Confidence 0.43 Published 1998 Journal Brain Res. Section Abstract Doc Link 9593857 Disease Relevance 0 Pain Relevance 0.46
The mechanism controlling Ddc mRNA repression following pyrethroid exposure is unclear, but provides support that monoaminergic neurotransmitter systems are sensitive to the compounds.
Regulation (controlling) of Ddc associated with neurotransmitter, repression and monoamine
2) Confidence 0.42 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2626604 Disease Relevance 0.24 Pain Relevance 0.49
Further investigation of the bioenergetics' status of the denervated striatum revealed significant changes in the levels of creatine both after L-DOPA alone and with the supplemented diet.
Regulation (changes) of L-DOPA in striatum
3) Confidence 0.42 Published 2009 Journal Behav. Brain Res. Section Abstract Doc Link 18762218 Disease Relevance 0.67 Pain Relevance 0
[Effect of L-DOPA on repair of neurogenic dystrophic damage to the gastric mucosa of rats].
Regulation ([Effect) of L-DOPA associated with pain
4) Confidence 0.39 Published 1976 Journal Biull Eksp Biol Med Section Title Doc Link 1087890 Disease Relevance 0.08 Pain Relevance 0.10
Entacapone also provided benefits when given with controlled release levodopa/ AADC inhibitor or with standard levodopa/AADC inhibitor and selegiline in small trials.
Regulation (controlled) of AADC
5) Confidence 0.39 Published 1999 Journal Drugs Section Abstract Doc Link 10439935 Disease Relevance 0.73 Pain Relevance 0.11
This study examined the acute effects of a variety of NMDA and non-NMDA antagonists on the activity of aromatic l-amino acid decarboxylase (AADC) in the corpus striatum (CS) and substantia nigra (SN) of the rat.
Spec (examined) Regulation (effects) of l-amino acid decarboxylase in substantia nigra associated with substantia nigra and antagonist
6) Confidence 0.37 Published 1998 Journal Brain Res. Section Abstract Doc Link 9593857 Disease Relevance 0 Pain Relevance 0.46
Dose-dependent changes in the transcription of several genes (Camk1g, Ddc, Gpd3, c-fos and Egr1) were discovered and successfully confirmed.
Regulation (changes) of Ddc
7) Confidence 0.25 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2626604 Disease Relevance 0.19 Pain Relevance 0.03
(Camk1g) and dopa decarboxylase (Ddc) were commonly affected by both compounds indicating that for these genes there was no differences in the changes in expression elicited by equipotent doses of either pyrethroid.
Regulation (affected) of dopa decarboxylase
8) Confidence 0.25 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2626604 Disease Relevance 0 Pain Relevance 0
(Camk1g) and dopa decarboxylase (Ddc) were commonly affected by both compounds indicating that for these genes there was no differences in the changes in expression elicited by equipotent doses of either pyrethroid.
Regulation (affected) of Ddc
9) Confidence 0.25 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2626604 Disease Relevance 0 Pain Relevance 0
We further attempted to clarify whether a transmitter-like L-DOPA system is altered in these areas of adult spontaneously hypertensive rats.
Spec (whether) Regulation (altered) of L-DOPA associated with hypertension
10) Confidence 0.23 Published 1995 Journal Neuroscience Section Abstract Doc Link 7477914 Disease Relevance 0.45 Pain Relevance 0.29
Chronic IEM 1460 treatment reversed L-DOPA-induced up-regulation of pre-proenkephalin-A, and normalised pre-proenkephalin-B mRNA expression in the lateral striatum, indicating an inhibition of both behavioural and molecular correlates of priming.
Regulation (regulation) of L-DOPA in striatum
11) Confidence 0.22 Published 2010 Journal J. Neurochem. Section Abstract Doc Link 20456008 Disease Relevance 1.20 Pain Relevance 0.03
Under this experimental condition, the plasma L-DOPA level was not significantly affected by oral administration of 100 or 400 mg/kg EGCG (Figure 5A), whereas a modest decrease in plasma 3-OMD level was observed in animals treated with 400 mg/kg EGCG, but not in animals treated with 100 mg/kg EGCG (Figure 5B).
Neg (not) Regulation (affected) of L-DOPA in plasma
12) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2916818 Disease Relevance 0 Pain Relevance 0.10
Previous studies of neuropathic injury in rodents have demonstrated ddC treatment induced changes in SDF1/CXCR4 signaling by neurons [22].
Regulation (changes) of ddC in neurons associated with injury and neuropathic pain
13) Confidence 0.19 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734548 Disease Relevance 1.07 Pain Relevance 0.37
Nicotine-induced changes in the levels of three neurotransmitters, dopamine (DA), serotonin (5-HT), norepinepherine (NE), their metabolites, homovanillic acid (HVA), dihydroxyphenylacetic acid (DOPAC), 5-hydroxyindoleacetic acid (5-HIAA), and their precursor, L-DOPA, were evaluated in the ventral and dorsal hippocampus (VH and DH), prefrontal and medial temporal cortex (PFC and MTC), and the ventral tegmental area (VTA) using in vivo microdialysis in awake, freely moving, male Sprague-Dawley rats.
Regulation (changes) of L-DOPA in ventral associated with ventral tegmentum, dopamine, neurotransmitter, nicotine, hippocampus and serotonin
14) Confidence 0.18 Published 2004 Journal Neurochem. Res. Section Abstract Doc Link 15453274 Disease Relevance 0.27 Pain Relevance 0.97
Studies have shown that the use of a COMT inhibitor is particularly helpful in controlling the wearing-off phenomenon in PD patients by prolonging the circulating half-life of L-DOPA and improving its brain entry [4].
Regulation (controlling) of L-DOPA in brain associated with disease
15) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2916818 Disease Relevance 0.64 Pain Relevance 0.16
To determine the modulating effect on L-DOPA methylation in vitro, the methylation reaction was carried out in the co-presence of varying concentrations of EGCG.
Spec (determine) Regulation (effect) of L-DOPA
16) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2916818 Disease Relevance 0 Pain Relevance 0.08
L-DOPA systems for blood pressure regulation in the lower brainstem.
Regulation (regulation) of L-DOPA in brainstem associated with medulla
17) Confidence 0.15 Published 1995 Journal Neurosci. Res. Section Title Doc Link 8532212 Disease Relevance 0 Pain Relevance 0.70
We have explored probable neurotransmitter roles of L-3,4-dihydroxyphenylalanine (L-DOPA) in baroreceptor reflex and blood pressure regulation in depressor sites of the nucleus tractus solitarii (NTS) and the caudal ventrolateral medulla (CVLM), and in pressor sites of the rostral ventrolateral medulla (RVLM) in anesthetized rats.
Regulation (regulation) of L-DOPA in medulla associated with medulla, rostral ventrolateral medulla and neurotransmitter
18) Confidence 0.15 Published 1995 Journal Neurosci. Res. Section Abstract Doc Link 8532212 Disease Relevance 0 Pain Relevance 0.52
To investigate a possible effect of idazoxan on presynaptic alpha 2-adrenoceptors, we studied the effect of idazoxan on the concentrations of norepinephrine (NE) and L-DOPA in punches of locus coeruleus after dopa-decarboxylase blockade.
Regulation (effect) of L-DOPA in locus coeruleus associated with locus ceruleus
19) Confidence 0.13 Published 1994 Journal Endocrinology Section Abstract Doc Link 7988443 Disease Relevance 0.35 Pain Relevance 0.25
Peripheral administration of inhibitors of protein kinase A, protein kinase C, protein kinase G, p42/p44-mitogen-activated protein kinase (ERK1/2) and nitric oxide synthase, which have demonstrated anti-hyperalgesic effects in other models of metabolic and toxic painful peripheral neuropathies, had no effect on ddC-, ddI- and d4T-induced hypersensitivity.
Neg (no) Regulation (effect) of ddC associated with pain, hyperalgesia, kinase c, hypersensitivity and peripheral neuropathy
20) Confidence 0.13 Published 2004 Journal Pain Section Abstract Doc Link 14715401 Disease Relevance 1.47 Pain Relevance 0.49

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