INT43224

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Context Info
Confidence 0.54
First Reported 1983
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 17
Total Number 17
Disease Relevance 3.69
Pain Relevance 6.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Adcyap1) signal transduction (Adcyap1) extracellular space (Adcyap1)
extracellular region (Adcyap1)
Anatomy Link Frequency
nerve 5
neuronal 1
medial 1
neurons 1
sympathetic 1
Adcyap1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 11 100.00 Very High Very High Very High
substance P 7 100.00 Very High Very High Very High
Enkephalin 5 100.00 Very High Very High Very High
qutenza 16 99.98 Very High Very High Very High
Dopamine 6 99.98 Very High Very High Very High
tetrodotoxin 1 99.98 Very High Very High Very High
antagonist 6 99.64 Very High Very High Very High
Endogenous opioid 2 98.84 Very High Very High Very High
dorsal root ganglion 9 98.16 Very High Very High Very High
Neuropeptide 36 98.10 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 16 98.16 Very High Very High Very High
Death 18 97.36 Very High Very High Very High
Injury 13 97.00 Very High Very High Very High
Cystitis 5 96.32 Very High Very High Very High
Nervous System Injury 3 90.40 High High
Disease 9 90.04 High High
Overactive Bladder 2 87.04 High High
Urological Neuroanatomy 7 81.28 Quite High
Neuropathic Pain 2 75.00 Quite High
Hirschsprung Disease 1 74.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pre-treatment of the rats with capsaicin caused a marked reduction of the PACAP-IR in the adrenal gland as well as in the superficial layers of the dorsal horn and caudal spinal trigeminal nucleus.
Negative_regulation (reduction) of PACAP-IR in adrenal gland associated with qutenza and dorsal horn
1) Confidence 0.54 Published 1996 Journal Brain Res. Section Abstract Doc Link 8738215 Disease Relevance 0.30 Pain Relevance 0.44
Neonatal capsaicin reduced the PACAP-38 concentration by approximately 50%, and accordingly a marked reduction in PACAP/CGRP-immunoreactive nerve fibres in the exocrine and endocrine pancreas was observed.
Negative_regulation (reduction) of PACAP in nerve associated with qutenza
2) Confidence 0.43 Published 2000 Journal Cell Tissue Res. Section Abstract Doc Link 10654070 Disease Relevance 0.08 Pain Relevance 0.13
Bilateral subdiaphragmatic vagotomy caused a slight but significant decrease in the PACAP-38 concentration compared with controls.
Negative_regulation (decrease) of PACAP-38
3) Confidence 0.43 Published 2000 Journal Cell Tissue Res. Section Abstract Doc Link 10654070 Disease Relevance 0.07 Pain Relevance 0.12
Neonatal capsaicin reduced the PACAP-38 concentration by approximately 50%, and accordingly a marked reduction in PACAP/CGRP-immunoreactive nerve fibres in the exocrine and endocrine pancreas was observed.
Negative_regulation (reduced) of PACAP-38 in nerve associated with qutenza
4) Confidence 0.43 Published 2000 Journal Cell Tissue Res. Section Abstract Doc Link 10654070 Disease Relevance 0.08 Pain Relevance 0.13
After neonatal capsaicin treatment the concentration of immunoreactive PACAP-38 as well as the number and intensity of PACAP-positive nerve fibres were reduced while vasoactive intestinal polypeptide immunoreactivity was unaffected.
Negative_regulation (reduced) of PACAP-38 in nerve associated with qutenza
5) Confidence 0.43 Published 1996 Journal Neuroscience Section Abstract Doc Link 8809823 Disease Relevance 0.31 Pain Relevance 0.17
The blocking effect of PACAP is not directly mediated by endogenous opioids because the antagonizing effect of Naloxone, an opioid receptor antagonist, was questionable.
Negative_regulation (blocking) of PACAP associated with antagonist, narcan, endogenous opioid and opioid receptor
6) Confidence 0.43 Published 1996 Journal Acta. Biol. Hung. Section Abstract Doc Link 9123995 Disease Relevance 0 Pain Relevance 0.24
Bladder afferent cells (40-45%) in the dorsal root ganglia (DRG; L1, L2, L6, and S1) from control animals also exhibited PACAP immunoreactivity.
Negative_regulation (exhibited) of PACAP in dorsal root ganglia
7) Confidence 0.42 Published 2000 Journal J. Comp. Neurol. Section Abstract Doc Link 10754506 Disease Relevance 0.49 Pain Relevance 0.08
These findings, in conjunction with the apparent absence of PACAP-IR in spinal sympathetic preganglionic neurons, sympathetic postganglionic neurons, and dorsal motor nucleus of the vagus, raise the possibility that PACAP-IR fibers observed in the adrenal medulla are primarily sensory in origin.
Negative_regulation (absence) of PACAP-IR in sympathetic associated with medulla
8) Confidence 0.40 Published 1996 Journal Brain Res. Section Abstract Doc Link 8738215 Disease Relevance 0.27 Pain Relevance 0.44
On the transected side the densities of both PACAP and calcitonin gene-related peptide-immunoreactive nerve fibres were reduced in the medial part.
Negative_regulation (reduced) of PACAP in medial associated with calcitonin gene-related peptide
9) Confidence 0.40 Published 1996 Journal Neuroscience Section Abstract Doc Link 8895878 Disease Relevance 0.17 Pain Relevance 0.56
In the present study it was demonstrated that PACAP, administered i.c.v. before the critical period of the proestrous stage, blocked the ovulation and prevented the proestrous LH surge in rats.
Negative_regulation (blocked) of PACAP
10) Confidence 0.37 Published 1996 Journal Acta. Biol. Hung. Section Abstract Doc Link 9123995 Disease Relevance 0 Pain Relevance 0.22
Extrinsic denervation caused a total loss of NPY/TH-, SP/CGRP- and SP/CGRP/VIP/NOS/PACAP-containing nerve fibres.
Negative_regulation (loss) of PACAP in nerve associated with calcitonin gene-related peptide and substance p
11) Confidence 0.35 Published 2002 Journal Auton Neurosci Section Abstract Doc Link 12132647 Disease Relevance 0 Pain Relevance 0.89
NT-3 infusion resulted in a limited reduction in the incidence and level of neuronal PACAP in medium to large size, but not small size, DRG neurons.
Negative_regulation (reduction) of PACAP in neuronal associated with dorsal root ganglion
12) Confidence 0.34 Published 2006 Journal Neuroscience Section Abstract Doc Link 16843605 Disease Relevance 1.11 Pain Relevance 0.84
All classical dopaminergic antagonists blocked dopamine inhibition of pituitary adenylate cyclase, pimozide (KI 1 nM) and spiperone (KI 0.8 nM) being the more potent.
Negative_regulation (inhibition) of pituitary adenylate cyclase in pituitary associated with dopamine and antagonist
13) Confidence 0.18 Published 1983 Journal Mol. Pharmacol. Section Abstract Doc Link 6306429 Disease Relevance 0 Pain Relevance 0.85
was reduced in PACAP-treated NPCs.
Negative_regulation (reduced) of PACAP
14) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2885411 Disease Relevance 0.10 Pain Relevance 0.12
Tetrodotoxin blocked the negative chronotropic and inotropic responses to PACAP-27 in isolated atria.
Negative_regulation (blocked) of PACAP associated with tetrodotoxin
15) Confidence 0.14 Published 1998 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9671107 Disease Relevance 0 Pain Relevance 0.18
These findings, in conjunction with the apparent absence of PACAP-IR in spinal sympathetic preganglionic neurons, sympathetic postganglionic neurons, and dorsal motor nucleus of the vagus, raise the possibility that PACAP-IR fibers observed in the adrenal medulla are primarily sensory in origin.
Negative_regulation (absence) of PACAP-IR in neurons associated with medulla
16) Confidence 0.14 Published 1996 Journal Brain Res. Section Abstract Doc Link 8738215 Disease Relevance 0.27 Pain Relevance 0.44
An increased cholinergic and adrenergic innervation is registered in the aganglionic segment in spite of the lack of neuronal cell bodies: Neuropeptides like vasoactive intestinal peptide (VIP), pituitary adenylate cyclase-activating polypeptide (PACAP), gastrin-releasing peptide (GRP), calcitonin gene-related peptide (CGRP), substance P (SP), enkephalins and galanin immunoreactive nerve fibres are all reduced in number in the aganglionic segment.
Negative_regulation (reduced) of PACAP in nerve associated with neuropeptide, enkephalin, substance p and calcitonin gene-related peptide
17) Confidence 0.03 Published 1994 Journal Histol. Histopathol. Section Abstract Doc Link 7981507 Disease Relevance 0.45 Pain Relevance 0.34

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