INT43117

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Context Info
Confidence 0.38
First Reported 1983
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.14
Pain Relevance 0.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Phax) RNA binding (Phax) nucleus (Phax)
cytoplasm (Phax)
Phax (Rattus norvegicus)
Pain Link Frequency Relevance Heat
monoamine 1 94.36 High High
opiate 1 93.76 High High
Pain 10 73.52 Quite High
analgesia 10 51.84 Quite High
withdrawal 48 50.00 Quite Low
c fibre 40 50.00 Quite Low
Adelta 8 50.00 Quite Low
Spinal cord 8 45.20 Quite Low
qutenza 6 5.00 Very Low Very Low Very Low
agonist 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pain 13 73.52 Quite High
Nociception 20 62.68 Quite High
Body Weight 3 5.00 Very Low Very Low Very Low
Neuropathic Pain 3 5.00 Very Low Very Low Very Low
INFLAMMATION 3 5.00 Very Low Very Low Very Low
Hypoalagesia 2 5.00 Very Low Very Low Very Low
Peripheral Arterial Disease 2 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 1 5.00 Very Low Very Low Very Low
Sleep Disorders 1 5.00 Very Low Very Low Very Low
Nervous System Injury 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In its native configuration, beta-RTX was not susceptible to tryptic degradation but was readily digested after reduction and alkylation. beta-RTX possesses weak phospholipase A2 activity and competes with the binding of monoamines and opiate ligands to their respective receptors.
Protein_catabolism (degradation) of beta-RTX associated with opiate and monoamine
1) Confidence 0.38 Published 1983 Journal J. Biol. Chem. Section Abstract Doc Link 6300128 Disease Relevance 0 Pain Relevance 0.14
RTX administration
Protein_catabolism (administration) of RTX
2) Confidence 0.25 Published 2010 Journal Mol Pain Section Body Doc Link PMC3019206 Disease Relevance 0.14 Pain Relevance 0.13

General Comments

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