INT43019

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Context Info
Confidence 0.26
First Reported 1982
Last Reported 2010
Negated 0
Speculated 3
Reported most in Abstract
Documents 4
Total Number 7
Disease Relevance 2.46
Pain Relevance 1.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PHGDH) small molecule metabolic process (PHGDH) oxidoreductase activity (PHGDH)
cellular nitrogen compound metabolic process (PHGDH)
Anatomy Link Frequency
Th2 cells 1
urine 1
PHGDH (Homo sapiens)
Pain Link Frequency Relevance Heat
narcan 10 100.00 Very High Very High Very High
opiate 8 100.00 Very High Very High Very High
Analgesic 1 96.24 Very High Very High Very High
Morphine 4 95.08 Very High Very High Very High
cINOD 3 91.12 High High
Opioid 1 91.00 High High
aspirin 1 80.56 Quite High
diclofenac 1 79.04 Quite High
antidepressant 1 78.08 Quite High
Inflammatory marker 1 77.20 Quite High
Disease Link Frequency Relevance Heat
Nicotine Addiction 186 100.00 Very High Very High Very High
Breast Cancer 4 99.32 Very High Very High Very High
Infection 5 95.04 Very High Very High Very High
Fever 79 91.24 High High
Reprotox - General 1 10 91.16 High High
INFLAMMATION 31 90.92 High High
Bacterial Infection 1 83.08 Quite High
Syndrome 35 82.24 Quite High
Alzheimer's Dementia 2 65.96 Quite High
Canker Sores 4 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this study, we present evidence demonstrating that the novel PGD(2) receptor chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2) is another functional target for indomethacin.
Regulation (target) of PGD in Th2 cells
1) Confidence 0.26 Published 2002 Journal J. Immunol. Section Abstract Doc Link 11801628 Disease Relevance 0.17 Pain Relevance 0.25
Trazodone influence on rat sera beta-endorphins level.
Regulation (influence) of sera
2) Confidence 0.26 Published 2004 Journal Bosn J Basic Med Sci Section Title Doc Link 15629021 Disease Relevance 0 Pain Relevance 0.41
Even at these low concentrations there was a significant difference in procalcitonin levels between FP sera and AFP/control sera.
Regulation (control) of sera
3) Confidence 0.19 Published 2010 Journal BMC Pediatr Section Body Doc Link PMC2944328 Disease Relevance 0.88 Pain Relevance 0.04
The effects of ETS exposure on daily urinary PdG and E1C levels in a ±10 day window around the day of ovulation were analyzed for conception and nonconception cycles, respectively.
Spec (analyzed) Regulation (effects) of PdG associated with nicotine addiction
4) Confidence 0.18 Published 2005 Journal Environ Health Perspect Section Abstract Doc Link PMC1278480 Disease Relevance 0.93 Pain Relevance 0
All PdG, E1C, and hCG values were normalized to creatinine values to adjusted for urine concentration.
Regulation (values) of PdG in urine
5) Confidence 0.18 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1278480 Disease Relevance 0.13 Pain Relevance 0
The effects of administration of opiates and naloxone on the activities of PFK, 6PGDH and alpha-GPDH and alpha-GPDH/6PGDH ratios in human breast carcinomas were investigated in patients awaiting mastectomy.
Spec (investigated) Regulation (effects) of 6PGDH associated with breast cancer, narcan and opiate
6) Confidence 0.09 Published 1982 Journal Tumori Section Abstract Doc Link 6294937 Disease Relevance 0.17 Pain Relevance 0.41
The effects of administration of opiates and naloxone on the activities of PFK, 6PGDH and alpha-GPDH and alpha-GPDH/6PGDH ratios in human breast carcinomas were investigated in patients awaiting mastectomy.
Spec (investigated) Regulation (effects) of 6PGDH associated with breast cancer, narcan and opiate
7) Confidence 0.03 Published 1982 Journal Tumori Section Abstract Doc Link 6294937 Disease Relevance 0.17 Pain Relevance 0.42

General Comments

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