INT43045

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Context Info
Confidence 0.12
First Reported 1982
Last Reported 2000
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.17
Pain Relevance 1.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Npr1) intracellular (Npr1)
Anatomy Link Frequency
neurons 2
hearts 2
vas deferens 2
Npr1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 6 99.18 Very High Very High Very High
opiate 4 99.12 Very High Very High Very High
antagonist 4 94.48 High High
adenocard 4 94.16 High High
narcan 2 93.60 High High
agonist 2 92.96 High High
Opioid 1 87.64 High High
Enkephalin 2 84.00 Quite High
opioid receptor 3 75.00 Quite High
Nucleus accumbens 2 75.00 Quite High
Disease Link Frequency Relevance Heat
Hypertrophy 1 99.72 Very High Very High Very High
Coronary Heart Disease 7 75.00 Quite High
Hypertension 2 25.00 Low Low
Fistula 1 25.00 Low Low
Pressure And Volume Under Development 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus chronic D1 blockade, like chronic morphine treatment, appears to cause a selective impairment of the regulation of adenylyl cyclase in A2a receptor-expressing striato-pallidal neurons.
Negative_regulation (impairment) of Regulation (regulation) of cyclase in neurons associated with morphine
1) Confidence 0.12 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9353370 Disease Relevance 0 Pain Relevance 1.03
Both peptides were shown a) to bind with high affinity to the opiate receptors of rat brain membranes and b) to inhibit strongly the contractions of electrically stimulated vas deferens and the adenyl cyclase of the NG 108-15 cell membranes.
Negative_regulation (inhibit) of Regulation (contractions) of cyclase in vas deferens associated with opiate
2) Confidence 0.07 Published 1982 Journal Life Sci. Section Abstract Doc Link 6296569 Disease Relevance 0 Pain Relevance 0.62
These results suggest that the decreased expression of G(s)alpha proteins may not be the cause but the effect of hypertrophy and that the diminished responsiveness of adenylyl cyclase to GTPgammaS, isoproterenol, NaF, and forskolin in hearts from AV shunt rats may partly be due to the decreased expression of G(s)alpha.
Negative_regulation (diminished) of Regulation (responsiveness) of cyclase in hearts associated with hypertrophy
3) Confidence 0.06 Published 2000 Journal Am. J. Physiol., Cell Physiol. Section Abstract Doc Link 11003579 Disease Relevance 0.17 Pain Relevance 0

General Comments

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