INT4299

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Context Info
Confidence 0.50
First Reported 1975
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 27
Total Number 28
Disease Relevance 5.24
Pain Relevance 7.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gh1) signal transduction (Gh1) mitochondrion (Gh1)
extracellular space (Gh1) extracellular region (Gh1) plasma membrane (Gh1)
Anatomy Link Frequency
plasma 11
pituitary 10
Pit 4
blood 2
lateral 2
Gh1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
substance P 122 99.96 Very High Very High Very High
Inflammation 329 99.84 Very High Very High Very High
Somatostatin 52 99.44 Very High Very High Very High
Clonidine 42 99.42 Very High Very High Very High
Intracerebroventricular 8 99.20 Very High Very High Very High
tetrodotoxin 1 98.28 Very High Very High Very High
antagonist 283 96.96 Very High Very High Very High
Morphine 15 96.44 Very High Very High Very High
withdrawal 15 94.96 High High
Glutamate 94 94.44 High High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 218 100.00 Very High Very High Very High
INFLAMMATION 344 99.84 Very High Very High Very High
Eating Disorder 28 99.64 Very High Very High Very High
Body Weight 38 99.50 Very High Very High Very High
Stress 391 99.28 Very High Very High Very High
Cancer 218 98.72 Very High Very High Very High
Critical Illness 16 97.80 Very High Very High Very High
Pressure Volume 2 Under Development 8 92.88 High High
Hyperglycemia 7 92.76 High High
Disease 73 92.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
MSG-treated animals which were administered antisomatostatin serum showed elevated GH trough and mean GH levels, with no apparent effect on GH peak levels.
Positive_regulation (elevated) of Gene_expression (trough) of GH
1) Confidence 0.50 Published 1982 Journal Endocrinology Section Abstract Doc Link 6120072 Disease Relevance 0.21 Pain Relevance 0.15
In the rats neonatally treated with MSG (4 mg/g body weight, s.c.), which causes selective destruction of the hypothalamic arcuate nucleus, plasma GH response to clonidine as well as the spontaneous GH bursts were considerably blunted, whereas prostaglandin E1 (5 micrograms/100 g body weight, i.v.) caused an abrupt increase in plasma GH levels in these animals.
Positive_regulation (increase) of Gene_expression (levels) of GH in plasma associated with glutamate, body weight and clonidine
2) Confidence 0.49 Published 1984 Journal Neuroendocrinology Section Abstract Doc Link 6320028 Disease Relevance 0.27 Pain Relevance 0.58
Plasma GH levels were significantly elevated in rats with hypothalamic cuts such as complete deafferentiation, anterior cut and antero-lateral cut, whereas plasma GH levels in rats with posterior cut or postero-lateral cut were not significantly different from those in rats with sham-operation.
Positive_regulation (elevated) of Gene_expression (levels) of GH in lateral
3) Confidence 0.48 Published 1975 Journal Endocrinol. Jpn. Section Abstract Doc Link 1097237 Disease Relevance 0 Pain Relevance 0
Clonidine at various doses and by various routes (5 micrograms/kg, i.c.v.; 15 micrograms/kg, i.v., and 7, 15, 31, 125 and 250 micrograms/kg, i.p.) induced a significant increase in plasma GH levels in rats.
Positive_regulation (increase) of Gene_expression (levels) of GH in plasma associated with clonidine
4) Confidence 0.48 Published 1990 Journal Neuroendocrinology Section Abstract Doc Link 2154719 Disease Relevance 0.33 Pain Relevance 0.71
In contrast, injection of clonidine at trough times (when SRIF tone is high) consistently augmented plasma GH levels (mean +/- S.E.M. integrated GH release; 30 micrograms/kg, 1843.0 +/- 484.0; 50 micrograms/kg, 1469.0 +/- 490.3; 125 micrograms/kg, 1675.6 +/- 513.4 vs 201.3 +/- 100.1 ng/ml per 45 min in saline-injected controls; p < 0.05 or less).
Positive_regulation (augmented) of Gene_expression (levels) of GH in plasma associated with somatostatin and clonidine
5) Confidence 0.46 Published 1994 Journal J. Endocrinol. Section Abstract Doc Link 7913948 Disease Relevance 0 Pain Relevance 0.99
Circulating GH levels were significantly decreased following a brief (2 min) exposure to either, during repetitive etherization coupled with blood withdrawal, and during continuous immobilization.
Positive_regulation (Circulating) of Gene_expression (levels) of GH in blood associated with withdrawal
6) Confidence 0.45 Published 1984 Journal Proc. Soc. Exp. Biol. Med. Section Abstract Doc Link 6473349 Disease Relevance 0.38 Pain Relevance 0.52
Tetrodotoxin, a voltage-sensitive Na+ channel blocker, had no effect on either hGRF- or excess K+-induced GH secretion. cAMP production by hGRF was not greatly affected by replacing extracellular Na+.
Positive_regulation (induced) of Gene_expression (production) of GH associated with tetrodotoxin
7) Confidence 0.41 Published 1988 Journal Am. J. Physiol. Section Abstract Doc Link 2833113 Disease Relevance 0 Pain Relevance 0.14
Similarly, mice carrying a transgene expressing GH antagonist (modified bovine GH) are at reduced risk for developing mammary cancer as compared with littermates not carrying the transgene [16]; in contrast, mice overexpressing GH exhibit an increase in mammary cancer development as compared with mice with normal GH levels [17].
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of GH associated with cancer and antagonist
8) Confidence 0.41 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC468665 Disease Relevance 0.42 Pain Relevance 0.05
Discordant IGF-1 and fasting GH levels <1 ?
Positive_regulation (fasting) of Gene_expression (levels) of GH
9) Confidence 0.37 Published 2009 Journal Pituitary Section Body Doc Link PMC2855862 Disease Relevance 0.13 Pain Relevance 0
Twelve switch (41.4%) and six “other” patients (24.0%) had discordant IGF-1 and fasting GH levels <1 ?
Positive_regulation (fasting) of Gene_expression (levels) of GH
10) Confidence 0.37 Published 2009 Journal Pituitary Section Body Doc Link PMC2855862 Disease Relevance 0.38 Pain Relevance 0.12
A dose-response study for beta-endorphin indicated that 0.5 micrograms beta-endorphin was the minimum stimulatory dose for GH release, producing an approximately 4-fold increase in circulating levels of GH; lower doses of beta-endorphin did not stimulate secretion.
Positive_regulation (increase) of Gene_expression (levels) of GH
11) Confidence 0.31 Published 1994 Journal Neuroendocrinology Section Abstract Doc Link 8090284 Disease Relevance 0 Pain Relevance 0.58
Comparative studies were performed to verify the effect of growth hormone releasing hormone (GHRH) or clonidine (CLON), a compound thought to act via release of endogenous GHRH, in stimulating GH biosynthesis in the pituitary from neonatal and adult rats.
Positive_regulation (stimulating) of Gene_expression (biosynthesis) of GH in pituitary associated with clonidine
12) Confidence 0.30 Published 1986 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 3092819 Disease Relevance 0 Pain Relevance 0.35
Ex-vivo treatment with GHRH or CLON for 5 days was effective in stimulating GH biosynthesis only in the pituitary from neonatal rats.
Positive_regulation (stimulating) of Gene_expression (biosynthesis) of GH in pituitary associated with clonidine
13) Confidence 0.30 Published 1986 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 3092819 Disease Relevance 0 Pain Relevance 0.34
The acute hyperglycemic effect of KX in fed rats was associated with decreased plasma levels of insulin, adrenocorticotropic hormone (ACTH), and corticosterone and increased levels of glucagon and growth hormone (GH).
Positive_regulation (increased) of Gene_expression (levels) of GH in plasma
14) Confidence 0.27 Published 2005 Journal Exp. Biol. Med. (Maywood) Section Abstract Doc Link 16246906 Disease Relevance 0.54 Pain Relevance 0.31
Results of the present study are summarized as follows: 1) selective blockade of NE and EP synthesis with FLA-63 (20 mg/kg) caused complete suppression of episodic GH but had no significant effect on PRL release; 2) clonidine (150 microgram/kg) restored the pulsatile pattern of GH secretion in FLA-63-treated rats, and 3) clonidine (15 and 150 microgram/kg) stimulated PRL release in a dose-dependent manner.
Positive_regulation (caused) of Gene_expression (suppression) of GH associated with clonidine
15) Confidence 0.25 Published 1981 Journal Endocrinology Section Abstract Doc Link 6260466 Disease Relevance 0 Pain Relevance 0.42
In contrast, elevated levels of GH in ambulatory animals inhibit the positive affect of IGF-I, indicating that in fact elevated GH in ambulatory animals may not be permissive to elevated IGF-I function, but that improved healing from IGF-I addition is not dependent on exogenously elevated GH levels.
Positive_regulation (elevated) of Gene_expression (levels) of GH
16) Confidence 0.23 Published 2007 Journal BMC Physiol Section Body Doc Link PMC1851714 Disease Relevance 0.09 Pain Relevance 0.03
In the rats neonatally treated with MSG (4 mg/g body weight, s.c.), which causes selective destruction of the hypothalamic arcuate nucleus, plasma GH response to clonidine as well as the spontaneous GH bursts were considerably blunted, whereas prostaglandin E1 (5 micrograms/100 g body weight, i.v.) caused an abrupt increase in plasma GH levels in these animals.
Positive_regulation (increase) of in arcuate nucleus Gene_expression (levels) of GH in plasma associated with glutamate, body weight and clonidine
17) Confidence 0.17 Published 1984 Journal Neuroendocrinology Section Abstract Doc Link 6320028 Disease Relevance 0.27 Pain Relevance 0.58
GH resistance in critical illness is characterized by a rapid and sustained decrease in circulating and tissue concentrations of IGF-I despite elevated circulating levels of GH, the main effector of IGF-I secretion [8].
Positive_regulation (elevated) of Gene_expression (levels) of GH associated with critical illness
18) Confidence 0.14 Published 2007 Journal Crit Care Section Body Doc Link PMC2206515 Disease Relevance 0.30 Pain Relevance 0.17
In spite of an initial rise in GH secretion, GH action is reduced because of GH and IGF-1 resistance induced by inflammation.
Positive_regulation (induced) of Gene_expression (resistance) of GH associated with inflammation
19) Confidence 0.06 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC333413 Disease Relevance 0.60 Pain Relevance 0.14
Fasting increases plasma GH levels in all species although, in the rat, the amplitude of GH pulses is decreased but basal levels may be increased (608, 609).
Positive_regulation (increases) of Gene_expression (levels) of GH in plasma
20) Confidence 0.06 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0.07 Pain Relevance 0.03

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