INT4344

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Context Info
Confidence 0.19
First Reported 1975
Last Reported 1997
Negated 1
Speculated 0
Reported most in Abstract
Documents 2
Total Number 4
Disease Relevance 1.83
Pain Relevance 0.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (MTAP) small molecule metabolic process (MTAP) nucleus (MTAP)
cellular nitrogen compound metabolic process (MTAP) cytoplasm (MTAP)
Anatomy Link Frequency
liver 1
hepatocytes 1
MTAP (Homo sapiens)
Pain Link Frequency Relevance Heat
adenocard 6 99.02 Very High Very High Very High
Paracetamol 6 99.00 Very High Very High Very High
Angina 1 70.32 Quite High
Disease Link Frequency Relevance Heat
Myocardial Infarction 4 98.92 Very High Very High Very High
Injury 6 97.88 Very High Very High Very High
Hepatotoxicity 12 95.72 Very High Very High Very High
Death 9 93.52 High High
Infarction 1 92.24 High High
Cv General 3 Under Development 1 70.32 Quite High
Cv Unclassified Under Development 1 68.96 Quite High
Heart Rate Under Development 1 66.32 Quite High
Liver Cancer 3 59.36 Quite High
Necrosis 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, no glycogen phosphorylase activity was detected in the serum of healthy persons.
Positive_regulation (detected) of phosphorylase
1) Confidence 0.19 Published 1975 Journal Clin. Chim. Acta Section Abstract Doc Link 1122638 Disease Relevance 0.56 Pain Relevance 0.07
The status of cytosolic Ca2+ was determined by measuring Ca2+-dependent activation of glycogen phosphorylase a.
Positive_regulation (activation) of phosphorylase
2) Confidence 0.05 Published 1997 Journal Hepatology Section Abstract Doc Link 9185764 Disease Relevance 0.40 Pain Relevance 0.18
Primary cultures of mouse hepatocytes exposed to a toxic concentration of APAP showed twofold and greater increases in glycogen phosphorylase a stimulation at 6 hours, which was reversible with Ca2+-chelating agents.
Positive_regulation (increases) of phosphorylase in hepatocytes
3) Confidence 0.04 Published 1997 Journal Hepatology Section Abstract Doc Link 9185764 Disease Relevance 0.46 Pain Relevance 0.18
Calcium-dependent DNA damage and adenosine 3',5'-cyclic monophosphate-independent glycogen phosphorylase activation in an in vitro model of acetaminophen-induced liver injury.
Neg (independent) Positive_regulation (activation) of phosphorylase in liver associated with paracetamol, adenocard and injury
4) Confidence 0.04 Published 1997 Journal Hepatology Section Title Doc Link 9185764 Disease Relevance 0.41 Pain Relevance 0.25

General Comments

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