INT43212

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Context Info
Confidence 0.45
First Reported 1983
Last Reported 2007
Negated 0
Speculated 0
Reported most in Title
Documents 4
Total Number 4
Disease Relevance 0.24
Pain Relevance 2.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Adra2a) plasma membrane (Adra2a) cytoplasm (Adra2a)
signal transducer activity (Adra2a)
Anatomy Link Frequency
nucleus accumbens 2
brain 2
brainstem 1
hippocampus 1
Adra2a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Desipramine 8 100.00 Very High Very High Very High
medulla 6 100.00 Very High Very High Very High
Nucleus accumbens 4 99.84 Very High Very High Very High
Hippocampus 3 99.84 Very High Very High Very High
Morphine 8 99.82 Very High Very High Very High
antagonist 1 98.28 Very High Very High Very High
agonist 2 95.28 Very High Very High Very High
Opioid 3 95.16 Very High Very High Very High
Clonidine 11 94.92 High High
Eae 7 82.40 Quite High
Disease Link Frequency Relevance Heat
Opiate Addiction 2 81.44 Quite High
Urological Neuroanatomy 1 80.28 Quite High
Drug Dependence 1 79.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
[Effects of desipramine and clomipramine on alpha 2-adrenergic receptor function in nucleus accumbens: studies with intracerebral dialysis in freely moving rats].
Regulation ([Effects) of Gene_expression (function) of alpha 2-adrenergic in nucleus accumbens associated with nucleus accumbens and desipramine
1) Confidence 0.45 Published 1995 Journal Seishin Shinkeigaku Zasshi Section Title Doc Link 8532817 Disease Relevance 0 Pain Relevance 0.85
These results suggest that the amount of alpha-2 adrenoceptors can change rapidly while alpha-1 adrenoceptors are stable and that glucocorticoids are important in regulation of conformation of alpha-2 adrenoceptor through synthesis of certain protein(s).
Regulation (regulation) of Gene_expression (synthesis) of alpha-2 adrenoceptor
2) Confidence 0.27 Published 1983 Journal Life Sci. Section Abstract Doc Link 6306373 Disease Relevance 0 Pain Relevance 0.39
Effects of testosterone on alpha2A-adrenergic receptor expression in the rat brain.
Regulation (Effects) of Gene_expression (expression) of alpha2A-adrenergic in brain
3) Confidence 0.12 Published 2002 Journal Psychoneuroendocrinology Section Title Doc Link 11965356 Disease Relevance 0.08 Pain Relevance 0.29
Yohimbine prevents morphine-induced changes of glial fibrillary acidic protein in brainstem and alpha2-adrenoceptor gene expression in hippocampus.
Regulation (changes) of in brainstem Gene_expression (expression) of alpha2-adrenoceptor in hippocampus associated with medulla, hippocampus and morphine
4) Confidence 0.04 Published 2007 Journal Neurosci. Lett. Section Title Doc Link 17123717 Disease Relevance 0.16 Pain Relevance 0.94

General Comments

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