INT4298

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.50
First Reported 1975
Last Reported 2008
Negated 1
Speculated 1
Reported most in Abstract
Documents 30
Total Number 31
Disease Relevance 1.79
Pain Relevance 13.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gh1) signal transduction (Gh1) mitochondrion (Gh1)
extracellular space (Gh1) extracellular region (Gh1) plasma membrane (Gh1)
Anatomy Link Frequency
plasma 25
somatotrophs 2
sympathetic 2
pituitary 2
median eminence 2
Gh1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Clonidine 84 100.00 Very High Very High Very High
Enkephalin 5 99.96 Very High Very High Very High
Somatostatin 62 99.84 Very High Very High Very High
ketamine 1 99.84 Very High Very High Very High
Morphine 18 99.58 Very High Very High Very High
Opioid 6 99.50 Very High Very High Very High
agonist 34 99.40 Very High Very High Very High
opioid receptor 5 99.24 Very High Very High Very High
anesthesia 4 99.14 Very High Very High Very High
Intracerebroventricular 6 98.64 Very High Very High Very High
Disease Link Frequency Relevance Heat
Body Weight 8 99.84 Very High Very High Very High
Eating Disorder 4 99.64 Very High Very High Very High
Diabetes Mellitus 9 99.08 Very High Very High Very High
Pressure Volume 2 Under Development 2 92.32 High High
Hypotension 5 91.40 High High
Decapitation 1 88.60 High High
Endocrine Disease 1 54.08 Quite High
Starvation 10 19.40 Low Low
Stress 48 5.00 Very Low Very Low Very Low
INFLAMMATION 28 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In eight-day-old pups, yohimbine prevented the nursing-induced increase in serum GH and decreased GH levels below the saline-injected, separated control.
Positive_regulation (nursing-induced) of Positive_regulation (increase) of GH
1) Confidence 0.50 Published 1993 Journal Acta Endocrinol. Section Abstract Doc Link 8383905 Disease Relevance 0 Pain Relevance 0.46
Treatment of TPTX rats with small doses of triiodothyronine (T3) restored an episodic pattern of GH secretion, but with lower peak values than controls, as well as the GH response to clonidine.
Positive_regulation (restored) of Positive_regulation (response) of GH associated with clonidine
2) Confidence 0.49 Published 1985 Journal Neuroendocrinology Section Abstract Doc Link 2867482 Disease Relevance 0.09 Pain Relevance 0.43
In rats anesthetized with ketamine, which induces a significant increase of GH, PRL and corticosterone secretion by activating the sympathetic tone, OFQ (23 microg/rat, i.c.v.) did not modify GH and corticosterone levels, whereas again it significantly potentiated PRL secretion.
Positive_regulation (induces) of Positive_regulation (increase) of GH in sympathetic associated with ketamine
3) Confidence 0.48 Published 2002 Journal Brain Res. Section Abstract Doc Link 12031535 Disease Relevance 0 Pain Relevance 0.38
Chronic morphine exposure of male rats caused a 12-fold increase in basal GH levels and a modest rise in GH pulse frequency.
Positive_regulation (caused) of Positive_regulation (increase) of GH associated with morphine
4) Confidence 0.47 Published 1993 Journal Life Sci. Section Abstract Doc Link 8385257 Disease Relevance 0 Pain Relevance 0.69
In the second experiment, i.v. administration of 30 micrograms clonidine/kg during a GH trough period, 30 min prior to GH-releasing factor (GRF) challenge, significantly potentiated the GH response to GRF compared with rats given saline (7218.7 +/- 806.6 vs 4206.9 +/- 1068.1 ng/ml per 30 min; p < 0.05).
Positive_regulation (potentiated) of Positive_regulation (response) of GH associated with clonidine
5) Confidence 0.46 Published 1994 Journal J. Endocrinol. Section Abstract Doc Link 7913948 Disease Relevance 0 Pain Relevance 0.82
In the rats neonatally treated with MSG (4 mg/g body weight, s.c.), which causes selective destruction of the hypothalamic arcuate nucleus, plasma GH response to clonidine as well as the spontaneous GH bursts were considerably blunted, whereas prostaglandin E1 (5 micrograms/100 g body weight, i.v.) caused an abrupt increase in plasma GH levels in these animals.
Positive_regulation (caused) of Positive_regulation (increase) of GH in plasma associated with glutamate, body weight and clonidine
6) Confidence 0.46 Published 1984 Journal Neuroendocrinology Section Abstract Doc Link 6320028 Disease Relevance 0.27 Pain Relevance 0.58
Intravenous administration of the opioid receptor agonist morphine (200 micrograms/kg) caused an immediate GH burst of normal duration (63 +/- 3 min) in all animals.
Positive_regulation (caused) of Positive_regulation (immediate) of GH associated with agonist, opioid receptor and morphine
7) Confidence 0.45 Published 1996 Journal J. Endocrinol. Section Abstract Doc Link 8568462 Disease Relevance 0 Pain Relevance 0.40
In male Wistar rats morphine (3 mg/kg s.c.), and clonidine (31 micrograms/kg i.p.) induced a significant increase in plasma GH levels.
Positive_regulation (induced) of Positive_regulation (increase) of GH in plasma associated with clonidine and morphine
8) Confidence 0.45 Published 1991 Journal Neuroendocrinology Section Abstract Doc Link 1678497 Disease Relevance 0 Pain Relevance 1.05
The alpha receptor agonist clonidine (CLON) given to reserpine-pretreated animals induced a dose-dependent increase in plasma GH.
Positive_regulation (induced) of Positive_regulation (increase) of GH in plasma associated with agonist and clonidine
9) Confidence 0.45 Published 1982 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 6291085 Disease Relevance 0 Pain Relevance 0.76
Intravenous injection of chlorpromazine caused an increase of plasma GH in rats with any type of hypothalamic cut.
Positive_regulation (caused) of Positive_regulation (increase) of GH in plasma
10) Confidence 0.45 Published 1975 Journal Endocrinol. Jpn. Section Abstract Doc Link 1097237 Disease Relevance 0 Pain Relevance 0
Clonidine at various doses and by various routes (5 micrograms/kg, i.c.v.; 15 micrograms/kg, i.v., and 7, 15, 31, 125 and 250 micrograms/kg, i.p.) induced a significant increase in plasma GH levels in rats.
Positive_regulation (induced) of Positive_regulation (increase) of GH in plasma associated with clonidine
11) Confidence 0.45 Published 1990 Journal Neuroendocrinology Section Abstract Doc Link 2154719 Disease Relevance 0.33 Pain Relevance 0.70
The peptide induced a rapid, dose-dependent increase of plasma GH levels in free moving animals bearing an extensive lesion of the mediobasal hypothalamus including the median eminence.
Positive_regulation (induced) of Positive_regulation (increase) of GH in median eminence
12) Confidence 0.45 Published 1986 Journal Neuroendocrinology Section Abstract Doc Link 3097564 Disease Relevance 0 Pain Relevance 0.18
In contrast, alprazolam caused a dose-dependent increase in plasma GH when given alone to reserpine pretreated rats.
Positive_regulation (caused) of Positive_regulation (increase) of GH in plasma
13) Confidence 0.45 Published 1986 Journal Life Sci. Section Abstract Doc Link 2871466 Disease Relevance 0 Pain Relevance 0.41
Reduction of somatostatin caused enhanced GH response to GRF and no increase in basal GH level with pre-treatment of antiserum against somatostatin.
Positive_regulation (enhanced) of Positive_regulation (response) of GH associated with somatostatin
14) Confidence 0.44 Published 1993 Journal Int. J. Obes. Relat. Metab. Disord. Section Abstract Doc Link 8101181 Disease Relevance 0 Pain Relevance 0.48
Administration of antiserum against somatostatin (1 ml) plus chlorpromazine significantly elevated the basal plasma GH level and GH response to arginine in control rats, but did not elevate them in VMH lesioned rats.
Positive_regulation (elevated) of Positive_regulation (response) of GH in plasma associated with somatostatin
15) Confidence 0.44 Published 1993 Journal Int. J. Obes. Relat. Metab. Disord. Section Abstract Doc Link 8101181 Disease Relevance 0 Pain Relevance 0.44
Administration of antiserum against somatostatin (1 ml) plus chlorpromazine significantly elevated the basal plasma GH level and GH response to arginine in control rats, but did not elevate them in VMH lesioned rats.
Positive_regulation (elevated) of Positive_regulation (response) of GH in plasma associated with somatostatin
16) Confidence 0.44 Published 1993 Journal Int. J. Obes. Relat. Metab. Disord. Section Abstract Doc Link 8101181 Disease Relevance 0 Pain Relevance 0.44
Intravenous (i.v.) administration of SD33 at doses of 0.05, 0.1 and 0.2 mumol/kg stimulated a significant increase in circulating GH levels in sheep within 5 minutes post-injection.
Positive_regulation (stimulated) of Positive_regulation (increase) of GH
17) Confidence 0.43 Published 1991 Journal Life Sci. Section Abstract Doc Link 2023526 Disease Relevance 0 Pain Relevance 0
The absence of any either synergistic or at least additive effect on GH secretion of galanin and clonidine in conditions of both normal and increased somatostatin tone suggests that also in man, as well as in the rat, the action of galanin on the GH axis may be mediated through alpha-adrenergic pathways.
Spec (may) Positive_regulation (mediated) of Positive_regulation (action) of GH associated with somatostatin and clonidine
18) Confidence 0.43 Published 1994 Journal Endocr. Res. Section Abstract Doc Link 7519979 Disease Relevance 0.05 Pain Relevance 0.53
Under pentobarbital anesthesia, injection of GH-releasing factor clearly induced an increase in both plasma GH content and the number of exocytotic GH-immunopositive granules in the cells.
Positive_regulation (induced) of Positive_regulation (increase) of GH in plasma associated with anesthesia
19) Confidence 0.43 Published 1989 Journal Endocrinology Section Abstract Doc Link 2507294 Disease Relevance 0 Pain Relevance 0.10
Daily injection of alpha-FMH (20 mg/kg, s.c.) in pups of either sex, from birth until 10 days of age, caused a significant increase in baseline plasma GH and potentiated the GH response to the [Met5]-enkephalin analog FK 33-824 (1 mg/kg, s.c.) administered 3 h after the last alpha-FMH injection.
Positive_regulation (potentiated) of Positive_regulation (response) of GH in plasma associated with enkephalin
20) Confidence 0.40 Published 1996 Journal J. Endocrinol. Section Abstract Doc Link 8958779 Disease Relevance 0 Pain Relevance 0.32

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox