INT4342

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Context Info
Confidence 0.69
First Reported 1975
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 27
Total Number 29
Disease Relevance 15.19
Pain Relevance 5.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (ALPP)
Anatomy Link Frequency
osteoblasts 4
blood 2
MG-63 2
placenta 2
hepatocyte 1
ALPP (Homo sapiens)
Pain Link Frequency Relevance Heat
aspirin 16 99.92 Very High Very High Very High
MU agonist 12 99.92 Very High Very High Very High
Glutamate 1 99.92 Very High Very High Very High
visual analogue scale 5 99.72 Very High Very High Very High
backache 7 99.62 Very High Very High Very High
metalloproteinase 16 99.36 Very High Very High Very High
opioid receptor 12 98.46 Very High Very High Very High
narcan 6 98.28 Very High Very High Very High
cINOD 17 94.00 High High
Analgesic 4 92.64 High High
Disease Link Frequency Relevance Heat
Pressure And Volume Under Development 26 100.00 Very High Very High Very High
Calcification 1 100.00 Very High Very High Very High
Hypercalcemia 31 99.92 Very High Very High Very High
Sprains And Strains 25 99.92 Very High Very High Very High
Nicotine Addiction 56 99.68 Very High Very High Very High
Bone Disease 3 99.66 Very High Very High Very High
Low Back Pain 8 99.62 Very High Very High Very High
Papillomavirus Infection 123 99.00 Very High Very High Very High
Cancer 228 98.92 Very High Very High Very High
Osteoporosis 138 98.74 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both indomethacin and aspirin inhibited the secretion of alkaline phosphatase and the uptake of [3H]thymidine by osteoblasts in a dose-dependent fashion at therapeutic concentrations.
Localization (secretion) of alkaline phosphatase in osteoblasts associated with aspirin
1) Confidence 0.69 Published 1988 Journal Br. J. Rheumatol. Section Abstract Doc Link 3044473 Disease Relevance 0.09 Pain Relevance 0.43
The effect of indomethacin and aspirin on alkaline phosphatase secretion and [3H]thymidine incorporation by human osteoblasts.
Localization (secretion) of alkaline phosphatase in osteoblasts associated with aspirin
2) Confidence 0.69 Published 1988 Journal Br. J. Rheumatol. Section Title Doc Link 3044473 Disease Relevance 0.09 Pain Relevance 0.48
He was treated with oral alendronate at 5 mg per day, which led to the disappearance of his low back pain (VAS = 0) and the normalization of his T-ALP and uNTX levels within six months [9].
Localization (normalization) of T-ALP associated with low back pain, visual analogue scale and backache
3) Confidence 0.63 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2887900 Disease Relevance 0.75 Pain Relevance 0.49
Her dermal fibroblasts in culture synthesized unremarkable levels of ALP with proper membrane topography and lipid anchoring; ALP released into the medium also appeared normal.
Localization (released) of ALP in fibroblasts
4) Confidence 0.62 Published 1996 Journal J. Bone Miner. Res. Section Abstract Doc Link 8770706 Disease Relevance 0.86 Pain Relevance 0.14
We have therefore thought it of interest to study the presence of opioid receptors in the human osteoblast-like cell line MG-63, and to evaluate the effects of different opioid agonists on the secretion of alkaline phosphatase and osteocalcin by these cells.
Localization (secretion) of alkaline phosphatase in MG-63 associated with mu agonist, osteoporosis and opioid receptor
5) Confidence 0.57 Published 2000 Journal Neuroendocrinology Section Abstract Doc Link 11025413 Disease Relevance 0.62 Pain Relevance 0.78
None of the opioid agonists modified the secretion of alkaline phosphatase.
Localization (secretion) of alkaline phosphatase associated with mu agonist
6) Confidence 0.57 Published 2000 Journal Neuroendocrinology Section Abstract Doc Link 11025413 Disease Relevance 0.38 Pain Relevance 1.12
Expression of opioid receptors in osteoblast-like MG-63 cells, and effects of different opioid agonists on alkaline phosphatase and osteocalcin secretion by these cells.
Localization (secretion) of alkaline phosphatase in MG-63 associated with mu agonist, osteoporosis and opioid receptor
7) Confidence 0.57 Published 2000 Journal Neuroendocrinology Section Title Doc Link 11025413 Disease Relevance 0.62 Pain Relevance 0.47
Optimal osteogenic differentiation in both cell types, as determined by alkaline phosphatase cytochemistry, secretion of osteocalcin, mineral (calcium phosphate) deposition and scanning electron microscopy, was obtained with the same three-dimensional culture.
Localization (secretion) of alkaline phosphatase
8) Confidence 0.52 Published 2004 Journal Cells Tissues Organs (Print) Section Abstract Doc Link 15550755 Disease Relevance 0.33 Pain Relevance 0.08
0.05) prognostic factors for overall survival were age at diagnosis, FIGO stage, grade of tumor, histology (mixed mesodermal, clear cell and endometrioid versus serous papillary), the presence or absence of ascites, albumin, ALP, PS, and debulking of the tumor [81].
Localization (presence) of ALP associated with pressure and volume under development and cancer
9) Confidence 0.48 Published 2010 Journal Nutr J Section Body Doc Link PMC3019132 Disease Relevance 1.51 Pain Relevance 0
circulating protein is mostly PLAP released by the placenta.
Localization (released) of PLAP in placenta
10) Confidence 0.48 Published 2006 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC1559920 Disease Relevance 0.51 Pain Relevance 0
levels of PLAP/PLAP-like were observed in 2 patients with
Localization (observed) of PLAP
11) Confidence 0.44 Published 2006 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC1559920 Disease Relevance 1.13 Pain Relevance 0.09
that serum PLAP/PLAP-like was more sensitive (56%) than other
Localization (serum) of PLAP
12) Confidence 0.44 Published 2006 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC1559920 Disease Relevance 0.65 Pain Relevance 0
correspond to PLAP activity in placenta, while PLAP in serum of
Localization (serum) of PLAP in placenta
13) Confidence 0.44 Published 2006 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC1559920 Disease Relevance 0.39 Pain Relevance 0
The tumor cells were negative for CD34, CK20, alpha-fetoprotein, placental-like alkaline phosphatase, hepatocyte paraffin 1, polyclonal carcinoembryonic antigen, CD10, CA-125, prostate-specific antigen, and prostatic acid phosphatase.
Localization (like) of alkaline phosphatase in hepatocyte associated with cancer
14) Confidence 0.17 Published 2010 Journal Diagn. Cytopathol. Section Abstract Doc Link 19813270 Disease Relevance 0.94 Pain Relevance 0.08
The release of ALP and ACE as biomarkers of epithelial and endothelial integrity are not elevated during the perfusion and do not correspond to the small translocation of 192Ir after a lag-time of about 60 min -UFP.
Localization (release) of ALP
15) Confidence 0.17 Published 2005 Journal Part Fibre Toxicol Section Body Doc Link PMC1180470 Disease Relevance 0.12 Pain Relevance 0.03
P. tunicata strain D2 secretes an autotoxic 190 kDa dimeric protein referred to as AlpP.
Localization (secretes) of AlpP associated with sprains and strains
16) Confidence 0.15 Published 2007 Journal Marine Drugs Section Body Doc Link PMC2365693 Disease Relevance 0.65 Pain Relevance 0
Data showed that CS and GS affected neither basal nor vitamin D3-induced alkaline phosphatase or osteocalcin release.
Localization (release) of alkaline phosphatase
17) Confidence 0.15 Published 2007 Journal Arthritis Res Ther Section Abstract Doc Link PMC2246236 Disease Relevance 0.55 Pain Relevance 0.25
rpm for 20 minutes, and blood sera were then collected and stored at 4°C prior immediate determination of glutamic oxaloacetic acid transaminase (GOT), glutamic pyruvic acid transaminase (GPT), alkaline phosphatase (ALP), acid phosphatase (ACP), total protein, total albumin, creatinine, urea, and uric acid.
Spec (determination) Localization (determination) of alkaline phosphatase in blood
18) Confidence 0.14 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2864892 Disease Relevance 0 Pain Relevance 0
rpm for 20 minutes, and blood sera were then collected and stored at 4°C prior immediate determination of glutamic oxaloacetic acid transaminase (GOT), glutamic pyruvic acid transaminase (GPT), alkaline phosphatase (ALP), acid phosphatase (ACP), total protein, total albumin, creatinine, urea, and uric acid.
Spec (determination) Localization (determination) of ALP in blood
19) Confidence 0.14 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2864892 Disease Relevance 0 Pain Relevance 0
The effect of these drugs or of the addition of LTB(4) on alkaline phosphatase (AP) activity and osteocalcin release by OA and normal osteoblasts was determined.
Localization (release) of alkaline phosphatase in osteoblasts
20) Confidence 0.13 Published 2002 Journal Arthritis Rheum. Section Body Doc Link 12124864 Disease Relevance 0.08 Pain Relevance 0

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