INT4297

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Context Info
Confidence 0.42
First Reported 1975
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 21
Total Number 23
Disease Relevance 12.70
Pain Relevance 10.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CFP) extracellular region (CFP)
Anatomy Link Frequency
PFC 3
amygdala 2
proximal 2
insular cortex 1
anterior 1
CFP (Homo sapiens)
Pain Link Frequency Relevance Heat
amygdala 154 100.00 Very High Very High Very High
insula 145 100.00 Very High Very High Very High
Hippocampus 47 100.00 Very High Very High Very High
lidocaine 30 99.74 Very High Very High Very High
Dopamine 344 99.66 Very High Very High Very High
Thalamus 55 99.56 Very High Very High Very High
backache 22 99.56 Very High Very High Very High
Nucleus accumbens 90 99.52 Very High Very High Very High
Anterior cingulate cortex 59 99.36 Very High Very High Very High
Ventral tegmentum 53 99.26 Very High Very High Very High
Disease Link Frequency Relevance Heat
Poisoning 130 100.00 Very High Very High Very High
Depression 399 99.84 Very High Very High Very High
Conduct Disorder 32 99.66 Very High Very High Very High
Low Back Pain 85 99.56 Very High Very High Very High
Disease 37 99.32 Very High Very High Very High
Pain 443 98.82 Very High Very High Very High
Manic Depressive Disorder 28 98.40 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 203 98.20 Very High Very High Very High
Renal Disease 2 98.04 Very High Very High Very High
Post-traumatic Stress Disorder 61 97.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Serum properdin levels were significantly reduced and immunofluorescence studies demonstrated properdin deposition within the glomeruli, C1, C4 and C2 were not depressed nor were they demonstrable within the glomeruli.
Negative_regulation (reduced) of properdin
1) Confidence 0.42 Published 1975 Journal Clin. Nephrol. Section Abstract Doc Link 1097145 Disease Relevance 0.53 Pain Relevance 0.14
Deficiencies of terminal complement component, properdin, factor D, and mannan-binding lectin (MBL) have been associated with increased susceptibility to meningo-coccal infection (Pollard and Frasch 2001).
Negative_regulation (Deficiencies) of properdin associated with infection
2) Confidence 0.42 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621387 Disease Relevance 0.89 Pain Relevance 0.04
Furthermore, blockade of VTA activity with lidocaine transiently eliminated PFC LFPs, but not PFC cell up states; instead, up states became irregular during intra-VTA lidocaine administration.
Negative_regulation (eliminated) of PFC in PFC associated with ventral tegmentum and lidocaine
3) Confidence 0.41 Published 2004 Journal Synapse Section Abstract Doc Link 15034920 Disease Relevance 0.06 Pain Relevance 0.96
Outcome variance (irrespective of the potential for loss) is highlighted in economic models of risk (Lopes, 1987) and may also be represented in vmPFC and insular cortex circuitry (Sanfey et al., 2003; Preuschoff et al., 2006).
Negative_regulation (represented) of vmPFC in insular cortex
4) Confidence 0.36 Published 2008 Journal Brain Section Body Doc Link PMC2367692 Disease Relevance 0.25 Pain Relevance 0.07
It is not known whether the effect of insular damage is analogous to the effect of vmPFC damage, or whether these regions contribute differentially to choice behaviour.
Spec (whether) Negative_regulation (effect) of vmPFC
5) Confidence 0.36 Published 2008 Journal Brain Section Abstract Doc Link PMC2367692 Disease Relevance 0.06 Pain Relevance 0
Primary prevention of CFP relies heavily on providing education about CFP and the fish associated with it to consumers, especially those most susceptible to CFP, such as recreational and subsistence fishermen and the communities that they serve.
Negative_regulation (prevention) of CFP associated with poisoning
6) Confidence 0.35 Published 2008 Journal Marine Drugs Section Body Doc Link PMC2579736 Disease Relevance 0.65 Pain Relevance 0
Postmortem and MRI studies have found glial loss and volume reductions in the PFC in major depressive disorder (MDD) and bipolar disorder (BPD) [209-214] as well as extensive losses in Cg25 and proximal paralimbic regions [163,201,215-221].
Negative_regulation (reductions) of PFC in proximal associated with manic depressive disorder, depression and bronchopulmonary dysplasia
7) Confidence 0.27 Published 2008 Journal Ann Gen Psychiatry Section Body Doc Link PMC2515304 Disease Relevance 0.68 Pain Relevance 0.32
Postmortem and MRI studies have found glial loss and volume reductions in the PFC in major depressive disorder (MDD) and bipolar disorder (BPD) [209-214] as well as extensive losses in Cg25 and proximal paralimbic regions [163,201,215-221].
Negative_regulation (loss) of PFC in proximal associated with manic depressive disorder, depression and bronchopulmonary dysplasia
8) Confidence 0.27 Published 2008 Journal Ann Gen Psychiatry Section Body Doc Link PMC2515304 Disease Relevance 0.68 Pain Relevance 0.35
Using autobiographical scripts designed to evoke strong emotion, healthy control subjects showed increased blood flow in the vmPFC during script-induced anger compared to patients with anger attacks who showed an impoverished vmPFC response [131].
Negative_regulation (impoverished) of vmPFC in blood
9) Confidence 0.27 Published 2008 Journal Ann Gen Psychiatry Section Body Doc Link PMC2515304 Disease Relevance 0.46 Pain Relevance 0.06
Chronic tension-type headache patients showed an overall decrease in their gray matter volume in the pain matrix [37], while chronic back pain patients also showed reduced gray matter density in the bilateral dorsolateral PFC and right thalamus compared to healthy controls [38].
Negative_regulation (reduced) of PFC in thalamus associated with low back pain, pain matrix, thalamus, headache and backache
10) Confidence 0.21 Published 2010 Journal The Korean Journal of Pain Section Body Doc Link PMC2935976 Disease Relevance 1.30 Pain Relevance 1.46
Burgmer et al. [41] also reported decreased gray matter volume in the PFC, amygdala, and ACC.
Negative_regulation (decreased) of PFC in amygdala associated with anterior cingulate cortex and amygdala
11) Confidence 0.21 Published 2010 Journal The Korean Journal of Pain Section Body Doc Link PMC2935976 Disease Relevance 0.95 Pain Relevance 1.32
Gray matter reduction in the right insula, right ventromedial PFC, and right nucleus accumbens was particularly more severe compared to that in other regions [39].
Negative_regulation (reduction) of PFC in nucleus accumbens associated with nucleus accumbens and insula
12) Confidence 0.21 Published 2010 Journal The Korean Journal of Pain Section Body Doc Link PMC2935976 Disease Relevance 1.13 Pain Relevance 1.27
Thus reduction in PFC cell activity leads to an excess of DA receptor activation at subcortical nuclei.
Negative_regulation (reduction) of PFC associated with dopamine
13) Confidence 0.16 Published 2008 Journal Behav Brain Funct Section Body Doc Link PMC2289834 Disease Relevance 0 Pain Relevance 0.71
Thus, impairment of the PFC is directly linked to this key symptom of depression [87].
Negative_regulation (impairment) of PFC associated with depression
14) Confidence 0.15 Published 2010 Journal Behav Brain Funct Section Body Doc Link PMC3009949 Disease Relevance 0.93 Pain Relevance 0.57
The most prevalent functional neuroimaging finding is that of a relatively diminished responsivity in medial PFC (decreased activation and/or failure to activate) in PTSD [13], which would be consistent with the present results showing PFC dysfunction as indicated by enhanced abnormal slow waves in right frontal areas.
Negative_regulation (diminished) of PFC in medial associated with post-traumatic stress disorder
15) Confidence 0.12 Published 2007 Journal BMC Psychiatry Section Body Doc Link PMC2176059 Disease Relevance 0.82 Pain Relevance 0.25
On the other hand, supra-normal DA stimulation may impair PFC function, providing an inverted-U effect.
Spec (may) Negative_regulation (impair) of PFC in PFC associated with dopamine
16) Confidence 0.12 Published 2008 Journal Behav Brain Funct Section Body Doc Link PMC2289834 Disease Relevance 0.15 Pain Relevance 0.23
They suggest that the majority of alpha-2 receptors are localised postsynaptically to NE terminals, and that blockade of alpha-2 receptors in the PFC of monkeys erodes delay-related cell-firing and recreates all the symptoms of ADHD, with poor impulse control, impaired working memory with underlying distractibility.
Negative_regulation (blockade) of PFC associated with attention deficit hyperactivity disorder
17) Confidence 0.12 Published 2008 Journal Behav Brain Funct Section Body Doc Link PMC2289834 Disease Relevance 0.28 Pain Relevance 0.22
The present developmental hypothesis suggests early deficits in PFC connectivity, in both young children and in ADHD.
Negative_regulation (deficits) of PFC associated with attention deficit hyperactivity disorder
18) Confidence 0.12 Published 2008 Journal Behav Brain Funct Section Body Doc Link PMC2289834 Disease Relevance 0.50 Pain Relevance 0.18
The authors demonstrated that the more anterior sectors of the PFC were distinctively recruited when altruistic choices prevail over selfish material interests.
Negative_regulation (recruited) of PFC in anterior
19) Confidence 0.08 Published 2008 Journal Philosophical Transactions of the Royal Society B: Biological Sciences Section Body Doc Link PMC2581786 Disease Relevance 0.06 Pain Relevance 0
Several studies have shown that direct appraisals of the self as compared to others more strongly recruited mPFC and right rostrolateral prefrontal cortex.
Negative_regulation (recruited) of mPFC in cortex
20) Confidence 0.04 Published 2010 Journal Brain Struct Funct Section Body Doc Link PMC2886901 Disease Relevance 0 Pain Relevance 0.08

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