INT43327

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Context Info
Confidence 0.46
First Reported 1983
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.54
Pain Relevance 1.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (ADRA2A) small molecule metabolic process (ADRA2A) plasma membrane (ADRA2A)
cytoplasm (ADRA2A) signal transducer activity (ADRA2A)
Anatomy Link Frequency
PGE1 1
nucleus 1
motoneurons 1
ADRA2A (Homo sapiens)
Pain Link Frequency Relevance Heat
depression 2 99.92 Very High Very High Very High
Locus ceruleus 2 99.84 Very High Very High Very High
Clonidine 53 99.62 Very High Very High Very High
adenocard 1 97.44 Very High Very High Very High
gABA 1 95.08 Very High Very High Very High
antidepressant 4 92.12 High High
Desipramine 1 88.00 High High
agonist 1 85.68 High High
monoamine 2 75.00 Quite High
Descending facilitatory control 1 72.56 Quite High
Disease Link Frequency Relevance Heat
Depression 2 99.92 Very High Very High Very High
Volume Depletion And Dehydration 1 90.36 High High
Sleep Disorders 5 89.36 High High
Diarrhoea 1 88.96 High High
Vomiting 1 88.44 High High
Poisoning 20 83.28 Quite High
Hypotension 20 83.24 Quite High
Death 5 83.12 Quite High
Unconsciousness 1 79.28 Quite High
Affective Disorder 2 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results suggest that an autoinhibitory action may be induced by alpha2-receptor activation of locus coeruleus neurons in humans, and that this device may serve as a mechanism for a myotonolytic action on spinal motoneurons.
Positive_regulation (activation) of alpha2-receptor in motoneurons associated with locus ceruleus
1) Confidence 0.46 Published 1999 Journal Neuroreport Section Abstract Doc Link 10363929 Disease Relevance 0.09 Pain Relevance 0.35
The sedative effects of clonidine are attributed to activation of the alpha-2-adrenergic receptor in the locus coeruleus which suppresses the spontaneous firing rate of the nucleus and increases the activity of GABA[23].
Positive_regulation (activation) of alpha-2-adrenergic in nucleus associated with gaba, locus ceruleus and clonidine
2) Confidence 0.07 Published 2009 Journal Trials Section Body Doc Link PMC2743678 Disease Relevance 1.14 Pain Relevance 0.59
Platelet alpha 2-adrenergic receptor number as measured by tritiated dihydroergocriptine (3H-DHE) binding is increased in depressed patients compared to controls, while cyclic 3'-5' adenosine monophosphate (cAMP) production in response to prostaglandin E1 (PGE1) and norepinephrine (NE) inhibition of PGE1-stimulated cAMP production are reduced in the platelets of depressed patients.
Positive_regulation (increased) of Platelet alpha 2-adrenergic in PGE1 associated with adenocard
3) Confidence 0.04 Published 1983 Journal Prog. Neuropsychopharmacol. Biol. Psychiatry Section Abstract Doc Link 6310694 Disease Relevance 0.32 Pain Relevance 0.59

General Comments

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