INT43009

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.68
First Reported 1982
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 45
Total Number 49
Disease Relevance 7.85
Pain Relevance 10.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Scn7a)
Anatomy Link Frequency
skeletal muscle 4
neurons 3
epidermis 2
oocytes 2
dermis 2
Scn7a (Mus musculus)
Pain Link Frequency Relevance Heat
sodium channel 310 100.00 Very High Very High Very High
tetrodotoxin 258 100.00 Very High Very High Very High
Delta opioid receptors 6 100.00 Very High Very High Very High
Root ganglion neuron 10 99.98 Very High Very High Very High
Central nervous system 12 99.92 Very High Very High Very High
dorsal root ganglion 216 99.60 Very High Very High Very High
Action potential 1571 99.50 Very High Very High Very High
Pain 31 99.16 Very High Very High Very High
Hippocampus 33 98.80 Very High Very High Very High
nav1.8 3 98.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 234 99.82 Very High Very High Very High
Pain 37 99.16 Very High Very High Very High
Targeted Disruption 75 99.14 Very High Very High Very High
Nociception 62 98.24 Very High Very High Very High
Death 71 97.04 Very High Very High Very High
Adhesions 6 95.32 Very High Very High Very High
Colitis 93 93.88 High High
Injury 10 91.44 High High
Hypoxia 13 90.80 High High
Bartter Syndrome 6 88.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although Nax has not been successfully expressed in an exogenous system, recent investigations using relevant native tissues combined with gene-targeting have disclosed their unique "concentration"-sensitive but not voltage-sensitive roles.
Neg (not) Gene_expression (expressed) of Nax
1) Confidence 0.68 Published 2002 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 12046980 Disease Relevance 0.28 Pain Relevance 1.05
Compared with control cells, the Na+ currents of converted cells were more resistant to block by tetrodotoxin, suggesting enhanced relative expression of the cardiac Na+ channel isoform Na(v)1.5 compared with the skeletal muscle isoform Na(v)1.4.
Gene_expression (expression) of Na in skeletal muscle associated with tetrodotoxin
2) Confidence 0.66 Published 2004 Journal Am. J. Physiol., Cell Physiol. Section Abstract Doc Link 15044148 Disease Relevance 0 Pain Relevance 0.10
These findings and reverse transcription PCR experiments suggest that an upregulation of the expression of the cardiac sodium channel isoform Na(v)1.5 versus the skeletal muscle isoform Na(v)1.4 is responsible for the observed changes in sodium current function.
Gene_expression (expression) of Na in skeletal muscle associated with sodium channel
3) Confidence 0.52 Published 2007 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 16980339 Disease Relevance 0.05 Pain Relevance 0.19
These findings and reverse transcription PCR experiments suggest that an upregulation of the expression of the cardiac sodium channel isoform Na(v)1.5 versus the skeletal muscle isoform Na(v)1.4 is responsible for the observed changes in sodium current function.
Gene_expression (expression) of Na in skeletal muscle associated with sodium channel
4) Confidence 0.52 Published 2007 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 16980339 Disease Relevance 0.05 Pain Relevance 0.19
Compared with control cells, the Na+ currents of converted cells were more resistant to block by tetrodotoxin, suggesting enhanced relative expression of the cardiac Na+ channel isoform Na(v)1.5 compared with the skeletal muscle isoform Na(v)1.4.
Gene_expression (expression) of Na in skeletal muscle associated with tetrodotoxin
5) Confidence 0.51 Published 2004 Journal Am. J. Physiol., Cell Physiol. Section Abstract Doc Link 15044148 Disease Relevance 0 Pain Relevance 0.10
Na and Ca spikes produced by ions passing through Ca channels in mouse ovarian oocytes.
Gene_expression (produced) of Na in oocytes
6) Confidence 0.48 Published 1982 Journal Pflugers Arch. Section Title Doc Link 6294589 Disease Relevance 0 Pain Relevance 0.18
The direction of Na+ transfer, investigated in the absence of Na+ channel blockers, established that active transport of Na+ occurs across the frogs bladder membrane from the internal to the external face.
Gene_expression (transfer) of Na in bladder
7) Confidence 0.47 Published 1998 Journal Toxicon Section Abstract Doc Link 9723836 Disease Relevance 0 Pain Relevance 0.38
Small dorsal root ganglion neurons express preferentially the Na+ channel isoform Na(v)1.9 that mediates a tetrodotoxin-resistant (TTX-R) Na+ current.
Gene_expression (express) of Na in neurons associated with ganglion cysts, tetrodotoxin and root ganglion neuron
8) Confidence 0.44 Published 2004 Journal Pflugers Arch. Section Abstract Doc Link 15290301 Disease Relevance 0.17 Pain Relevance 0.26
Small dorsal root ganglion neurons express preferentially the Na+ channel isoform Na(v)1.9 that mediates a tetrodotoxin-resistant (TTX-R) Na+ current.
Gene_expression (express) of Na in neurons associated with ganglion cysts, tetrodotoxin and root ganglion neuron
9) Confidence 0.38 Published 2004 Journal Pflugers Arch. Section Abstract Doc Link 15290301 Disease Relevance 0.17 Pain Relevance 0.26
Furthermore, we co-expressed DOR and Na+ channels in Xenopus oocytes and showed that DOR expression and activation indeed play an inhibitory role in Na+ channel regulation by decreasing the amplitude of sodium currents and increasing activation threshold of Na+ channels.
Gene_expression (expressed) of Na in oocytes associated with delta opioid receptors
10) Confidence 0.21 Published 2009 Journal Cell. Mol. Life Sci. Section Abstract Doc Link 19756387 Disease Relevance 0.56 Pain Relevance 0.42
TTX-sensitive voltage-gated Na+ channels are expressed in mesenteric artery smooth muscle cells.
Gene_expression (expressed) of Na in artery smooth muscle
11) Confidence 0.19 Published 2005 Journal Am. J. Physiol. Heart Circ. Physiol. Section Title Doc Link 15961372 Disease Relevance 0 Pain Relevance 0.07
In addition, all cells expressed significant tetrodotoxin (TTX)-sensitive Na+ currents.
Gene_expression (expressed) of Na associated with tetrodotoxin
12) Confidence 0.15 Published 1995 Journal Glia Section Abstract Doc Link 8567069 Disease Relevance 0 Pain Relevance 0.10
4 M ouabain (Merck) in order to inhibit Na+/K+ATPase activity, with or without 3 × 10?
Gene_expression (/) of Na
13) Confidence 0.07 Published 2008 Journal The Journal of General Physiology Section Body Doc Link PMC2483333 Disease Relevance 0 Pain Relevance 0.10
Another compensatory mechanism may be causing an increased activity and expression of the Na+/K+ATPase in order to counteract the [Na+]i overload in mdx muscle (Dunn et al., 1995).
Gene_expression (expression) of Na in muscle
14) Confidence 0.07 Published 2008 Journal The Journal of General Physiology Section Body Doc Link PMC2483333 Disease Relevance 0.18 Pain Relevance 0
So far, six types of Na+ channel ?
Gene_expression (types) of Na
15) Confidence 0.06 Published 2008 Journal Prog Biophys Mol Biol Section Body Doc Link PMC2764399 Disease Relevance 0.29 Pain Relevance 0
Experiments using CHO and 1610 cell lines have demonstrated a 2- to 4-fold greater Na+ channel expression when ?
Gene_expression (expression) of Na
16) Confidence 0.06 Published 2008 Journal Prog Biophys Mol Biol Section Body Doc Link PMC2764399 Disease Relevance 0.32 Pain Relevance 0
-subunits have been shown to regulate the expression density of the Na+ channel in the plasma membrane.
Gene_expression (expression) of Na in plasma
17) Confidence 0.06 Published 2008 Journal Prog Biophys Mol Biol Section Body Doc Link PMC2764399 Disease Relevance 0.26 Pain Relevance 0
In particular, Na+ overload in mdx5cv fibers significantly contributes to cell degradation and early death.
Gene_expression (overload) of Na associated with death
18) Confidence 0.06 Published 2008 Journal The Journal of General Physiology Section Body Doc Link PMC2483333 Disease Relevance 0.53 Pain Relevance 0.32
Another important observation, producing even more significant effect on basal Na+ entry, is the shift of the inactivation threshold by ?
Gene_expression (entry) of Na
19) Confidence 0.06 Published 2008 Journal The Journal of General Physiology Section Body Doc Link PMC2483333 Disease Relevance 0 Pain Relevance 0
The calculations were done for the individual traces and then calculated concentrations were averaged to produce overall [Na+] levels, yielding 9.3 ± 2 mM for control C57BL/6J fibers and 18.1 ± 4 mM for mdx5cv fibers.


Gene_expression (produce) of Na
20) Confidence 0.06 Published 2008 Journal The Journal of General Physiology Section Body Doc Link PMC2483333 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox