INT43441

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Context Info
Confidence 0.24
First Reported 1981
Last Reported 2003
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 0.46
Pain Relevance 7.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein targeting (Hps4) cytoplasmic membrane-bounded vesicle (Hps4) lysosome (Hps4)
cytoplasm (Hps4)
Anatomy Link Frequency
nucleus accumbens 1
spinal cord 1
neurons 1
Hps4 (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 61 100.00 Very High Very High Very High
opioid receptor 28 100.00 Very High Very High Very High
Nucleus accumbens 10 99.08 Very High Very High Very High
mu opioid receptor 17 98.88 Very High Very High Very High
Spinal cord 7 98.88 Very High Very High Very High
Analgesic 2 98.58 Very High Very High Very High
Morphine 2 97.84 Very High Very High Very High
Kappa opioid receptor 1 97.76 Very High Very High Very High
opiate 7 96.04 Very High Very High Very High
unmyelinated 3 94.96 High High
Disease Link Frequency Relevance Heat
Bradycardia 3 86.36 High High
Increased Venous Pressure Under Development 2 81.20 Quite High
Heart Rate Under Development 5 80.96 Quite High
Ganglion Cysts 1 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Computerized curve fitting of displacement curves performed at three different concentrations of 3H-DADLE indicated that a one site competitive model was sufficient to explain the interactions of leu-enkephalin (LE) and D-ser2-thr6-leucine enkephalin with 3H-DADLE binding.
LE Binding (interactions) of associated with enkephalin
1) Confidence 0.24 Published 1983 Journal Life Sci. Section Abstract Doc Link 6316063 Disease Relevance 0 Pain Relevance 0.62
Computerized curve fitting of displacement curves performed at three different concentrations of 3H-DADLE indicated that a one site competitive model was sufficient to explain the interactions of leu-enkephalin (LE) and D-ser2-thr6-leucine enkephalin with 3H-DADLE binding.
LE Binding (binding) of associated with enkephalin
2) Confidence 0.24 Published 1983 Journal Life Sci. Section Abstract Doc Link 6316063 Disease Relevance 0 Pain Relevance 0.63
The results indicate the presence of LE in explants of fetal mouse spinal cord with attached DRGs and offer an in vitro model system in which the onset and development of peptidergic neurons can be studied as they form functional cellular interrelationships with neurons bearing opioid and monoaminergic receptors in these organotypic cultures.
LE Binding (presence) of in neurons associated with enkephalin, opioid, monoamine and spinal cord
3) Confidence 0.17 Published 1981 Journal Peptides Section Abstract Doc Link 7267405 Disease Relevance 0.16 Pain Relevance 0.76
Collectively, these observations support the hypothesis that the local nodal sympatholytic effect of LE was mediated by kappa-opioid receptors that reduced the effective interstitial concentration of norepinephrine and not the result of a postjunctional interaction between LE and norepinephrine.
LE Binding (interaction) of associated with kappa opioid receptor and enkephalin
4) Confidence 0.05 Published 2003 Journal Exp. Biol. Med. (Maywood) Section Abstract Doc Link 12968061 Disease Relevance 0.30 Pain Relevance 0.86
Ultrastructural immunocytochemical localization of mu-opioid receptors in rat nucleus accumbens: extrasynaptic plasmalemmal distribution and association with Leu5-enkephalin.
LE Binding (association) of in nucleus accumbens associated with nucleus accumbens, mu opioid receptor and enkephalin
5) Confidence 0.01 Published 1996 Journal J. Neurosci. Section Title Doc Link 8753878 Disease Relevance 0 Pain Relevance 1.42
Observed sites for potential axonal associations with LE included coexistence of MOR and LE within the same terminal, as well as close appositions between differentially labeled axons.
LE Binding (associations) of associated with opioid receptor and enkephalin
6) Confidence 0.01 Published 1996 Journal J. Neurosci. Section Abstract Doc Link 8753878 Disease Relevance 0 Pain Relevance 1.67
To establish the cellular sites for the spinally mediated analgesic effects of MOR activation and the potential anatomical substrates for interactions with LE, we examined the ultrastructural localization of MOR and LE immunoreactivities in the adult rat cervical spinal cord (C3-C5).
LE Binding (interactions) of in spinal cord associated with analgesic, mu opioid receptor, enkephalin and spinal cord
7) Confidence 0.01 Published 1996 Journal Brain Res. Section Abstract Doc Link 8883864 Disease Relevance 0 Pain Relevance 1.48

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