INT4311

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Context Info
Confidence 0.44
First Reported 1976
Last Reported 2000
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 1.24
Pain Relevance 1.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Ces2a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
fluoxetine 4 99.84 Very High Very High Very High
antidepressant 1 98.98 Very High Very High Very High
Chronic pancreatitis 1 97.56 Very High Very High Very High
depression 2 95.44 Very High Very High Very High
Morphine 3 94.96 High High
dexamethasone 3 89.32 High High
headache 2 81.80 Quite High
cINOD 1 67.84 Quite High
Potency 1 65.20 Quite High
Disease Link Frequency Relevance Heat
Pancreatitis 4 98.76 Very High Very High Very High
Avian Sarcoma 1 95.56 Very High Very High Very High
Depression 4 95.44 Very High Very High Very High
Mental Disorders 1 89.44 High High
Confusion 1 82.24 Quite High
Headache 1 81.80 Quite High
Renal Failure 1 75.00 Quite High
INFLAMMATION 1 67.64 Quite High
Renal Disease 2 67.04 Quite High
Drug Induced Neurotoxicity 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Postulated mechanisms for this drug interaction, particularly CYP450 isoenzyme inhibition by fluoxetine, is discussed.
Negative_regulation (inhibition) of CYP450 isoenzyme associated with fluoxetine
1) Confidence 0.44 Published 2000 Journal Ann Clin Psychiatry Section Abstract Doc Link 10984007 Disease Relevance 0.35 Pain Relevance 0.40
The L-type isoenzyme is selectively suppressed while the M-type isoenzyme is not altered to any significant extent with a consequent lowering of the L/M ratio. 3.
Negative_regulation (suppressed) of L-type isoenzyme
2) Confidence 0.14 Published 1982 Journal Int. J. Biochem. Section Abstract Doc Link 7067901 Disease Relevance 0 Pain Relevance 0.28
Coadministration of antidepressant agents such as nefazodone, or any other drug that inhibits the CYP3A4 isoenzyme subfamily, should be anticipated to interfere with tacrolimus metabolism.
Negative_regulation (inhibits) of CYP3A4 isoenzyme associated with antidepressant
3) Confidence 0.01 Published 1998 Journal Pharmacotherapy Section Abstract Doc Link 9855339 Disease Relevance 0.45 Pain Relevance 0.17
Drug inhibition and cellular regulation of prostaglandin G/H synthase isoenzyme 2.
Negative_regulation (inhibition) of synthase isoenzyme 2
4) Confidence 0.00 Published 1993 Journal J Lipid Mediat Section Title Doc Link 8357977 Disease Relevance 0.16 Pain Relevance 0.19
Moreover, P3 isoenzyme activity declined during apparent recovery from pancreatitis.
Negative_regulation (declined) of P3 isoenzyme associated with pancreatitis
5) Confidence 0.00 Published 1976 Journal Clin. Chem. Section Abstract Doc Link 1106910 Disease Relevance 0.27 Pain Relevance 0.10

General Comments

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