INT42959

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Context Info
Confidence 0.06
First Reported 1982
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.56
Pain Relevance 1.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Vom2r2) signal transducer activity (Vom2r2)
Anatomy Link Frequency
sensory neurons 1
brainstem 1
mesangial cells 1
Vom2r2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 4 100.00 Very High Very High Very High
medulla 1 100.00 Very High Very High Very High
Clonidine 2 98.88 Very High Very High Very High
qutenza 7 98.16 Very High Very High Very High
agonist 1 96.04 Very High Very High Very High
Sciatic nerve 3 86.80 High High
Inflammation 2 83.80 Quite High
adenocard 2 82.08 Quite High
cINOD 1 79.28 Quite High
antidepressant 5 75.00 Quite High
Disease Link Frequency Relevance Heat
Nephritis 1 96.60 Very High Very High Very High
Renal Disease 3 94.68 High High
INFLAMMATION 3 83.80 Quite High
Injury 1 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These functional changes in norepinephrine release mechanisms are accompanied by a 53% reduction in brainstem alpha 2 receptor density as measured by [3H]clonidine binding.
Negative_regulation (reduction) of 2 receptor in brainstem associated with medulla and clonidine
1) Confidence 0.06 Published 1982 Journal J. Neurosci. Section Abstract Doc Link 6292376 Disease Relevance 0 Pain Relevance 0.54
In this study we assessed the effect of a TxA2 synthase inhibitor, Dazmegrel, and a TxA2 receptor antagonist, SQ-29 548, on glomerular PGE2, LTB4, and 12-HETE synthesis in a model of mesangial nephritis induced in the rat by the administration of a monoclonal antibody against the Thy 1.1 antigen of rat mesangial cells.
Negative_regulation (antagonist) of TxA2 receptor in mesangial cells associated with nephritis and antagonist
2) Confidence 0.03 Published 1999 Journal J. Lab. Clin. Med. Section Abstract Doc Link 10560941 Disease Relevance 0.56 Pain Relevance 0.22
Capsaicin- and mustard oil-induced extracellular signal-regulated protein kinase phosphorylation in sensory neurons in vivo: effects of neurokinins 1 and 2 receptor antagonists and of a nitric oxide synthase inhibitor.
Negative_regulation (inhibitor) of and 2 receptor in sensory neurons associated with qutenza and antagonist
3) Confidence 0.03 Published 2009 Journal Basic Clin. Pharmacol. Toxicol. Section Title Doc Link 19152548 Disease Relevance 0 Pain Relevance 0.67

General Comments

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