INT43407

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Context Info
Confidence 0.16
First Reported 1983
Last Reported 2003
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.98
Pain Relevance 2.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
medulla 1
pons 1
P9Ehs1 (Mus musculus)
Pain Link Frequency Relevance Heat
opiate 6 100.00 Very High Very High Very High
Glutamate 3 99.80 Very High Very High Very High
Enkephalin 2 99.76 Very High Very High Very High
medulla 6 99.64 Very High Very High Very High
MU agonist 2 98.90 Very High Very High Very High
Opioid 2 97.60 Very High Very High Very High
antinociception 6 97.32 Very High Very High Very High
tail-flick 2 92.72 High High
Glutamate receptor 2 92.32 High High
agonist 6 91.52 High High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 30 97.82 Very High Very High Very High
Hyperglycemia 4 89.16 High High
Pain 2 82.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present study was designed to investigate in streptozotocin-induced diabetic mice the effect of the selective micro-opioid agonist [D-Ala(2), NMePhe(4), Gly-ol(5)]enkephalin (DAMGO) on G-protein activation by monitoring guanosine-5'-O-(3-[35S]thio)triphosphate ([35S]GTPgammaS) binding to pons/medulla membranes, which contain the key areas for opioid antinociception.
G-protein Binding (binding) of in medulla associated with antinociception, medulla, mu agonist, diabetes mellitus, enkephalin and opioid
1) Confidence 0.16 Published 2000 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10915837 Disease Relevance 0.99 Pain Relevance 0.94
Cyclic AMP-mediated regulation of striatal glutamate release: interactions of presynaptic ligand- and voltage-gated ion channels and G-protein-coupled receptors.
G-protein Binding (interactions) of associated with glutamate
2) Confidence 0.07 Published 2003 Journal Neurochem. Int. Section Title Doc Link 12742088 Disease Relevance 0 Pain Relevance 0.30
The present study was designed to investigate in streptozotocin-induced diabetic mice the effect of the selective micro-opioid agonist [D-Ala(2), NMePhe(4), Gly-ol(5)]enkephalin (DAMGO) on G-protein activation by monitoring guanosine-5'-O-(3-[35S]thio)triphosphate ([35S]GTPgammaS) binding to pons/medulla membranes, which contain the key areas for opioid antinociception.
G-protein Binding (binding) of in pons associated with antinociception, medulla, mu agonist, diabetes mellitus, enkephalin and opioid
3) Confidence 0.05 Published 2000 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10915837 Disease Relevance 0.99 Pain Relevance 0.94
In the presence of ethanol, opiate receptor affinity is altered, and this alteration is modified by GTP, suggesting that ethanol influences the interaction of the opiate receptor complex with the G-protein.
G-protein Binding (interaction) of associated with opiate
4) Confidence 0.04 Published 1983 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 6314380 Disease Relevance 0 Pain Relevance 0.71

General Comments

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