INT43063

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Context Info
Confidence 0.49
First Reported 1982
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 18
Disease Relevance 1.57
Pain Relevance 7.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Cux1) nucleus (Cux1) protein binding, bridging (Cux1)
DNA binding (Cux1) cytoplasm (Cux1)
Anatomy Link Frequency
brain 1
prefrontal 1
Cux1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antidepressant 1328 99.98 Very High Very High Very High
Opioid 10 99.84 Very High Very High Very High
depression 307 98.18 Very High Very High Very High
fluoxetine 176 97.80 Very High Very High Very High
sSRI 128 97.58 Very High Very High Very High
Desipramine 96 96.68 Very High Very High Very High
Morphine 5 95.64 Very High Very High Very High
Potency 16 92.32 High High
Antinociceptive 1 87.32 High High
agonist 176 84.48 Quite High
Disease Link Frequency Relevance Heat
Toxicity 16 98.20 Very High Very High Very High
Depression 304 98.18 Very High Very High Very High
Stress 5 84.64 Quite High
Urological Neuroanatomy 32 81.60 Quite High
Respiratory Failure 3 75.00 Quite High
Anxiety Disorder 18 66.96 Quite High
Disease 48 35.84 Quite Low
Affective Disorder 32 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 32 5.00 Very Low Very Low Very Low
Suicidal Behaviour 16 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Accumulation of CDP-diacylglycerol was measured in brain slice preparations by taking advantage of the CTP-phosphatidate transfer reaction as previously described in detail [75-77].
Positive_regulation (Accumulation) of CDP in brain
1) Confidence 0.49 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2245968 Disease Relevance 0 Pain Relevance 0.07
Conversely, other MAO inhibitors, including phenelzine, hydralazine and tranylcypromine were significantly effective in inducing CDP-DG.
Positive_regulation (inducing) of CDP
2) Confidence 0.49 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2245968 Disease Relevance 0.10 Pain Relevance 0.26
Antidepressants elicit greater stimulation of CDP-diacylglycerol production than IP formation
Positive_regulation (stimulation) of CDP associated with antidepressant
3) Confidence 0.40 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2245968 Disease Relevance 0 Pain Relevance 0.51
Hence, to the extent that CDP-DG production might be relevant to depression or the mechanism of antidepressant drug action, an antidepressive agent should not merely increase PI hydrolysis, but the CDP-DG produced must exceed and probably precede the production of PI messengers.
Neg (not) Positive_regulation (increase) of CDP associated with antidepressant and depression
4) Confidence 0.40 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2245968 Disease Relevance 0.15 Pain Relevance 0.76
The antagonism of the anticonflict effect of chlordiazepoxide (CDP) by beta-carboline carboxylic acid ethyl ester (BCCE), Ro 15-1788 and ACTH(4--10) has been evaluated in the Geller-Seifter rat conflict test in which CDP increases punished (conflict), but not unpunished responding.
Positive_regulation (increases) of CDP
5) Confidence 0.40 Published 1982 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 6296901 Disease Relevance 0 Pain Relevance 0
Measurement of CDP-diacylglycerol accumulation
Positive_regulation (Measurement) of CDP
6) Confidence 0.35 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2245968 Disease Relevance 0.05 Pain Relevance 0.10
As shown in Figure 7, LiCl did not significantly enhance or inhibit antidepressant drug-induced CDP-DG production, implying that the presence of Li+ is not necessary to demonstrate the enhancing effects of antidepressant agents on CDP-DG production.


Positive_regulation (induced) of CDP associated with antidepressant
7) Confidence 0.35 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2245968 Disease Relevance 0 Pain Relevance 0.50
The classical antidepressants imipramine and desipramine, the selective serotonin reuptake inhibitors fluoxetine and paroxetine, and the atypical agents maprotiline and nomifensine, each significantly and dose-dependently enhanced the accumulation of [3H]CDP-DG in rat hippocampal, prefrontal cortical, and striatal slices (Figure 1).
Positive_regulation (enhanced) of CDP in prefrontal associated with desipramine, antidepressant, ssri and fluoxetine
8) Confidence 0.35 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2245968 Disease Relevance 0.06 Pain Relevance 0.46
MAOIs that were effective in inducing CDP-DG production also showed enhanced effects on PI resynthesis (Figure 3), whereas other MAOIs that were ineffective on CDP-DG were equally ineffective in increasing PI resynthesis (data not shown).
Positive_regulation (inducing) of CDP
9) Confidence 0.35 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2245968 Disease Relevance 0.08 Pain Relevance 0.26
To estimate the extent to which antidepressant-enhanced CDP-DG may derive from PI breakdown, we blocked PI hydrolysis and then measured the consequent effects on the ability of antidepressant agents to induce CDP-DG accumulation.
Positive_regulation (induce) of CDP associated with antidepressant
10) Confidence 0.35 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2245968 Disease Relevance 0.08 Pain Relevance 0.42
Antidepressant-induced CDP-diacylglycerol formation partially depends on PI hydrolysis
Positive_regulation (induced) of CDP associated with antidepressant
11) Confidence 0.35 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2245968 Disease Relevance 0.10 Pain Relevance 0.33
To estimate the extent to which antidepressant-enhanced CDP-DG may derive from PI breakdown, we blocked PI hydrolysis and then measured the consequent effects on the ability of antidepressant agents to induce CDP-DG accumulation.
Positive_regulation (enhanced) of CDP associated with antidepressant
12) Confidence 0.35 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2245968 Disease Relevance 0.09 Pain Relevance 0.41
The MAOI data (Figure 3) also depict the significantly greater relative accumulation of PIs compared to the accumulation of CDP-DG, implying the conversion of CDP-DG to PI may be a dynamic or cumulative process.
Positive_regulation (accumulation) of CDP
13) Confidence 0.35 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2245968 Disease Relevance 0.07 Pain Relevance 0.15
Chemically diverse antidepressant agents increase CDP-diacylglycerol production
Positive_regulation (increase) of CDP associated with antidepressant
14) Confidence 0.35 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2245968 Disease Relevance 0.10 Pain Relevance 0.30
After testing a wide range of compounds, we observed that neither the antipsychotics chlorpromazine and haloperidol, nor several other psychotropic agents were capable of inducing the degree of CDP-DG effects observed with the antidepressant agents.
Positive_regulation (inducing) of CDP associated with antidepressant
15) Confidence 0.35 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2245968 Disease Relevance 0.06 Pain Relevance 0.27
Antidepressant-induced CDP-diacylglycerol formation translates into increased PI synthesis
Positive_regulation (induced) of CDP associated with antidepressant
16) Confidence 0.35 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2245968 Disease Relevance 0.10 Pain Relevance 0.72
As shown in Figure 6, U73122 by itself did not significantly alter basal CDP-DG production (Figure 6A) or IP accumulation (Figure 6B), although a slight increase in IP was consistently noted.
Positive_regulation (increase) of CDP
17) Confidence 0.35 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2245968 Disease Relevance 0.05 Pain Relevance 0.41
A CDP potentiation was also observed for the short-lasting raises in PaCO2 with the lowest concentrations of the opioids.
Positive_regulation (potentiation) of CDP associated with opioid
18) Confidence 0.29 Published 1998 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 9512069 Disease Relevance 0.48 Pain Relevance 1.22

General Comments

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