INT43415

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Context Info
Confidence 0.56
First Reported 1983
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 11
Total Number 17
Disease Relevance 7.65
Pain Relevance 5.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (CYP4A11) endoplasmic reticulum (CYP4A11)
Anatomy Link Frequency
smooth muscle cells 2
spinal cord neurons 2
cornea 1
CYP4A11 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 52 100.00 Very High Very High Very High
agonist 48 100.00 Very High Very High Very High
aspirin 71 99.84 Very High Very High Very High
cINOD 32 99.78 Very High Very High Very High
Calcium channel 5 98.68 Very High Very High Very High
Spinal cord 2 98.64 Very High Very High Very High
psoriasis 6 97.76 Very High Very High Very High
Inflammation 216 96.64 Very High Very High Very High
diclofenac 5 93.32 High High
potassium channel 4 74.28 Quite High
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 15 99.96 Very High Very High Very High
Renal Cell Carcinoma 6 98.16 Very High Very High Very High
Psoriasis 6 97.76 Very High Very High Very High
Nicotine Addiction 69 97.56 Very High Very High Very High
INFLAMMATION 228 97.04 Very High Very High Very High
Disease 46 97.00 Very High Very High Very High
Cancer 697 96.80 Very High Very High Very High
Age-related Macular Degeneration 6 95.64 Very High Very High Very High
Fatty Liver 63 95.20 Very High Very High Very High
Diabetic Retinopathy 6 94.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In primary spinal cord neurons, dipyrone selectively and dose-dependently increased 5(S)-(HETE) and 12(S)-HETE synthesis.
Gene_expression (synthesis) of HETE in spinal cord neurons associated with spinal cord
1) Confidence 0.56 Published 2009 Journal J. Proteome Res. Section Abstract Doc Link 19697962 Disease Relevance 0.21 Pain Relevance 0.23
In contrast to the extensive data on the role of rodent CYP4A gene in animal models of steatosis and steatohepatitis, little is known about how the human CYP4A11 gene is controlled by PPAR?
Gene_expression (gene) of CYP4A11
2) Confidence 0.41 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 0.59 Pain Relevance 0.09
In primary spinal cord neurons, dipyrone selectively and dose-dependently increased 5(S)-(HETE) and 12(S)-HETE synthesis.
Gene_expression (synthesis) of HETE in spinal cord neurons associated with spinal cord
3) Confidence 0.38 Published 2009 Journal J. Proteome Res. Section Abstract Doc Link 19697962 Disease Relevance 0.21 Pain Relevance 0.24
Expression of CYP1A2, CYP2C8, CYP2C18, CYP2C19, CYP2D6, CYP3A7, CYP4A11, FMO1, and FMO3 was below the limit of detection (LOD) in all investigated samples (data not shown).


Spec (investigated) Gene_expression (Expression) of CYP4A11
4) Confidence 0.21 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1665420 Disease Relevance 0.49 Pain Relevance 0
Two calcium channel blockers, verapamil and nifedipine, inhibited PGE2, iSRS and i12-HETE synthesis in a dose-dependent manner.
Gene_expression (synthesis) of HETE associated with calcium channel
5) Confidence 0.02 Published 1983 Journal Biochem. Pharmacol. Section Abstract Doc Link 6315014 Disease Relevance 0.21 Pain Relevance 0.24
Over the past decade, the Falck laboratory has synthesized agonists and antagonists of CYP 450 metabolites, including EETs and 20-HETE.
Gene_expression (synthesized) of 20-HETE associated with antagonist and agonist
6) Confidence 0.01 Published 2010 Journal Cancer Metastasis Rev Section Body Doc Link PMC2962793 Disease Relevance 0.14 Pain Relevance 0.10
FGF-2 increases arachidonic acid production, potentially stimulating CYP4A and production of 20-HETE [85].
Gene_expression (production) of 20-HETE
7) Confidence 0.01 Published 2010 Journal Cancer Metastasis Rev Section Body Doc Link PMC2962793 Disease Relevance 0.48 Pain Relevance 0.21
However, these studies did not determine whether 20-HETE was produced by the cornea or endothelial cells and, therefore, further studies are needed [90].
Gene_expression (produced) of 20-HETE in cornea
8) Confidence 0.01 Published 2010 Journal Cancer Metastasis Rev Section Body Doc Link PMC2962793 Disease Relevance 1.20 Pain Relevance 0.14
The overexpression of CYP4A1, which increases 20-HETE production, results in increased neovessel formation [88].
Gene_expression (production) of 20-HETE
9) Confidence 0.01 Published 2010 Journal Cancer Metastasis Rev Section Body Doc Link PMC2962793 Disease Relevance 0.49 Pain Relevance 0.23
In the systemic circulation, 20-HETE produced by vascular smooth muscle cells acts as a vasoconstrictor [4].
Gene_expression (produced) of 20-HETE in smooth muscle cells
10) Confidence 0.01 Published 2010 Journal Cancer Metastasis Rev Section Body Doc Link PMC2962793 Disease Relevance 1.26 Pain Relevance 0.13
This cell type expressed CYP4F isoforms and produced 20-HETE [94].
Gene_expression (produced) of 20-HETE
11) Confidence 0.01 Published 2010 Journal Cancer Metastasis Rev Section Body Doc Link PMC2962793 Disease Relevance 1.17 Pain Relevance 0.08
The 12-LO product, 12(S)-HETE, produces vasodilatation by activating BKCa channels and thus hyperpolarizing the vascular smooth muscle cells, whereas HEETA and THETA, generated by 15-LO, open SKCa-like channels [30•].
Gene_expression (produces) of HETE in smooth muscle cells associated with increased venous pressure under development
12) Confidence 0.01 Published 2010 Journal Curr Hypertens Rep Section Body Doc Link PMC2910890 Disease Relevance 0.39 Pain Relevance 0.04
Both the S516M mutant and ASA-acetylated form of PGHS-2 (ASA-PGHS-2) synthesize 15(R)-HETE and have apparent K(m) values for arachidonic acid within 10-fold of the apparent K(m) value for untreated PGHS-2.
Gene_expression (synthesize) of HETE associated with aspirin
13) Confidence 0.00 Published 1997 Journal Mol. Pharmacol. Section Abstract Doc Link 9016346 Disease Relevance 0.14 Pain Relevance 0.60
The time courses of turnover-dependent inactivation were similar for reactions catalyzed by PGHS-2 and ASA-PGHS-2, whereas the PGHS-2(S516M) showed a decrease in both the initial rate of 15-HETE production and rate of enzyme inactivation.
Gene_expression (production) of HETE associated with aspirin
14) Confidence 0.00 Published 1997 Journal Mol. Pharmacol. Section Abstract Doc Link 9016346 Disease Relevance 0.16 Pain Relevance 0.86
These results demonstrate that the sensitivity to inhibition by NSAIDs of the 15-HETE production by ASA-treated PGHS-2 is different than that of prostaglandin production by PGHS-2 and that Ser516 plays an important role in the interaction with fenamate inhibitors.
Gene_expression (production) of HETE associated with aspirin and cinod
15) Confidence 0.00 Published 1997 Journal Mol. Pharmacol. Section Abstract Doc Link 9016346 Disease Relevance 0.16 Pain Relevance 0.93
The production of 15-HETE by modified PGHS-2 was sensitive to inhibition by most nonsteroidal anti-inflammatory drugs (NSAIDs), including selective PGHS-2 inhibitors.
Gene_expression (production) of HETE associated with inflammation and cinod
16) Confidence 0.00 Published 1997 Journal Mol. Pharmacol. Section Abstract Doc Link 9016346 Disease Relevance 0.17 Pain Relevance 0.88
As observed for the cyclooxygenase activity of PGHS-2, the inhibition of 15-HETE production by indomethacin was time-dependent for both ASA-PGHS-2 and PGHS-2(S516M).
Gene_expression (production) of HETE associated with aspirin
17) Confidence 0.00 Published 1997 Journal Mol. Pharmacol. Section Abstract Doc Link 9016346 Disease Relevance 0.17 Pain Relevance 0.94

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