INT43387

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Context Info
Confidence 0.15
First Reported 1983
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.40
Pain Relevance 0.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (S100A6) signal transduction (S100A6) nuclear envelope (S100A6)
plasma membrane (S100A6) nucleus (S100A6) cytoplasm (S100A6)
Anatomy Link Frequency
plasma 1
S100A6 (Homo sapiens)
Pain Link Frequency Relevance Heat
opiate 3 100.00 Very High Very High Very High
opioid receptor 2 75.04 Quite High
antagonist 1 73.76 Quite High
narcan 2 72.88 Quite High
Catecholamine 3 69.28 Quite High
Opioid 3 51.44 Quite High
ischemia 12 24.56 Low Low
cINOD 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Dopamine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 1 81.08 Quite High
Sepsis 44 79.76 Quite High
Chronic Renal Failure 1 71.88 Quite High
Infection 3 50.48 Quite High
Pneumonia 1 49.28 Quite Low
Hyperemia 8 29.68 Quite Low
Cv Unclassified Under Development 11 24.56 Low Low
INFLAMMATION 4 5.00 Very Low Very Low Very Low
Pressure Volume 2 Under Development 4 5.00 Very Low Very Low Very Low
Adhesions 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This study was designed to investigate the effect of dermorphin (D), a new synthetic potent opiate-like peptide (H-Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH2), on PRA, plasma aldosterone (PA), plasma cortisol (PC), and plasma ACTH levels in normal men.
Spec (investigate) Regulation (effect) of PRA in plasma associated with opiate
1) Confidence 0.15 Published 1983 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 6313731 Disease Relevance 0 Pain Relevance 0.37
We compared values of PRA and Ang II to assess consistency within an intact biologic system and found a strong correlation between these mediators (Spearman r = 0.75; P < 0.0001; see Figure 2).
Regulation (values) of PRA
2) Confidence 0.11 Published 2010 Journal Crit Care Section Body Doc Link PMC2875539 Disease Relevance 0.40 Pain Relevance 0.03
Indomethacin as well as meloxicam had no significant effect on basal PRA but inhibited the furosemide-stimulated PRA increase.
Neg (no) Regulation (effect) of PRA
3) Confidence 0.07 Published 1998 Journal J. Investig. Med. Section Body Doc Link 9737091 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.

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