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Context Info
Confidence 0.30
First Reported 1982
Last Reported 2010
Negated 0
Speculated 0
Reported most in Title
Documents 3
Total Number 3
Disease Relevance 1.51
Pain Relevance 0.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Ace) peptidase activity (Ace) extracellular space (Ace)
extracellular region (Ace) plasma membrane (Ace)
Ace (Mus musculus)
Pain Link Frequency Relevance Heat
cOX1 1 99.60 Very High Very High Very High
COX2 1 99.60 Very High Very High Very High
beta blocker 2 97.94 Very High Very High Very High
cINOD 1 96.96 Very High Very High Very High
Inflammation 16 82.96 Quite High
Enkephalin 2 81.88 Quite High
ischemia 1 51.96 Quite High
COX-2 inhibitor 3 34.68 Quite Low
Bioavailability 1 27.20 Quite Low
cva 13 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 45 99.08 Very High Very High Very High
Coronary Heart Disease 3 98.64 Very High Very High Very High
INFLAMMATION 19 96.24 Very High Very High Very High
Diabetes Mellitus 9 94.32 High High
Metabolic Syndrome 4 93.76 High High
Hyperlipidemia 2 92.56 High High
Pressure And Volume Under Development 10 91.92 High High
Nicotine Addiction 9 91.08 High High
Thrombosis Related Under Development 10 77.76 Quite High
Disease 12 66.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, IC50 values against "enkephalinase" were found in the same range whatever the length of the chain bearing the carboxyl group whereas a well-defined position of this group with respect to the Zn atom is required for strong ACE inhibition.
Positive_regulation (required) of Negative_regulation (inhibition) of ACE
1) Confidence 0.30 Published 1982 Journal Life Sci. Section Abstract Doc Link 6298535 Disease Relevance 0 Pain Relevance 0.16
In addition, the use of beta blockers for patients with coronary disease and antiplatelet therapy as well as angiotensin-converting enzyme (ACE) inhibitors are recommended for all patients with peripheral vascular disease.
Positive_regulation (recommended) of Negative_regulation (inhibitors) of ACE associated with beta blocker, increased venous pressure under development and coronary heart disease
2) Confidence 0.22 Published 2010 Journal The Open Neurology Journal Section Body Doc Link PMC2923338 Disease Relevance 1.41 Pain Relevance 0.12
Prostaglandins that increase renin production in response to ACE inhibition are not derived from cyclooxygenase-1.
Positive_regulation (increase) of Negative_regulation (inhibition) of ACE associated with cox1
3) Confidence 0.17 Published 2002 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Title Doc Link 12184998 Disease Relevance 0.10 Pain Relevance 0.20

General Comments

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