INT42979

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Context Info
Confidence 0.32
First Reported 1982
Last Reported 2009
Negated 1
Speculated 0
Reported most in Abstract
Documents 47
Total Number 49
Disease Relevance 12.24
Pain Relevance 14.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
caudate nucleus 1
Hepatocyte 1
erythrocytes 1
spinal cord 1
globus pallidus 1
INSRR (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 189 100.00 Very High Very High Very High
GABA receptor 4 100.00 Very High Very High Very High
dopamine receptor 1 100.00 Very High Very High Very High
Immobilon 3 99.98 Very High Very High Very High
adenocard 30 99.94 Very High Very High Very High
Cannabinoid 14 99.86 Very High Very High Very High
gABA 46 99.84 Very High Very High Very High
Kinase C 855 99.80 Very High Very High Very High
Antinociceptive 5 99.80 Very High Very High Very High
Spinal cord 2 99.72 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 795 99.80 Very High Very High Very High
Dysmenorrhea 5 99.58 Very High Very High Very High
Disease 135 99.02 Very High Very High Very High
Pancreatic Cancer 213 98.80 Very High Very High Very High
Pain 23 98.64 Very High Very High Very High
Nociception 9 98.16 Very High Very High Very High
Prostate Cancer 41 97.70 Very High Very High Very High
INFLAMMATION 85 97.64 Very High Very High Very High
Injury 15 97.36 Very High Very High Very High
Neuropathic Pain 2 96.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
First, the very early stages of the disease (grade 0) were characterized by a major loss of cannabinoid CB(1), dopamine D(2) and adenosine A(2a) receptor binding in the caudate nucleus, putamen and globus pallidus externus and an increase in GABA(A) receptor binding in the globus pallidus externus.
Positive_regulation (increase) of ) receptor in caudate nucleus associated with gaba, adenocard, dopamine, cannabinoid and disease
1) Confidence 0.32 Published 2000 Journal Neuroscience Section Abstract Doc Link 10828533 Disease Relevance 0.57 Pain Relevance 0.57
In summary, the present results demonstrate that invading endometrial glands in adenomyosis selectively express more hCG/LH receptor mRNA and immunoreactive receptor protein than noninvading glands.
Positive_regulation (more) of receptor in glands associated with dismenorea
2) Confidence 0.17 Published 1993 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 7680356 Disease Relevance 0.60 Pain Relevance 0.41
First, the very early stages of the disease (grade 0) were characterized by a major loss of cannabinoid CB(1), dopamine D(2) and adenosine A(2a) receptor binding in the caudate nucleus, putamen and globus pallidus externus and an increase in GABA(A) receptor binding in the globus pallidus externus.
Positive_regulation (increase) of ) receptor in putamen associated with gaba, adenocard, dopamine, cannabinoid and disease
3) Confidence 0.11 Published 2000 Journal Neuroscience Section Abstract Doc Link 10828533 Disease Relevance 0.57 Pain Relevance 0.57
First, the very early stages of the disease (grade 0) were characterized by a major loss of cannabinoid CB(1), dopamine D(2) and adenosine A(2a) receptor binding in the caudate nucleus, putamen and globus pallidus externus and an increase in GABA(A) receptor binding in the globus pallidus externus.
Positive_regulation (increase) of ) receptor in globus pallidus associated with gaba, adenocard, dopamine, cannabinoid and disease
4) Confidence 0.11 Published 2000 Journal Neuroscience Section Abstract Doc Link 10828533 Disease Relevance 0.57 Pain Relevance 0.57
Recombinant human 5-HT1D alpha and 5-HT1D beta receptor subtypes were stably expressed in NIH-3T3 fibroblasts (1D alpha cell line) and Y-1 adrenocortical tumor cells (1D beta cell line), respectively, for pharmacological evaluations of serotonergic compounds to inhibit forskolin-stimulated cAMP accumulation (FSCA). [3H]LSD saturation studies indicated that 5-HT1D receptor expression levels were slightly higher in the 1D beta cell line (Bmax = 1334 +/- 134 fmol/mg protein) than in the 1D alpha cell line (Bmax = 900 +/- 218 fmol/mg protein). 5-HT inhibited FSCA with similar potencies (EC50 approximately 2 nM) in both assay systems.
Positive_regulation (higher) of receptor in beta cell associated with cancer
5) Confidence 0.08 Published 1996 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 8878051 Disease Relevance 0.10 Pain Relevance 0.10
These data suggest that the development of tolerance to opioids in human placenta starts with an apparent down regulation and change in the affinity of the receptors and may involve downstream events that transduce receptor activation into a biological response.
Positive_regulation (activation) of transduce receptor in placenta associated with tolerance and opioid
6) Confidence 0.07 Published 1995 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7791132 Disease Relevance 0 Pain Relevance 0.78
The current study assessed whether dopamine receptor agonists could further enhance the antinociceptive activity of duloxetine in an animal model of injury-induced central sensitization, the rat formalin test.
Positive_regulation (enhance) of receptor associated with central sensitization, dopamine receptor, injury, agonist, duloxetine and antinociceptive
7) Confidence 0.05 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17725928 Disease Relevance 0.51 Pain Relevance 1.12
In the spinal cord, adenosine A receptor activation produces antinociceptive properties in acute nociceptive, inflammatory and neuropathic pain tests.
Positive_regulation (activation) of receptor in spinal cord associated with nociception, adenocard, inflammation, neuropathic pain, antinociceptive and spinal cord
8) Confidence 0.04 Published 1998 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9650842 Disease Relevance 0.86 Pain Relevance 1.47
A consistent finding is that androgen receptor (AR) gene mutations, present in metastatic prostate cancer and in human prostate cancer cell lines as well as in xenograft and other animal models, result in decreased specificity of ligand-binding and inappropriate receptor activation by estrogens, progestins, adrenal androgens, glucocorticoids and/or AR antagonists.
Positive_regulation (activation) of inappropriate receptor associated with antagonist and prostate cancer
9) Confidence 0.02 Published 2001 Journal Clin. Cancer Res. Section Abstract Doc Link 11350894 Disease Relevance 0.50 Pain Relevance 0.13
Therefore a therapeutic strategy for these diseases may be supplementary treatment with drugs which increase GABA receptor activity.
Positive_regulation (increase) of receptor associated with gaba receptor and disease
10) Confidence 0.02 Published 1982 Journal Pharm Weekbl Sci Section Abstract Doc Link 6292818 Disease Relevance 0.91 Pain Relevance 0.83
The present studies were designed to determine the specific contribution of MC4R exoloops and transmembrane domains to AGRP binding by using chimeric receptor constructs of the human melanocortin-1 receptor (hMC1R), a receptor that is not inhibited by AGRP, and the human MC4R (hMC4R), a receptor that is potently inhibited by AGRP.
Positive_regulation (using) of receptor associated with melanocortin 1 receptor
11) Confidence 0.01 Published 2003 Journal Mol. Pharmacol. Section Abstract Doc Link 12815165 Disease Relevance 0 Pain Relevance 0.14
Our findings indicate that the mu opioid receptor is present on human erythrocytes, although with considerable variation in receptor levels, and that the levels of this receptor are significantly elevated with chronic opioid exposure.
Positive_regulation (elevated) of receptor in erythrocytes associated with mu opioid receptor and opioid
12) Confidence 0.01 Published 2002 Journal Addict Biol Section Abstract Doc Link 12006216 Disease Relevance 0 Pain Relevance 0.98
A disproportionate change in agonist potency versus affinity observed with simultaneous mutation of these acidic residues (mutant constructs D117A/D121A or E94A/D117A/D121A) or introduction of a single positive charge (mutant construct D121K) also implicates these residues in receptor activation.
Positive_regulation (activation) of receptor associated with agonist and potency
13) Confidence 0.01 Published 1997 Journal J. Biol. Chem. Section Abstract Doc Link 9287296 Disease Relevance 0 Pain Relevance 0.50
Activation of receptor function of platelet membrane glycoprotein (GP) IIb-IIIa leads to the binding of fibrinogen and is the final common pathway to platelet aggregation.
Positive_regulation (Activation) of receptor in platelet
14) Confidence 0.01 Published 1997 Journal Am. J. Cardiol. Section Abstract Doc Link 9291241 Disease Relevance 0.22 Pain Relevance 0
Decrease in the mRNA levels of these genes, observed during the biphasic effect is due to the Receptor Ck dependent DAGK activation resulting in the inhibition of PKC (Figures 5 &11).
Positive_regulation (activation) of Receptor associated with kinase c
15) Confidence 0.01 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.05 Pain Relevance 0.31
Despite the ability of activated Receptor Ck to generate the second messenger PA as reported by previous studies, the experiments of this study demonstrate that Receptor Ck is not able to activate PKC.
Positive_regulation (activated) of Receptor associated with kinase c
16) Confidence 0.01 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0 Pain Relevance 0.28
The reduction of the receptor level with 1 microM betaFNA significantly increased the rate of etorphine-induced receptor desensitization.
Positive_regulation (induced) of receptor associated with immobilon
17) Confidence 0.01 Published 2000 Journal Mol. Pharmacol. Section Abstract Doc Link 10908307 Disease Relevance 0.07 Pain Relevance 0.42
Previously, we reported that the time course for the rapid phosphorylation rate of mu-opioid receptor expressed in human embryonic kidney (HEK)293 cells did not correlate with the slow receptor desensitization rate induced by [D-Ala(2),N-MePhe(4), Gly-ol(5)]-enkephalin (DAMGO).
Positive_regulation (induced) of receptor in embryonic kidney associated with enkephalin and opioid receptor
18) Confidence 0.01 Published 2000 Journal Mol. Pharmacol. Section Abstract Doc Link 10908307 Disease Relevance 0 Pain Relevance 0.27
In order to determine whether cholesterol-activated Receptor Ck regulates the transcription of hTERT, c-myc and PPAR?
Positive_regulation (activated) of Receptor
19) Confidence 0.01 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.23 Pain Relevance 0
Due to the increase in the generation of PA when 25OH-C is present along with activated Receptor Ck, PKC could be activated (even in the presence of activated Receptor Ck) (Figure 11), leading to the observed transient upregulation of the mRNA expression of c-myc, PPAR?
Positive_regulation (activated) of Receptor associated with kinase c
20) Confidence 0.01 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0 Pain Relevance 0.30

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