INT42943

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Context Info
Confidence 0.18
First Reported 1980
Last Reported 2011
Negated 0
Speculated 1
Reported most in Abstract
Documents 9
Total Number 10
Disease Relevance 2.68
Pain Relevance 3.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Atrn) extracellular space (Atrn) extracellular region (Atrn)
plasma membrane (Atrn) molecular_function (Atrn) cytoplasm (Atrn)
Anatomy Link Frequency
adipocyte 2
brain 1
small intestine 1
Atrn (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ASIC 2 100.00 Very High Very High Very High
aspirin 16 99.98 Very High Very High Very High
Neuropathic pain 8 99.82 Very High Very High Very High
local anesthetic 8 99.82 Very High Very High Very High
Glutamate 2 99.50 Very High Very High Very High
alcohol 16 99.48 Very High Very High Very High
sodium channel 2 99.24 Very High Very High Very High
ischemia 17 99.10 Very High Very High Very High
Neurotransmitter 3 99.00 Very High Very High Very High
Glutamate receptor 4 97.04 Very High Very High Very High
Disease Link Frequency Relevance Heat
Neuropathic Pain 9 99.82 Very High Very High Very High
Cv Unclassified Under Development 15 99.10 Very High Very High Very High
Obesity 9 97.40 Very High Very High Very High
Toxicity 18 97.24 Very High Very High Very High
Nervous System Injury 9 97.04 Very High Very High Very High
Death 5 95.96 Very High Very High Very High
Convulsion 5 94.64 High High
Increased Venous Pressure Under Development 2 87.36 High High
Stress 1 81.24 Quite High
Body Weight 2 80.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus the local anesthetic-induced increase in membrane fluidity could not improve the age-dependent impairment of thymidine transport.
Positive_regulation (increase) of membrane associated with local anesthetic
1) Confidence 0.18 Published 1980 Journal Mech. Ageing Dev. Section Abstract Doc Link 7206808 Disease Relevance 0 Pain Relevance 0.49
Benzyl alcohol and ethanol dramatically increased the fluidity of the adipocyte ghost membrane, as indicated by decreases in the polarity-corrected order parameter S.
Positive_regulation (increased) of membrane in adipocyte associated with alcohol
2) Confidence 0.04 Published 1982 Journal Biochim. Biophys. Acta Section Abstract Doc Link 6291605 Disease Relevance 0.22 Pain Relevance 0.31
Temperature-induced increases in membrane fluidity, detected with I(12,3), that closely paralleled the fluidity effects of alcohols were associated only with increases in basal and insulin-stimulated glucose uptake.
Positive_regulation (increases) of membrane
3) Confidence 0.04 Published 1982 Journal Biochim. Biophys. Acta Section Abstract Doc Link 6291605 Disease Relevance 0.21 Pain Relevance 0.25
Alcohols inhibit adipocyte basal and insulin-stimulated glucose uptake and increase the membrane lipid fluidity.
Positive_regulation (increase) of membrane in adipocyte
4) Confidence 0.04 Published 1982 Journal Biochim. Biophys. Acta Section Title Doc Link 6291605 Disease Relevance 0.18 Pain Relevance 0.31
Physical correlation of the membrane oxidative damage was evident as the Fourier Transformation Infra Red (FTIR) study of the Aspirin treated membrane, which include an increased proportion of gauche to trans conformer, shift in the methylene C-H asymmetric and symmetric stretching frequencies, C = O double bond stretching, NH bending, antisymmetric (N)-CH3 bending, C-N stretching and antisymmetric CNC stretching while there was no change in the CH2 wagging and twisting as well as in NH-bending amide bond I and II.
Positive_regulation (treated) of membrane associated with aspirin
5) Confidence 0.02 Published 2010 Journal Nutr Hosp Section Abstract Doc Link 20449540 Disease Relevance 0.08 Pain Relevance 0.28
Since the synaptic release of glutamate mainly depends upon the activation of membrane voltage-sensitive sodium channels (VSSCs), the nature of interactions between nefopam and these ionic channels was studied by evaluating the effects of nefopam on binding of 3H-batrachotoxinin, a specific ligand of the VSSCs in rat brain membrane preparations.
Positive_regulation (activation) of membrane in brain associated with glutamate and sodium channel
6) Confidence 0.01 Published 2004 Journal Brain Res. Section Abstract Doc Link 15193535 Disease Relevance 0.16 Pain Relevance 0.38
Aspirin and nimesulide exhibited an increase in the brush border membrane (BBM) bound enzyme activities like sucrase, lactase, maltase and alkaline phosphatase in the small intestine while celecoxib showed decrease in lactase, maltase and alkaline phosphatase.
Positive_regulation (increase) of membrane in small intestine associated with aspirin
7) Confidence 0.01 Published 2006 Journal Nutr Hosp Section Abstract Doc Link 17147060 Disease Relevance 0.07 Pain Relevance 0.28
The loss of KATP current contributes to neuropathic pain through increased membrane excitability, amplified neurotransmitter release [9], and possibly increased susceptibility to cell death.
Spec (possibly) Positive_regulation (increased) of membrane associated with neurotransmitter, neuropathic pain and death
8) Confidence 0.01 Published 2010 Journal Mol Pain Section Body Doc Link PMC2825500 Disease Relevance 0.80 Pain Relevance 0.46
Both excitatory and secretory responses to ischemia are thought to be mediated primarily by the activation of acid sensing channels in the cell membrane that causes membrane depolarization and calcium entry (Benson et al. 1999; Bevan and Geppetti 1994; Bevan and Yeats 1991; Caterina et al. 1997; Davies et al. 1988; Immke and McCleskey 2001a,b; Konnerth et al. 1987; Krishtal and Pidoplichko 1980, 1981; Longhurst et al. 2001; Liu et al. 2004; Pan et al. 1999; Waldmann and Lazdunski 1998).
Positive_regulation (activation) of membrane associated with ischemia and asic
9) Confidence 0.00 Published 2008 Journal Journal of Neurophysiology Section Body Doc Link PMC2493471 Disease Relevance 0.78 Pain Relevance 0.66
The subsequent increase of membrane fluidity was supposed to be one of the key steps in saponin-induced toxicity [61].
Positive_regulation (increase) of membrane associated with toxicity
10) Confidence 0.00 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2952298 Disease Relevance 0.16 Pain Relevance 0

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