INT42941

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Context Info
Confidence 0.57
First Reported 1982
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.33
Pain Relevance 1.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transferase activity, transferring glycosyl groups (Dpagt1) endoplasmic reticulum (Dpagt1)
Anatomy Link Frequency
liver 2
Dpagt1 (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate 1 100.00 Very High Very High Very High
Paracetamol 13 99.16 Very High Very High Very High
Pain 1 71.80 Quite High
Parenteral administration 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Injury 4 98.84 Very High Very High Very High
Toxicity 4 97.80 Very High Very High Very High
Lysosome Storage Disease 2 97.76 Very High Very High Very High
Hepatotoxicity 4 96.24 Very High Very High Very High
Paralysis 1 88.32 High High
Disease 1 82.88 Quite High
Arthralgia 1 72.04 Quite High
Stress 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
P. niruri significantly reduced the elevated glutamate pyruvate transaminase (GPT) and alkaline phosphatase (ALP) levels in the sera of toxicity induced mice, compared with the control group.
Negative_regulation (reduced) of GPT associated with toxicity and glutamate
1) Confidence 0.57 Published 2006 Journal Phytother Res Section Abstract Doc Link 16718736 Disease Relevance 0.37 Pain Relevance 0.43
Diethyldithiocarbamate (DTC) and carbon disulfide (CS2), at nearly equimolar oral dose levels, protected mice against liver damage induced by carbon tetrachloride, chloroform, bromotrichloromethane, thioacetamide, bromobenzene, furosemide, acetaminophen, dimethylnitrosamine and trichloroethylene, as evidenced by the suppression of elevations in plasma GPT activity and liver calcium content, and of histopathological alterations.
Negative_regulation (suppression) of GPT in liver associated with paracetamol and hepatotoxicity
2) Confidence 0.26 Published 1982 Journal Biochem. Pharmacol. Section Abstract Doc Link 6291543 Disease Relevance 0.26 Pain Relevance 0.10
The liver injury produced by Par was remarkably decreased as indicated by decrease of sGPT and by histopathological examination.
Negative_regulation (decrease) of sGPT in liver associated with paracetamol and injury
3) Confidence 0.04 Published 1995 Journal Yao Xue Xue Bao Section Abstract Doc Link 7660799 Disease Relevance 0.36 Pain Relevance 0.64
Loss of N-acetylglucosamine-1-phosphotransferase gamma subunit due to intronic mutation in GNPTG causes mucolipidosis type III gamma: Implications for molecular and cellular diagnostics.
Negative_regulation (Loss) of N-acetylglucosamine-1-phosphotransferase associated with lysosome storage disease
4) Confidence 0.01 Published 2010 Journal Am. J. Med. Genet. A Section Title Doc Link 20034096 Disease Relevance 0.35 Pain Relevance 0.07

General Comments

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