INT43127

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Context Info
Confidence 0.49
First Reported 1983
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 3.25
Pain Relevance 1.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (TNFRSF10B)
TNFRSF10B (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 1 98.64 Very High Very High Very High
cINOD 13 97.92 Very High Very High Very High
narcan 2 97.84 Very High Very High Very High
Enkephalin 5 97.40 Very High Very High Very High
agonist 56 92.96 High High
Inflammation 3 75.00 Quite High
antagonist 46 74.92 Quite High
Neuropeptide 3 73.80 Quite High
COX2 1 25.00 Low Low
qutenza 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 290 99.24 Very High Very High Very High
Renal Cancer 4 97.20 Very High Very High Very High
Glioblastoma 2 92.32 High High
Neuroblastoma 2 90.96 High High
Death 57 90.52 High High
Colon Cancer 24 89.04 High High
Reprotox - General 1 8 85.64 High High
Leukemia 10 84.40 Quite High
INFLAMMATION 4 75.00 Quite High
Lung Cancer 16 57.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The enhancement of NK activity with beta-endorphin increased at all E:T ratios tested.
Positive_regulation (increased) of Positive_regulation (enhancement) of NK
1) Confidence 0.49 Published 1983 Journal J. Immunol. Section Abstract Doc Link 6300232 Disease Relevance 0 Pain Relevance 0.68
We further show that sulindac sulfide and SC-'236-induced DR5 upregulation occurs independent of the COX inhibitory effects of these NSAIDs.
Positive_regulation (induced) of Positive_regulation (upregulation) of DR5 associated with cinod
2) Confidence 0.45 Published 2002 Journal Oncogene Section Abstract Doc Link 12203115 Disease Relevance 1.06 Pain Relevance 0.46
suggesting that ROS-mediated transcriptional activation of DR5 is important for
Positive_regulation (suggesting) of Positive_regulation (activation) of DR5
3) Confidence 0.25 Published 2008 Journal PPAR Research Section Body Doc Link PMC2442903 Disease Relevance 1.25 Pain Relevance 0.03
As well, DR5 upregulation contributes to the sensitization of TRAIL-induced
Positive_regulation (contributes) of Positive_regulation (upregulation) of DR5
4) Confidence 0.22 Published 2008 Journal PPAR Research Section Body Doc Link PMC2442903 Disease Relevance 0.95 Pain Relevance 0.08

General Comments

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