INT43141

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Context Info
Confidence 0.14
First Reported 1983
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.26
Pain Relevance 0.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

molecular_function (Hrasls) cytoplasm (Hrasls)
Hrasls (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 22 99.44 Very High Very High Very High
Potency 2 97.72 Very High Very High Very High
narcan 2 94.40 High High
Enkephalin 1 93.88 High High
agonist 13 79.00 Quite High
Pain 2 62.24 Quite High
cytokine 68 50.00 Quite Low
cINOD 1 44.92 Quite Low
antagonist 8 5.00 Very Low Very Low Very Low
rheumatoid arthritis 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Bordatella Infection 1 100.00 Very High Very High Very High
INFLAMMATION 23 99.44 Very High Very High Very High
Pressure And Volume Under Development 2 86.92 High High
Renal Insufficiency 9 76.40 Quite High
Hearing Impairment 7 73.24 Quite High
Deafness 77 70.48 Quite High
Fabry Disease 32 66.80 Quite High
Lysosome Storage Disease 1 66.16 Quite High
Renal Disease 4 63.80 Quite High
Pain 2 62.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Phospholipase A2 isolated from Formosan cobra venom was shown to be a potent inhibitor of the binding with a 50% inhibition concentration of 26 nM.
Negative_regulation (inhibitor) of Phospholipase
1) Confidence 0.14 Published 1983 Journal Eur. J. Pharmacol. Section Abstract Doc Link 6301856 Disease Relevance 0 Pain Relevance 0.19
The atrazine-induced beta-hexosaminidase release was characterized by various inhibitors including antisense-oligodeoxynucleotide for Galpha(q/11), pertussis toxin, phospholipase C inhibitor U-73122, inositol 1,4,5-triphosphate receptor inhibitor xestospongin C and Ca(2+) channel blocker lanthanum chloride.
Negative_regulation (inhibitors) of phospholipase associated with bordatella infection
2) Confidence 0.04 Published 2006 Journal Toxicol. Sci. Section Abstract Doc Link 16381660 Disease Relevance 0.16 Pain Relevance 0.10
Synthesis and evaluation of benzophenone oximes derivatized with sydnone as inhibitors of secretory phospholipase A2 with anti-inflammatory activity.
Negative_regulation (inhibitors) of phospholipase associated with inflammation
3) Confidence 0.03 Published 2009 Journal Chem. Pharm. Bull. Section Title Doc Link 19122311 Disease Relevance 0.33 Pain Relevance 0.12
Aminoglycosides that resist to degradation can induce an alteration of the lysosomal phospholipase, a modified permeability of lysosomal membranes and a reduction in catabolism of renal proteins inducing phospholipidosis.
Negative_regulation (reduction) of phospholipase
4) Confidence 0.03 Published 2002 Journal BMC Med Genet Section Body Doc Link PMC134464 Disease Relevance 0.77 Pain Relevance 0
posttranslational processing, although a Ca2+-independent phospholipase inhibitor (bromoenol lactone) and a tyrosine kinase inhibitor (AG-126) are reported to inhibit ATP-induced IL-1?
Negative_regulation (inhibitor) of phospholipase
5) Confidence 0.02 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096759 Disease Relevance 0 Pain Relevance 0

General Comments

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