INT43226

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.71
First Reported 1983
Last Reported 2011
Negated 2
Speculated 0
Reported most in Body
Documents 75
Total Number 75
Disease Relevance 30.53
Pain Relevance 21.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Hivep3) intracellular (Hivep3) DNA binding (Hivep3)
cytoplasm (Hivep3)
Anatomy Link Frequency
nervous tissues 5
trigeminal ganglion 5
hippocampus 3
hippocampal formation 2
brain 2
Hivep3 (Mus musculus)
Pain Link Frequency Relevance Heat
opiate 9 100.00 Very High Very High Very High
sodium channel 4 100.00 Very High Very High Very High
trigeminal ganglion 410 99.84 Very High Very High Very High
Neuropathic pain 738 99.76 Very High Very High Very High
agonist 10 99.64 Very High Very High Very High
Peripheral nervous system 41 99.56 Very High Very High Very High
Spinal cord 533 99.36 Very High Very High Very High
Spinal nerve ligature 533 99.28 Very High Very High Very High
Pain 298 99.28 Very High Very High Very High
Hippocampus 410 99.20 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ebola Virus Infection 220 100.00 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 121 99.96 Very High Very High Very High
Cold Sores 131 99.94 Very High Very High Very High
Neuropathic Pain 1189 99.76 Very High Very High Very High
Francisella Infection 4 99.48 Very High Very High Very High
Ganglion Cysts 496 99.42 Very High Very High Very High
Nociception 42 99.36 Very High Very High Very High
Pain 297 99.28 Very High Very High Very High
Sprains And Strains 312 99.22 Very High Very High Very High
Immunization 204 98.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
While most of the recombinant AGAP was expressed in the form of insoluble inclusion body.
Gene_expression (expressed) of recombinant AGAP in body
1) Confidence 0.71 Published 2003 Journal Protein Expr. Purif. Section Abstract Doc Link 12597884 Disease Relevance 0 Pain Relevance 0.25
It has been shown, that vaccine strain of tularemia microbe, F.T.ISE., which produced recombinant beta-endorphin, when administered to CBA mice.
Gene_expression (produced) of recombinant beta-endorphin associated with sprains and strains and francisella infection
2) Confidence 0.66 Published 1993 Journal Biull Eksp Biol Med Section Abstract Doc Link 8274686 Disease Relevance 0.44 Pain Relevance 0.09
The observed correlated in time with the pattern of the dynamics of culture in the experimental animals and were associated with the level of recombinant beta-endorphin synthesis.
Gene_expression (synthesis) of recombinant beta-endorphin
3) Confidence 0.66 Published 1993 Journal Biull Eksp Biol Med Section Abstract Doc Link 8274686 Disease Relevance 0.41 Pain Relevance 0.09
The expression pattern of ZAS3 in the nervous system prompted us to investigate whether ZAS3 plays a role in neuropathic pain, a pathological condition in which pain is evoked at much lower stimulus thresholds and often with greater severity.
Gene_expression (expression) of ZAS3 in nervous system associated with pain and neuropathic pain
4) Confidence 0.62 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1361774 Disease Relevance 0.72 Pain Relevance 0.88
The ability of AbN but not AbC to react with astrocytes suggests that astrocytes may produce a ZAS3 isoform that does not contain the ZASC domain.


Gene_expression (produce) of ZAS3 in astrocytes
5) Confidence 0.62 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1361774 Disease Relevance 0 Pain Relevance 0.34
ZAS3 expression in trigeminal ganglion
Gene_expression (expression) of ZAS3 in trigeminal ganglion associated with ganglion cysts and trigeminal ganglion
6) Confidence 0.62 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1361774 Disease Relevance 0.57 Pain Relevance 0.40
The difference in gel mobility, immunogenicity, and cytoplasmic or nuclear distribution of ZAS3 isoforms suggest that the regulation of ZAS3 expression is complex and is different between brain and DRG.


Gene_expression (expression) of ZAS3 in brain
7) Confidence 0.62 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1361774 Disease Relevance 0.67 Pain Relevance 0.62
The various species reacting with the ZAS3 antibodies suggest that ZAS3 isoforms were produced in a tissue-specific manner.
Gene_expression (produced) of ZAS3
8) Confidence 0.62 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1361774 Disease Relevance 0.05 Pain Relevance 0.05
ZAS3-immunoreactivity (IR) was readily observed in the trigeminal ganglion, in agreement with abundant ZAS3 transcripts present in this tissue [24].
Gene_expression (present) of ZAS3 in trigeminal ganglion associated with ganglion cysts and trigeminal ganglion
9) Confidence 0.62 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1361774 Disease Relevance 0.57 Pain Relevance 0.38
Additionally, ZAS3 expression is found in astrocytes in brain and spinal cord.
Gene_expression (expression) of ZAS3 in brain associated with spinal cord
10) Confidence 0.62 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1361774 Disease Relevance 0.68 Pain Relevance 0.66
The expression of ZAS3 transcripts in the hippocampus of mouse embryos had not been seen in previous studies because para-sagittal sections were used for in situ hybridization [22,24] Neuronal cell bodies, including the pyramidal cells of the hippocampus proper Ammon's horn fields CA1, CA2 and CA3, and granule cells of the dentate gyrus, appeared as dark granules at low magnifications when stained with cresyl violet (Figure 2A).
Gene_expression (expression) of ZAS3 in hippocampus associated with pyramidal cell and hippocampus
11) Confidence 0.62 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1361774 Disease Relevance 0.26 Pain Relevance 0.36
We show for the first time that the expression of ZAS3 and its related genes, ZAS1 and ZAS2, is decreased in the ipsilateral versus contralateral L6 DRG seven days after SpNL (Figure 8).
Gene_expression (expression) of ZAS3
12) Confidence 0.62 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1361774 Disease Relevance 0.67 Pain Relevance 0.80
The alternative splicing of intron 10 will lead to the production of ZAS3 protein isoforms that lack the ZASN domain, whereas alternative splicing of exon 13 will lead to premature translation termination and production of carboxyl-truncated proteins that lack the ZASC domain [30].
Gene_expression (production) of ZAS3
13) Confidence 0.62 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1361774 Disease Relevance 0 Pain Relevance 0
RNA studies have shown that ZAS3 transcripts are expressed specifically in the lymphoid and nervous systems [22-24] Characterization of ZAS deficient mice suggests that ZAS2 and ZAS3 are involved in lymphoid development.
Gene_expression (expressed) of ZAS3 in nervous systems
14) Confidence 0.62 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1361774 Disease Relevance 0.33 Pain Relevance 0.22
The overall expression of ZAS3 was low in the lumbar spinal cord, where a more intense signal was observed in the grey matter than the white matter (Figure 4).
Gene_expression (expression) of ZAS3 in white matter associated with spinal cord
15) Confidence 0.62 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1361774 Disease Relevance 0 Pain Relevance 0.33
In this report, we further show the effect of L5 and L6 spinal nerve ligation (SpNL), a neuropathic pain model, on the expression of ZAS3 and NF-?
Gene_expression (expression) of ZAS3 in spinal nerve associated with spinal nerve ligature and neuropathic pain
16) Confidence 0.62 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1361774 Disease Relevance 0.39 Pain Relevance 0.66
The smaller 160 kDa ZAS3 was present in both cytoplasmic and nuclear extracts, whereas the 190 kDa ZAS3 was observed only in the nuclear extracts (Figure 6A, lanes 2 and 3).
Gene_expression (present) of ZAS3
17) Confidence 0.62 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1361774 Disease Relevance 0 Pain Relevance 0.03
Production of ZAS3 protein isoforms
Gene_expression (Production) of ZAS3
18) Confidence 0.62 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1361774 Disease Relevance 0 Pain Relevance 0.06
Immunoblot analyses using the ZAS3 antisera, antibodies against NF-?
Gene_expression (antisera) of ZAS3
19) Confidence 0.53 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1361774 Disease Relevance 0 Pain Relevance 0.04
The distribution of ZAS3 proteins in the rat nervous tissues was first determined by immunohistochemical procedures using ZAS3-specific antisera, AbN and AbC.
Gene_expression (antisera) of ZAS3-specific in nervous tissues
20) Confidence 0.53 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1361774 Disease Relevance 0.45 Pain Relevance 0.39

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox