INT42958

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Context Info
Confidence 0.10
First Reported 1982
Last Reported 1982
Negated 1
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
brain 2
Slc6a2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
monoamine 3 96.12 Very High Very High Very High
antidepressant 5 95.78 Very High Very High Very High
agonist 1 76.32 Quite High
Clonidine 2 75.68 Quite High
adenocard 2 75.00 Quite High
medulla 1 66.80 Quite High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Various antidepressant drugs (monoamine oxidase inhibitors and tricyclics) enhance norepinephrine availability and lead to adaptive changes in brain noradrenergic systems, namely, decreases in the number of beta receptors and in the responsiveness of adenylate cyclase to norepinephrine monamine oxidase inhibitor, but not after 3 days, there is an increase in norepinephrine release from rat brain microsacs in response to 43 mM KCl stimulation.
Neg (not) Positive_regulation (responsiveness) of Negative_regulation (inhibitor) of norepinephrine monamine oxidase in brain associated with antidepressant and monoamine
1) Confidence 0.10 Published 1982 Journal J. Neurosci. Section Abstract Doc Link 6292376 Disease Relevance 0 Pain Relevance 0.42

General Comments

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