INT42984

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Context Info
Confidence 0.01
First Reported 1982
Last Reported 1984
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0
Pain Relevance 0.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Capns2) cytoplasm (Capns2)
Capns2 (Mus musculus)
Pain Link Frequency Relevance Heat
tetrodotoxin 5 98.70 Very High Very High Very High
sodium channel 7 87.08 High High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Binding of tetrodotoxin or batrachotoxin does not alter the spectroscopic properties of bound Css II, whereas toxin V from Leiurus quinquestriatus effects a 10-nm blue shift to a more hydrophobic environment.
Css II Binding (bound) of associated with tetrodotoxin
1) Confidence 0.01 Published 1984 Journal J. Biol. Chem. Section Abstract Doc Link 6327664 Disease Relevance 0 Pain Relevance 0.41
Under equilibrium conditions specific binding of [125I]CssII was a simple saturable function of [125I]CssII concentration, characterized by a dissociation constant of 0.4-0.7 nM and a maximum capacity of 0.9-2.4 pmol of toxin/mg of membrane protein.
CssII Binding (binding) of
2) Confidence 0.00 Published 1982 Journal Biochemistry Section Abstract Doc Link 6293551 Disease Relevance 0 Pain Relevance 0.11
None of 19 other neurotoxins or local anaesthetics known to interact with Na+ channels in excitable cells affected [125I]CssII binding, but it was completely inhibited by toxin gamma from the scorpion Tityus serrulatus serrulatus.
CssII Binding (binding) of
3) Confidence 0.00 Published 1982 Journal Biochemistry Section Abstract Doc Link 6293551 Disease Relevance 0 Pain Relevance 0.13

General Comments

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