INT43161

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Context Info
Confidence 0.49
First Reported 1983
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.29
Pain Relevance 1.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

EOS (Homo sapiens)
Pain Link Frequency Relevance Heat
opioid receptor 4 99.30 Very High Very High Very High
antagonist 3 98.90 Very High Very High Very High
narcan 10 98.38 Very High Very High Very High
Pain 1 95.50 Very High Very High Very High
mu opioid receptor 1 95.44 Very High Very High Very High
Endogenous opioid 5 94.90 High High
opiate 2 92.24 High High
drug abuse 1 74.16 Quite High
Neurotransmitter 1 67.00 Quite High
Disease Link Frequency Relevance Heat
Bronchopulmonary Dysplasia 5 98.72 Very High Very High Very High
Syndrome 2 96.24 Very High Very High Very High
Pain 1 95.50 Very High Very High Very High
Injury 2 93.36 High High
Eating Disorder 1 92.72 High High
Aggression 1 91.28 High High
Unconsciousness 1 80.60 Quite High
Borderline Personality 2 75.00 Quite High
Drug Dependence 1 74.16 Quite High
Appetite Loss 1 72.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Anhedonia and feelings of emptiness may be an expression of reduced activity of the EOS.
Negative_regulation (reduced) of EOS
1) Confidence 0.49 Published 2010 Journal Psychol Rev Section Abstract Doc Link 20438240 Disease Relevance 1.03 Pain Relevance 0.45
This may be attributable to the use of doses insufficient to yield a complete EOS blockade.
Negative_regulation (blockade) of EOS
2) Confidence 0.32 Published 1983 Journal Arch. Gen. Psychiatry Section Abstract Doc Link 6303264 Disease Relevance 0 Pain Relevance 0.42
BACKGROUND: To evaluate the role of the endogenous opioid system (EOS) in abnormal pain perception in patients with syndrome X, we used a neuroendocrine approach, evaluating plasmatic luteinizing hormone (LH) changes after naloxone, a competitive antagonist of opioid receptors able to unblock tonic EOS inhibition on gonadotropin release.
Negative_regulation (inhibition) of EOS associated with pain, syndrome, antagonist, narcan, endogenous opioid and opioid receptor
3) Confidence 0.03 Published 1998 Journal Am. Heart J. Section Abstract Doc Link 9842013 Disease Relevance 0.27 Pain Relevance 0.51

General Comments

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