INT4336

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Context Info
Confidence 0.58
First Reported 1975
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 13
Disease Relevance 7.22
Pain Relevance 1.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (REN) extracellular space (REN) extracellular region (REN)
intracellular (REN) response to stress (REN)
Anatomy Link Frequency
plasma 4
sympathetic 2
juxtaglomerular apparatus 2
blood 1
REN (Homo sapiens)
Pain Link Frequency Relevance Heat
Clonidine 14 99.42 Very High Very High Very High
noradrenaline 3 92.60 High High
tolerance 4 86.72 High High
alcohol 9 86.40 High High
Calcium channel 26 72.80 Quite High
anesthesia 2 71.48 Quite High
agonist 1 65.68 Quite High
imagery 4 46.40 Quite Low
antagonist 44 34.72 Quite Low
beta blocker 7 21.44 Low Low
Disease Link Frequency Relevance Heat
Pressure Volume 2 Under Development 16 99.88 Very High Very High Very High
Pre-eclampsia 33 99.74 Very High Very High Very High
Proteinuria 7 99.64 Very High Very High Very High
Hypertension 143 99.24 Very High Very High Very High
Renal Artery Obstruction 11 99.20 Very High Very High Very High
Hyponatremia 27 97.66 Very High Very High Very High
Cirrhosis 45 97.12 Very High Very High Very High
Pressure And Volume Under Development 79 95.56 Very High Very High Very High
Bradycardia 2 94.64 High High
Pheochromocytoma 6 94.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cortisol and aldosterone excess suppresses renin production through negative feedback.
Negative_regulation (suppresses) of Gene_expression (production) of renin
1) Confidence 0.58 Published 2010 Journal J Gen Intern Med Section Body Doc Link PMC2811596 Disease Relevance 0.39 Pain Relevance 0
Renal denervation reduced renin secretion and prevented the suppression of renin secretion produced by intravenous clonidine.
Negative_regulation (suppression) of Gene_expression (produced) of renin associated with clonidine
2) Confidence 0.43 Published 1975 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1120965 Disease Relevance 0.58 Pain Relevance 0.71
We conclude that in our hypertensive patients with renal artery stenosis, clonidine lowered blood pressure by a reduction in central sympathetic activity independently of renin suppression.
Negative_regulation (reduction) of Gene_expression (suppression) of renin in sympathetic associated with renal artery obstruction, pressure volume 2 under development, hypertension and clonidine
3) Confidence 0.42 Published 1988 Journal J Hypertens Suppl Section Abstract Doc Link 3071592 Disease Relevance 0.72 Pain Relevance 0.45
(4) What is the role of ANP as a therapeutic mod<<span style="background-c</span>o</span>lor:#B0E0E6">/span>ality in surgical patients?
Negative_regulation (role) of Gene_expression (system) of renin in blood
4) Confidence 0.41 Published 1989 Journal J Cardiothorac Anesth Section Abstract Doc Link 2535291 Disease Relevance 0.17 Pain Relevance 0.07
There is large evidence from animal and human studies that inhibition of the renin–angiotensin system reduces proteinuria.35,36
Negative_regulation (inhibition) of Gene_expression (system) of renin associated with proteinuria
5) Confidence 0.36 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2788599 Disease Relevance 1.24 Pain Relevance 0
Acute worsening of chronic hyponatremia may have various etiologic factors, including: generalized haemodynamic derangement with low peripheral resistance, reduced effective arterial volume, hypothalamic overproduction of antidiuretic hormone, elevated renin and angiotensin, hypotonic fluid ingestion and reduced glomerular filtration, all of which may lead to marked water retention [5,7,8].
Negative_regulation (reduced) of Gene_expression (overproduction) of renin associated with hyponatremia and pressure and volume under development
6) Confidence 0.28 Published 2010 Journal Cases J Section Body Doc Link PMC2851673 Disease Relevance 1.39 Pain Relevance 0.04
We did not measure the activity of vasopressor systems in our study, but decreased levels of renin and aldosterone have been reported in patients with Child–Pugh grade C cirrhosis after plasma expansion [16].
Negative_regulation (decreased) of Gene_expression (levels) of renin in plasma associated with cirrhosis
7) Confidence 0.27 Published 2008 Journal Crit Care Section Body Doc Link PMC2374626 Disease Relevance 0.46 Pain Relevance 0.03
Blockade of the renin-angiotensin system plus calcium entry blockade or diuretic therapy
Negative_regulation (Blockade) of Gene_expression (system) of renin
8) Confidence 0.18 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2672450 Disease Relevance 0.20 Pain Relevance 0
Blockade of the renin-angiotensin system plus calcium entry blockade or diuretic therapy
Negative_regulation (blockade) of Gene_expression (system) of renin
9) Confidence 0.18 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2672450 Disease Relevance 0.20 Pain Relevance 0
Animal experiments implicate 1,25-dihydroxyvitamin D in inhibiting renin expression in the juxtaglomerular apparatus and blocks proliferation of vascular smooth muscle cells (VSMC), which could influence systemic blood pressure [76-79].
Negative_regulation (inhibiting) of Gene_expression (expression) of renin in juxtaglomerular apparatus
10) Confidence 0.17 Published 2010 Journal Nutr J Section Body Doc Link PMC3019131 Disease Relevance 0.39 Pain Relevance 0
In preeclampsia PRA, plasma renin concentration and plasma Ang II are reduced compared to normal pregnancy[52].
Negative_regulation (reduced) of Gene_expression (concentration) of renin in plasma associated with pre-eclampsia
11) Confidence 0.16 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2739214 Disease Relevance 0.59 Pain Relevance 0.03
According to the renin hypothesis, those patients receiving an additional anti-renin-system drug—such as an angiotensin converting enzyme inhibitor, an angiotensin receptor blocker, or a ?
Negative_regulation (receiving) of Gene_expression (hypothesis) of renin
12) Confidence 0.05 Published 2010 Journal BMJ : British Medical Journal Section Body Doc Link PMC2811239 Disease Relevance 0.25 Pain Relevance 0.04
Blockers of the renin-angiotensin system, ?
Negative_regulation (Blockers) of Gene_expression (system) of renin-angiotensin
13) Confidence 0.03 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2663449 Disease Relevance 0.65 Pain Relevance 0.04

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