INT4289

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.70
First Reported 1975
Last Reported 2010
Negated 10
Speculated 7
Reported most in Abstract
Documents 202
Total Number 209
Disease Relevance 12.30
Pain Relevance 84.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Gnrh1) extracellular region (Gnrh1) molecular_function (Gnrh1)
Anatomy Link Frequency
median eminence 26
neurons 24
pituitary 18
gonadal 16
hypothalamus 16
Gnrh1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
narcan 526 100.00 Very High Very High Very High
Dopamine 173 100.00 Very High Very High Very High
cytokine 98 100.00 Very High Very High Very High
Neurotransmitter 83 100.00 Very High Very High Very High
Serotonin 44 100.00 Very High Very High Very High
Nicotine 34 100.00 Very High Very High Very High
c fibre 4 100.00 Very High Very High Very High
Morphine 137 99.98 Very High Very High Very High
tetrodotoxin 92 99.98 Very High Very High Very High
opioid receptor 45 99.98 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 100 99.64 Very High Very High Very High
Stress 232 99.60 Very High Very High Very High
Precocious Puberty 215 99.48 Very High Very High Very High
Reprotox - General 1 25 99.10 Very High Very High Very High
Urological Neuroanatomy 45 97.68 Very High Very High Very High
Lordosis 14 97.50 Very High Very High Very High
Body Weight 35 96.80 Very High Very High Very High
Disease 31 95.56 Very High Very High Very High
Fibromyalgia 16 95.24 Very High Very High Very High
Decapitation 3 90.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Phorbol esters stimulate in vitro GnRH release from the hypothalamus of the estrogen-primed, ovariectomized rat: inhibitory effects of cocaine.
Positive_regulation (stimulate) of Localization (release) of GnRH in hypothalamus associated with cocaine
1) Confidence 0.70 Published 1992 Journal Neuroendocrinology Section Title Doc Link 1475011 Disease Relevance 0 Pain Relevance 0.20
Perfusion results showed that 10-min pulses of phorbol 12-myristate 13-acetate or phorbol 12,13-dibutyrate (PDBu) increased GnRH release in dose-dependent fashion (10(-10) to 10(-6) M) but had no effect on aminergic transmitter release.
Positive_regulation (increased) of Localization (release) of GnRH
2) Confidence 0.70 Published 1992 Journal Neuroendocrinology Section Abstract Doc Link 1475011 Disease Relevance 0 Pain Relevance 0.37
Two-way repeated measures ANOVA indicated that naloxone stimulated a significant dose-dependent increase in the release of LHRH into the media.
Positive_regulation (increase) of Localization (release) of LHRH associated with narcan
3) Confidence 0.70 Published 1998 Journal J. Gerontol. A Biol. Sci. Med. Sci. Section Abstract Doc Link 9597043 Disease Relevance 0.16 Pain Relevance 0.40
The opiate agonist DAGO (10(-6)M) did not alter the basal release of LHRH; it, however, caused a significant decrease in the K+-induced release of LHRH from hypothalami derived from intact rats and rats replaced with physiological levels of testosterone but not from those derived from castrate rats or castrate rats replaced with small amounts of testosterone.
Positive_regulation (induced) of Localization (release) of LHRH associated with agonist and opiate
4) Confidence 0.70 Published 1986 Journal Neuroendocrinology Section Abstract Doc Link 3027600 Disease Relevance 0 Pain Relevance 0.60
LHRH release was also induced by naloxone (10(-6)M), but only from tissues derived from intacts and castrates given physiological doses of testosterone.
Positive_regulation (induced) of Localization (release) of LHRH associated with narcan
5) Confidence 0.70 Published 1986 Journal Neuroendocrinology Section Abstract Doc Link 3027600 Disease Relevance 0 Pain Relevance 0.62
NAL did not significantly alter K+-induced GnRH release.
Positive_regulation (induced) of Localization (release) of GnRH associated with narcan
6) Confidence 0.70 Published 1988 Journal Endocrinology Section Abstract Doc Link 3058463 Disease Relevance 0 Pain Relevance 1.61
MOR (2 mM) stimulated basal and K+-induced GnRH release from isolated MEs, but 0.25, 5, or 100 microM MOR was without significant effect.
Positive_regulation (stimulated) of Localization (release) of GnRH in MEs associated with morphine
7) Confidence 0.70 Published 1988 Journal Endocrinology Section Abstract Doc Link 3058463 Disease Relevance 0 Pain Relevance 1.47
MOR (2 mM) stimulated basal and K+-induced GnRH release from isolated MEs, but 0.25, 5, or 100 microM MOR was without significant effect.
Positive_regulation (induced) of Localization (release) of GnRH in MEs associated with morphine
8) Confidence 0.70 Published 1988 Journal Endocrinology Section Abstract Doc Link 3058463 Disease Relevance 0 Pain Relevance 1.46
Adrenergic mediation of the naloxone-induced GnRH release from hypothalami of ovariectomized, steroid-treated immature rats.
Positive_regulation (induced) of Localization (release) of GnRH associated with narcan
9) Confidence 0.70 Published 1991 Journal Acta Endocrinol. Section Title Doc Link 1665001 Disease Relevance 0.09 Pain Relevance 0.47
Gonadal steroids exert positive feedback actions which also result in an increase in the amplitude of LHRH release, and this action may be exerted through a combination of cellular mechanisms which culminate in the production of a unique, punctuated set of synaptic signals.
Positive_regulation (increase) of Localization (release) of LHRH in Gonadal
10) Confidence 0.70 Published 1991 Journal Recent Prog. Horm. Res. Section Abstract Doc Link 1745827 Disease Relevance 0 Pain Relevance 0.09
Copper, complexed to histidine (CuHis), stimulates LHRH release from explants of the median eminence area (MEA).
Positive_regulation (stimulates) of Localization (release) of LHRH in median eminence
11) Confidence 0.69 Published 1986 Journal Neuroendocrinology Section Abstract Doc Link 3027598 Disease Relevance 0 Pain Relevance 0
It is suggested that the facilitatory effect of naloxone on masculine sexual performance results, in part, from a drug-induced release of LHRH.
Positive_regulation (induced) of Localization (release) of LHRH associated with narcan
12) Confidence 0.69 Published 1980 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 6994127 Disease Relevance 0 Pain Relevance 0.26
In vitro, the potassium-induced release of GnRH from perifused medial hypothalami was reduced by 60% in 4-APP-treated male rats while hypothalamic GnRH content remained unchanged.
Positive_regulation (induced) of Localization (release) of GnRH in medial
13) Confidence 0.69 Published 1985 Journal Endocrinology Section Abstract Doc Link 3886368 Disease Relevance 0.07 Pain Relevance 0.31
The mean interpulse interval of pulsatile GnRH release into the medium was 34.2+/-2.0 min in the control period and increased to 95.3+/-19.0 min (n=6) in the period of nicotine treatment at a concentration of 500 nM, showing an inhibitory effect of nicotine on pulsatile GnRH release.
Positive_regulation (increased) of Localization (release) of GnRH associated with nicotine
14) Confidence 0.69 Published 2004 Journal Psychoneuroendocrinology Section Abstract Doc Link 15110924 Disease Relevance 0 Pain Relevance 0.63
The NAL pulse stimulated LHRH release from the MBH-POA of intact and castrated rats (P less than 0.05); the amount released by the MBH-POA of intact rats was significantly higher than that from castrated rats (P less than 0.05).
Positive_regulation (stimulated) of Localization (release) of LHRH associated with narcan
15) Confidence 0.69 Published 1987 Journal Endocrinology Section Abstract Doc Link 3536452 Disease Relevance 0 Pain Relevance 0.50
Disinhibition of LHRH neurons would result in the increased release of LHRH into the hypophysial portal vessels.
Positive_regulation (result) of Localization (release) of LHRH in neurons
16) Confidence 0.69 Published 1988 Journal Neuroendocrinology Section Abstract Doc Link 3399035 Disease Relevance 0 Pain Relevance 0.34
The amplitude of the K+-induced LHRH release was slightly increased in the presence of progesterone (10(-7) M) but only from MBH slices of OVX-E2-treated rats.
Positive_regulation (induced) of Localization (release) of LHRH
17) Confidence 0.69 Published 1985 Journal Neuroendocrinology Section Abstract Doc Link 2581165 Disease Relevance 0 Pain Relevance 0.14
The amplitude of the K+-induced LHRH release was slightly increased in the presence of progesterone (10(-7) M) but only from MBH slices of OVX-E2-treated rats.
Positive_regulation (increased) of Localization (release) of LHRH
18) Confidence 0.69 Published 1985 Journal Neuroendocrinology Section Abstract Doc Link 2581165 Disease Relevance 0 Pain Relevance 0.14
Lastly, all the effects of GABA upon GnRH release appear to be mediated through GABAA receptors.
Positive_regulation (mediated) of Localization (release) of GnRH associated with gaba
19) Confidence 0.69 Published 1988 Journal Brain Res. Bull. Section Abstract Doc Link 3061570 Disease Relevance 0 Pain Relevance 0.97
When lymphocyte lysates were applied to rat anterior pituitary cells in monolayer culture, significant stimulation of LHRH secretion was seen, from 2,144 +/- 54 pg LH/ml.4 h to 15,364 +/- 587 pg LH/ml.4 h (P less than 0.001), a finding verified in five additional experiments.
Positive_regulation (stimulation) of Localization (secretion) of LHRH in anterior pituitary
20) Confidence 0.69 Published 1990 Journal Endocrinology Section Abstract Doc Link 2184019 Disease Relevance 0 Pain Relevance 0.14

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox