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Context Info
Confidence 0.26
First Reported 1982
Last Reported 1982
Negated 1
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0.12

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peptidase activity (Ace, Mme) plasma membrane (Ace, Mme) endosome (Ace)
extracellular space (Ace) extracellular region (Ace)
Ace (Mus musculus)
Mme (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 2 61.36 Quite High


Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore the differential recognition of active sites of both peptidases leads to: i) N-(carboxymethyl)-L-Phe-L-Leu, 5, a competitive inhibitor of "enkephalinase" (KI = 0.7 microM) and ACE (KI = 1.2 microM) which could be used as mixed inhibitor for both enzymes; ii) N-[(R,S)-2-carboxy, 3-benzylpropanoyl]-L-Leucine, 3, a full competitive inhibitor of "enkephalinase" (KI = 0.34 microM) which does not interact with ACE (IC50 greater than 10,000 microM).
ACE Neg (not) Binding (interact) of enkephalinase
1) Confidence 0.26 Published 1982 Journal Life Sci. Section Abstract Doc Link 6298535 Disease Relevance 0 Pain Relevance 0.12

General Comments

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