INT43259

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Context Info
Confidence 0.43
First Reported 1983
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 2.70
Pain Relevance 3.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
macrophages 1
endothelial cells 1
neocortex 1
FAIM3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 5 100.00 Very High Very High Very High
narcan 5 99.84 Very High Very High Very High
orphanin 19 99.76 Very High Very High Very High
agonist 6 98.80 Very High Very High Very High
opiate 6 98.00 Very High Very High Very High
Kinase C 6 97.38 Very High Very High Very High
Immobilon 5 96.48 Very High Very High Very High
Opioid 6 94.20 High High
Serotonin 2 92.56 High High
Neurotransmitter 2 91.84 High High
Disease Link Frequency Relevance Heat
Epilepsy 7 95.96 Very High Very High Very High
Gastric Motility Disorder 1 95.68 Very High Very High Very High
Increased Venous Pressure Under Development 4 95.40 Very High Very High Very High
Coronary Artery Disease 8 94.08 High High
Atherosclerosis 6 90.52 High High
Sclerosis 3 81.68 Quite High
Cancer 1 79.04 Quite High
Stress 2 69.84 Quite High
Neuroblastoma 2 66.72 Quite High
Hyperlipidemia 2 64.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We have then attempted to block selectively the mu receptor by administering a small dose of naloxone.
Negative_regulation (block) of mu receptor associated with narcan
1) Confidence 0.43 Published 1983 Journal J. Nucl. Med. Section Abstract Doc Link 6308189 Disease Relevance 0.10 Pain Relevance 1.02
However, DAMGO-induced mu receptor phosphorylation and OFQ/N-induced mu receptor desensitization occurred in cells expressing mu receptors lacking non-GRK phosphorylation sites.
Negative_regulation (desensitization) of mu receptor
2) Confidence 0.33 Published 2005 Journal Mol. Pharmacol. Section Abstract Doc Link 15890842 Disease Relevance 0.07 Pain Relevance 0.41
These data suggest that OFQ/N binds to NOP receptors and activates protein kinase C, which then increases the ability of GRK2 to phosphorylate the agonist-occupied mu receptor, heterologously regulating homologous mu receptor desensitization.
Negative_regulation (desensitization) of mu receptor associated with kinase c and agonist
3) Confidence 0.29 Published 2005 Journal Mol. Pharmacol. Section Abstract Doc Link 15890842 Disease Relevance 0.05 Pain Relevance 0.40
Naltrexone is more potent in blocking mu receptor activity than kappa receptor activity.
Negative_regulation (blocking) of mu receptor
4) Confidence 0.22 Published 1993 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7679737 Disease Relevance 0 Pain Relevance 0.36
The aim of this work was to evaluate the level of G-proteins activation mediated by DAMGO (a mu receptor selective peptide) and nociceptin, and the binding to mu and nociceptin (NOP) receptors and adenylyl cyclase (AC) in neocortex of patients with pharmacoresistant temporal lobe epilepsy.
Negative_regulation (peptide) of mu receptor in neocortex associated with epilepsy and orphanin
5) Confidence 0.06 Published 2009 Journal Neurobiol. Dis. Section Abstract Doc Link 19573600 Disease Relevance 0.76 Pain Relevance 0.47
There also is evidence that both macrophages and endothelial cells can regulate NO production through a specific mu 3 morphine receptor, an effect that can be blocked by naloxone.
Negative_regulation (blocked) of mu 3 morphine receptor in endothelial cells associated with narcan and morphine
6) Confidence 0.01 Published 1996 Journal Adv. Neuroimmunol. Section Abstract Doc Link 8876769 Disease Relevance 0.86 Pain Relevance 0.38
There also is evidence that both macrophages and endothelial cells can regulate NO production through a specific mu 3 morphine receptor, an effect that can be blocked by naloxone.
Negative_regulation (blocked) of mu 3 morphine receptor in macrophages associated with narcan and morphine
7) Confidence 0.00 Published 1996 Journal Adv. Neuroimmunol. Section Abstract Doc Link 8876769 Disease Relevance 0.86 Pain Relevance 0.38

General Comments

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