INT43356

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Context Info
Confidence 0.59
First Reported 1983
Last Reported 2010
Negated 2
Speculated 1
Reported most in Abstract
Documents 13
Total Number 14
Disease Relevance 8.27
Pain Relevance 3.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (GDF15) extracellular space (GDF15) extracellular region (GDF15)
cell-cell signaling (GDF15)
Anatomy Link Frequency
colon 2
blood 1
GDF15 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 74 100.00 Very High Very High Very High
aspirin 19 99.82 Very High Very High Very High
Inflammation 10 98.76 Very High Very High Very High
cytokine 15 97.68 Very High Very High Very High
Kinase C 4 75.00 Quite High
COX-2 inhibitor 5 62.80 Quite High
Pain 2 41.48 Quite Low
antagonist 4 10.40 Low Low
tetrodotoxin 1 5.00 Very Low Very Low Very Low
transdermal 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 21 100.00 Very High Very High Very High
Colon Cancer 30 99.84 Very High Very High Very High
Apoptosis 119 99.82 Very High Very High Very High
Cancer 50 98.76 Very High Very High Very High
Recurrence 1 93.48 High High
Metastasis 8 86.64 High High
Prostate Cancer 2 84.32 Quite High
Death 12 83.76 Quite High
Disease 6 78.64 Quite High
Reprotox - General 1 6 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The regulation of NAG-1 is complex, but these agents act through either p53 or EGR-1 related pathways.
Regulation (regulation) of NAG-1
1) Confidence 0.59 Published 2006 Journal J. Biochem. Mol. Biol. Section Abstract Doc Link 17129398 Disease Relevance 0.92 Pain Relevance 0.13
Current use of acetylsalicylic acid did not influence serum MIC-1 levels in this cohort.
Neg (not) Regulation (influence) of serum MIC-1 associated with aspirin
2) Confidence 0.54 Published 2007 Journal Cancer Epidemiol. Biomarkers Prev. Section Abstract Doc Link 17372249 Disease Relevance 0.90 Pain Relevance 0.09
Two MPI–V2 probes were mounted within MIC1–IONlr chambers, where the vasoactive substances were inserted for iontophoretic administration in the same area as that where the blood flow was being recorded.
Regulation (mounted) of MIC1 in blood
3) Confidence 0.44 Published 2008 Journal Microvasc Res Section Body Doc Link PMC2666799 Disease Relevance 0 Pain Relevance 0
A novel peroxisome proliferator-activated receptor gamma ligand, MCC-555, induces apoptosis via posttranscriptional regulation of NAG-1 in colorectal cancer cells.
Regulation (regulation) of NAG-1 associated with colon cancer, apoptosis and cytokine
4) Confidence 0.37 Published 2006 Journal Mol. Cancer Ther. Section Title Doc Link 16731769 Disease Relevance 0.81 Pain Relevance 0.18
MCC-555 was found to affect NAG-1 mRNA stability.
Regulation (affect) of NAG-1 mRNA
5) Confidence 0.37 Published 2006 Journal Mol. Cancer Ther. Section Abstract Doc Link 16731769 Disease Relevance 0.76 Pain Relevance 0.09
One such gene is NAG-1 (NSAID-Activated Gene), a critical gene regulated by a number of COX inhibitors and chemopreventive chemicals.
Regulation (regulated) of NAG-1 associated with cinod
6) Confidence 0.25 Published 2006 Journal Prog. Lipid Res. Section Abstract Doc Link 16337272 Disease Relevance 0.74 Pain Relevance 0.58
The induction of apoptosis in cells of human colon cancer cell lines after gamma irradiation was investigated to determine whether apoptosis was mediated by TP53 and the subsequent expression of its downstream target, the NSAID-activated gene (NAG1).
Regulation (target) of NAG1 in colon associated with colon cancer, cinod and apoptosis
7) Confidence 0.25 Published 2006 Journal Radiat. Res. Section Abstract Doc Link 16435911 Disease Relevance 0.68 Pain Relevance 0.17
The induction of apoptosis in cells of human colon cancer cell lines after gamma irradiation was investigated to determine whether apoptosis was mediated by TP53 and the subsequent expression of its downstream target, the NSAID-activated gene (NAG1).
Regulation (target) of NSAID-activated gene in colon associated with colon cancer, cinod and apoptosis
8) Confidence 0.22 Published 2006 Journal Radiat. Res. Section Abstract Doc Link 16435911 Disease Relevance 0.68 Pain Relevance 0.17
NAG-1 (nonsteroidal anti-inflammatory drug-activated gene), a member of the transforming growth factor beta superfamily, is involved in cellular processes such as inflammation, apoptosis/survival, and tumorigenesis and is regulated by p53, Sp1, and Egr-1.
Regulation (involved) of NAG-1 associated with inflammation, cinod and apoptosis
9) Confidence 0.20 Published 2005 Journal J. Biol. Chem. Section Abstract Doc Link 15757899 Disease Relevance 0.46 Pain Relevance 0.25
Our results indicate that NAG-1 is a potential molecular target of AST in its antitumorigenic and proapoptotic actions, which would have additive effects when used along with PI3K-Akt inhibitors.
Regulation (target) of NAG-1
10) Confidence 0.19 Published 2009 Journal Int. J. Cancer Section Abstract Doc Link 19384947 Disease Relevance 0.32 Pain Relevance 0.13
In the present study we explored other pathways of apoptosis induction and, in particular, investigated the role of the so-called NSAID-activated gene, NAG-1, which belongs to the TGF-?
Spec (investigated) Regulation (role) of NAG-1 associated with cinod and apoptosis
11) Confidence 0.13 Published 2007 Journal J Transl Med Section Body Doc Link PMC2174440 Disease Relevance 0.78 Pain Relevance 0.54
Several studies have shown that the anti-tumorigenic and pro-apoptotic role of NAG-1 protein [11,15,16] is regulated by several NSAIDs, such as aspirin, indomethacin and ibuprofen, providing new clues to explain the anti-cancer activities of these anti-inflammatory agents.
Regulation (regulated) of NAG-1 protein associated with aspirin, inflammation, cancer, cinod and apoptosis
12) Confidence 0.11 Published 2007 Journal J Transl Med Section Body Doc Link PMC2174440 Disease Relevance 0.96 Pain Relevance 0.50
These results are the first to show partitioning of sulindac and metabolites to human breast tissue and the first evidence for a potential dose-dependent effect of sulindac on growth differentiation factor 15 levels in NAF.
Regulation (effect) of factor 15
13) Confidence 0.08 Published 2010 Journal Cancer Prev Res (Phila) Section Abstract Doc Link 20051377 Disease Relevance 0.18 Pain Relevance 0.17
In contrast to the other NSAID tested, piroxicam, a member of a new class of NSAID, the oxicams, did not affect mitochondrial or microsomal 45Ca transport at concentrations up to 300 microM, while the ID50 for inhibition of PGE synthesis was 0.35 microM.
Neg (not) Regulation (affect) of NSAID associated with cinod
14) Confidence 0.02 Published 1983 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 6312024 Disease Relevance 0.07 Pain Relevance 0.61

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