INT43084

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Context Info
Confidence 0.46
First Reported 1982
Last Reported 2011
Negated 4
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 4.70
Pain Relevance 1.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Ace) peptidase activity (Ace) extracellular space (Ace)
extracellular region (Ace) plasma membrane (Ace)
Anatomy Link Frequency
brain 2
muscle 1
central nervous system 1
Ace (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 15 98.48 Very High Very High Very High
Inflammation 67 98.40 Very High Very High Very High
cytokine 39 97.36 Very High Very High Very High
Central nervous system 1 97.04 Very High Very High Very High
metalloproteinase 52 95.84 Very High Very High Very High
bradykinin 5 89.12 High High
Neuropeptide 4 87.24 High High
antagonist 15 86.80 High High
substance P 3 85.88 High High
Dynorphin 1 85.36 High High
Disease Link Frequency Relevance Heat
Myocardial Infarction 25 99.96 Very High Very High Very High
Disease 61 98.82 Very High Very High Very High
INFLAMMATION 69 98.40 Very High Very High Very High
Appetite Loss 94 97.92 Very High Very High Very High
Cancer 77 97.56 Very High Very High Very High
Death 18 91.56 High High
Ureteral Obstruction 42 90.24 High High
Stroke 7 89.64 High High
Hypertension 7 88.32 High High
Renal Disease 38 87.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Angiotensin-converting enzyme (ACE) interacts with dopaminergic mechanisms in the brain to modulate prepulse inhibition in mice.
ACE Binding (interacts) of in brain
1) Confidence 0.46 Published 2005 Journal Neurosci. Lett. Section Title Doc Link 15854741 Disease Relevance 0.34 Pain Relevance 0.36
Our past clinical research also proved that ACEI preparation Fosinopril can inhibit NF-?
ACE Neg (inhibit) Binding (inhibit) of
2) Confidence 0.36 Published 2010 Journal Clinical Medicine Insights. Cardiology Section Body Doc Link PMC2956475 Disease Relevance 0.66 Pain Relevance 0.23
Ang I is converted to the active peptide, angiotensin II (Ang II), by membrane bound ACE.
ACE Binding (bound) of
3) Confidence 0.35 Published 2010 Journal Cardiovasc Drugs Ther Section Body Doc Link PMC2887501 Disease Relevance 0.11 Pain Relevance 0
A parallel study, the TRANSCEND study, which stands for Telmisartan Randomised AssessmeNt Study in ACE-iNtolerant subjects with cardiovascular Disease, compares telmisartan against placebo in patients who are intolerant to ACE inhibitors and is scheduled to be reported at about the same time (Yusuf 2002).
ACE Binding (intolerant) of associated with disease
4) Confidence 0.32 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350139 Disease Relevance 0.82 Pain Relevance 0
Differential recognition of both brain enkephalinase and angiotensin-converting enzyme (ACE) catalytic sites by these carboxylalkyl compounds lead to potent (KI approximately 0.5 microM), competitive and selective inhibitors of the enkephalin-degrading enzyme.
ACE Binding (recognition) of in brain associated with enkephalin
5) Confidence 0.28 Published 1983 Journal J. Med. Chem. Section Abstract Doc Link 6298420 Disease Relevance 0 Pain Relevance 0.48
Therefore the differential recognition of active sites of both peptidases leads to: i) N-(carboxymethyl)-L-Phe-L-Leu, 5, a competitive inhibitor of "enkephalinase" (KI = 0.7 microM) and ACE (KI = 1.2 microM) which could be used as mixed inhibitor for both enzymes; ii) N-[(R,S)-2-carboxy, 3-benzylpropanoyl]-L-Leucine, 3, a full competitive inhibitor of "enkephalinase" (KI = 0.34 microM) which does not interact with ACE (IC50 greater than 10,000 microM).
ACE Neg (not) Binding (interact) of
6) Confidence 0.27 Published 1982 Journal Life Sci. Section Abstract Doc Link 6298535 Disease Relevance 0 Pain Relevance 0.12
B inhibitors, ACE inhibition, statins, glucocorticoids and antioxidants) attenuates renal inflammation [4], [18], [26].
ACE Neg (inhibition) Binding (inhibition) of associated with inflammation
7) Confidence 0.11 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2672164 Disease Relevance 0.90 Pain Relevance 0.28
Somatic ACE (180?
ACE Binding (Somatic) of
8) Confidence 0.09 Published 2011 Journal Biochemistry Research International Section Body Doc Link PMC2989646 Disease Relevance 0.38 Pain Relevance 0.08
In CHF, inhibition of the angiotensin-converting enzyme (ACE) by administration of enalapril reduces the risk of weight loss and it is linked to improved survival.93 Preliminary results demonstrate increased subcutaneous fat (increased skin fold thickness) and greater muscle bulk (increased mid-upper arm and tight circumferences), together with a significant elevation in plasma albumin and hematocrit.94 ACE inhibitors, like captopril, seem to act by decreasing the production of TNF-?
ACE Neg (inhibition) Binding (inhibition) of in muscle associated with appetite loss and myocardial infarction
9) Confidence 0.06 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004581 Disease Relevance 1.49 Pain Relevance 0
We have found activity of dipeptidyl peptidase (DPP) III, one of the most important enkephalin-degrading enzymes in the central nervous system, in human neutrophils.
dipeptidyl peptidase Binding (activity) of in central nervous system associated with central nervous system and enkephalin
10) Confidence 0.01 Published 2000 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 10873616 Disease Relevance 0 Pain Relevance 0.38

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