INT4340

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Context Info
Confidence 0.70
First Reported 1975
Last Reported 2010
Negated 4
Speculated 1
Reported most in Abstract
Documents 46
Total Number 47
Disease Relevance 14.52
Pain Relevance 15.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ldha) mitochondrion (Ldha) oxidoreductase activity (Ldha)
cytoplasm (Ldha)
Anatomy Link Frequency
hearts 8
microglia 6
neurons 4
myocardium 2
hepatocytes 2
Ldha (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 612 100.00 Very High Very High Very High
cocaine 54 99.98 Very High Very High Very High
aspirin 22 99.98 Very High Very High Very High
dexamethasone 8 99.92 Very High Very High Very High
Paracetamol 73 99.84 Very High Very High Very High
Enkephalin 9 99.82 Very High Very High Very High
Potency 78 99.50 Very High Very High Very High
Taxol 12 99.24 Very High Very High Very High
Morphine 39 99.20 Very High Very High Very High
local anesthetic 14 99.14 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 78 100.00 Very High Very High Very High
Blister 8 99.88 Very High Very High Very High
Apoptosis 343 99.80 Very High Very High Very High
Death 320 99.72 Very High Very High Very High
Diabetes Mellitus 312 99.68 Very High Very High Very High
Targeted Disruption 119 99.32 Very High Very High Very High
Toxicity 72 99.14 Very High Very High Very High
Injury 109 98.48 Very High Very High Very High
Obesity 4 94.56 High High
Drug Induced Neurotoxicity 21 82.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These toxins also significantly increased LDH and/or gamma-GT release in HepG2 spheroids.
Positive_regulation (increased) of Localization (release) of LDH
1) Confidence 0.70 Published 2003 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 12781628 Disease Relevance 0.07 Pain Relevance 0.20
Ca++ antagonists, nonselective for slow Ca++ channels (flunarizine, cinnarizine, lidoflazine, prenylamine and bepridil) inhibited veratridine-induced release of LDH with IC50 values between 0.11 and 0.47 microM.
Positive_regulation (induced) of Localization (release) of LDH associated with antagonist
2) Confidence 0.70 Published 1990 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2175795 Disease Relevance 0.08 Pain Relevance 0.39
Ca++ antagonists selective for slow Ca++ channels were less potent and inhibited veratridine-induced release of LDH at concentrations in the following order of potency: nicardipine greater than gallopamil and verapamil greater than niludipine greater than nitrendipine greater than nifedipine greater than nimodipine greater than diltiazem.
Positive_regulation (induced) of Localization (release) of LDH associated with antagonist and potency
3) Confidence 0.70 Published 1990 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2175795 Disease Relevance 0.08 Pain Relevance 0.41
Tested local anesthetics were incomplete inhibitors of veratridine-induced release of LDH.
Positive_regulation (induced) of Localization (release) of LDH associated with local anesthetic
4) Confidence 0.70 Published 1990 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2175795 Disease Relevance 0.14 Pain Relevance 0.49
H2O2 (600 microM) increased the left ventricular end-diastolic pressure, decreased the tissue level of ATP, and increased the release of lactate dehydrogenase from the myocardium.
Positive_regulation (increased) of Localization (release) of lactate dehydrogenase in myocardium
5) Confidence 0.70 Published 1999 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10422783 Disease Relevance 0 Pain Relevance 0.08
Veratridine-induced LDH release can be inhibited by 100 microM riluzole (-90% and by tetrodotoxin (1 microM).
Positive_regulation (induced) of Localization (release) of LDH associated with tetrodotoxin
6) Confidence 0.68 Published 1994 Journal Neurosci. Lett. Section Abstract Doc Link 7824190 Disease Relevance 0.31 Pain Relevance 0.18
At the start of the experiment aspirin increased the urinary excretion of lactate dehydrogenase (LDH) while phenacetin raised the excretion of all four enzymes studies (acid phosphatase, alkaline phosphatase, glutamate dehydrogenase (GDH), LDH indicating generalised cellular injury.
Positive_regulation (increased) of Localization (excretion) of lactate dehydrogenase associated with aspirin, glutamate and injury
7) Confidence 0.64 Published 1975 Journal Chem. Biol. Interact. Section Abstract Doc Link 1122562 Disease Relevance 0.09 Pain Relevance 0.32
Buprenorphine pretreatment significantly attenuated cocaine-induced release of LDH.
Positive_regulation (induced) of Localization (release) of LDH associated with cocaine and buprenorphine
8) Confidence 0.63 Published 1991 Journal Life Sci. Section Abstract Doc Link 1745104 Disease Relevance 0.31 Pain Relevance 1.12
Volatile anesthetics also significantly attenuated LDH release during reperfusion.
Positive_regulation (attenuated) of Localization (release) of LDH
9) Confidence 0.50 Published 1996 Journal Acta Anaesthesiol Scand Section Body Doc Link 8986190 Disease Relevance 0.11 Pain Relevance 0
One hundred and twenty to 240 min of deprivation caused graded increases in glutamate overflow, LDH release and 45Ca influx.
Positive_regulation (increases) of Localization (release) of LDH associated with glutamate
10) Confidence 0.50 Published 1997 Journal Neuropharmacology Section Abstract Doc Link 9294967 Disease Relevance 0.26 Pain Relevance 0.34
Reperfusion caused a transient reduction in lactate production and a significant increase in LDH release.
Positive_regulation (increase) of Localization (release) of LDH
11) Confidence 0.47 Published 1996 Journal Acta Anaesthesiol Scand Section Body Doc Link 8986190 Disease Relevance 0.13 Pain Relevance 0
A good correlation was found between the potency of the drugs to inhibit released LDH induced by 30 microM veratridine in neuronal cultures and their binding affinity for the batrachotoxin binding site of Na+ channels in rat cortex synaptosomal preparation.
Positive_regulation (induced) of Localization (released) of LDH in cortex associated with potency
12) Confidence 0.47 Published 1990 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2175795 Disease Relevance 0.14 Pain Relevance 0.48
By comparison, acetaminophen, at equivalently lethal concentrations (4 or 16 mM) did not cause marginal blebs, but resulted in a similar time course of LDH release and trypan blue uptake.
Neg (not) Positive_regulation (resulted) of Localization (release) of LDH associated with paracetamol and blister
13) Confidence 0.46 Published 1985 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 3927521 Disease Relevance 0.76 Pain Relevance 0.17
At the start of the experiment aspirin increased the urinary excretion of lactate dehydrogenase (LDH) while phenacetin raised the excretion of all four enzymes studies (acid phosphatase, alkaline phosphatase, glutamate dehydrogenase (GDH), LDH indicating generalised cellular injury.
Positive_regulation (increased) of Localization (excretion) of LDH associated with aspirin, glutamate and injury
14) Confidence 0.46 Published 1975 Journal Chem. Biol. Interact. Section Abstract Doc Link 1122562 Disease Relevance 0.09 Pain Relevance 0.32
Indeed, a previous study on isolated coronary ligated hearts from normal rats has shown that the rate of release of lactate dehydrogenase (LDH) during the first 90 min of ischaemia can be enhanced by replacing glucose (11 mM) in the perfusion fluid with either albumin-bound palmitate (0.9 mM) or sodium DL-3-hydroxybutyrate (10 mM) as the sole energy substrate [11].
Positive_regulation (enhanced) of Localization (release) of lactate dehydrogenase in hearts associated with cv unclassified under development
15) Confidence 0.46 Published 1986 Journal J. Mol. Cell. Cardiol. Section Abstract Doc Link 3746923 Disease Relevance 0.17 Pain Relevance 0.06
Indeed, a previous study on isolated coronary ligated hearts from normal rats has shown that the rate of release of lactate dehydrogenase (LDH) during the first 90 min of ischaemia can be enhanced by replacing glucose (11 mM) in the perfusion fluid with either albumin-bound palmitate (0.9 mM) or sodium DL-3-hydroxybutyrate (10 mM) as the sole energy substrate [11].
Positive_regulation (enhanced) of Localization (release) of LDH in hearts associated with cv unclassified under development
16) Confidence 0.46 Published 1986 Journal J. Mol. Cell. Cardiol. Section Abstract Doc Link 3746923 Disease Relevance 0.17 Pain Relevance 0.06
It was concluded that the cytotoxicity was detected earlier by measuring WST-1 than by measuring LDH release because the reduction of mitochondrial respiration is an expressions of earlier toxicity for cellular function, while the measured increase in the LDH release occurs after the failure of the cell membrane.
Positive_regulation (measuring) of Localization (release) of LDH associated with toxicity
17) Confidence 0.42 Published 2005 Journal J Toxicol Sci Section Abstract Doc Link 15800402 Disease Relevance 0.46 Pain Relevance 0.17
Mitcheva et al. [31] reported that CCl4 injection leads to a significant increase in LDH leakage from rat hepatocytes.
Positive_regulation (increase) of Localization (leakage) of LDH in hepatocytes
18) Confidence 0.41 Published 2010 Journal Scientia Pharmaceutica Section Body Doc Link PMC3007612 Disease Relevance 0.16 Pain Relevance 0
For all time points observed, the two highest doses of Coc (1 x 10(-3) and 1 x 10(-5) M) significantly depressed contractility and induced significant LDH release.
Positive_regulation (induced) of Localization (release) of LDH associated with cocaine
19) Confidence 0.40 Published 1992 Journal Toxicology Section Abstract Doc Link 1566279 Disease Relevance 0.21 Pain Relevance 0.50
It was concluded that the cytotoxicity was detected earlier by measuring WST-1 than by measuring LDH release because the reduction of mitochondrial respiration is an expressions of earlier toxicity for cellular function, while the measured increase in the LDH release occurs after the failure of the cell membrane.
Positive_regulation (increase) of Localization (release) of LDH associated with toxicity
20) Confidence 0.39 Published 2005 Journal J Toxicol Sci Section Abstract Doc Link 15800402 Disease Relevance 0.46 Pain Relevance 0.16

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