INT43443

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Context Info
Confidence 0.19
First Reported 1983
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 2.90
Pain Relevance 2.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
neuronal 1
bridge 1
H3 (Mus musculus)
Pain Link Frequency Relevance Heat
anticonvulsant 2 99.60 Very High Very High Very High
Opioid 3 99.04 Very High Very High Very High
Migraine 3 98.24 Very High Very High Very High
Catecholamine 3 97.04 Very High Very High Very High
Potency 1 96.52 Very High Very High Very High
antagonist 4 96.16 Very High Very High Very High
Morphine 2 93.36 High High
agonist 12 92.76 High High
Inflammatory response 1 92.00 High High
Enkephalin 12 91.08 High High
Disease Link Frequency Relevance Heat
Cold Sores 89 99.76 Very High Very High Very High
Infection 11 99.48 Very High Very High Very High
Cancer 116 98.36 Very High Very High Very High
Headache 7 98.24 Very High Very High Very High
Cervical Cancer 10 97.40 Very High Very High Very High
Ganglion Cysts 70 84.32 Quite High
Breast Cancer 6 81.68 Quite High
Targeted Disruption 20 78.84 Quite High
Herpes Simplex Virus 1 73.96 Quite High
Sprains And Strains 45 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
BACKGROUND: Subcutaneous histamine at low concentrations interacts with H3-receptors and may constitute a new therapeutic drug in migraine prophylaxis.
H3 Binding (interacts) of associated with migraine
1) Confidence 0.19 Published 2008 Journal Gac Med Mex Section Abstract Doc Link 18942262 Disease Relevance 0.17 Pain Relevance 0.35
Normally, H3 acetylation is associated with the regulatory sequences in the promoters of actively transcribed genes.
H3 Binding (associated) of
2) Confidence 0.17 Published 2007 Journal Neural Develop Section Body Doc Link PMC1796875 Disease Relevance 0.50 Pain Relevance 0.18
In conclusion, both new and conventional H3-blockers interacted at the enteric neuronal sites here studied with a 1000-30,000 fold lower antagonistic potency than that previously reported for the ileal H3 histamine receptors.
H3 Binding (interacted) of in neuronal associated with potency
3) Confidence 0.13 Published 1999 Journal J Auton Pharmacol Section Abstract Doc Link 10385265 Disease Relevance 0 Pain Relevance 0.47
A two-site competitive model was required to adequately describe the interactions of these mu selective ligands with 3H-DADLE.
3H-DADLE Binding (interactions) of
4) Confidence 0.08 Published 1983 Journal Life Sci. Section Abstract Doc Link 6316063 Disease Relevance 0 Pain Relevance 0.60
These data indicate that: 1) putative mu and delta selective ligands do not bind to a common high affinity site; 2) mu selective ligands are not simple mixed inhibitors of a single site labeled by 3H-DADLE; and 3) competitive binding models may not explain the interaction of mu ligands with 3H-DADLE binding.
3H-DADLE Binding (binding) of
5) Confidence 0.08 Published 1983 Journal Life Sci. Section Abstract Doc Link 6316063 Disease Relevance 0 Pain Relevance 0.48
We recently demonstrated, within the context of a phase I study, that magnesium valproate when used at only slightly higher doses than those utilized as anticonvulsant, not only produces H3 and H4 histone hyperacetylation in PBMN cells, but also leads to hyperacetylation of H3 and H4 hyperacetylation and HDAC activity inhibition in primary tumors of patients with cervical cancer [104].
H3 Binding (hyperacetylation) of associated with cervical cancer, cancer and anticonvulsant
6) Confidence 0.06 Published 2006 Journal J Transl Med Section Body Doc Link PMC1413557 Disease Relevance 0.56 Pain Relevance 0.05
We recently demonstrated, within the context of a phase I study, that magnesium valproate when used at only slightly higher doses than those utilized as anticonvulsant, not only produces H3 and H4 histone hyperacetylation in PBMN cells, but also leads to hyperacetylation of H3 and H4 hyperacetylation and HDAC activity inhibition in primary tumors of patients with cervical cancer [104].
H3 Binding (hyperacetylation) of associated with cervical cancer, cancer and anticonvulsant
7) Confidence 0.05 Published 2006 Journal J Transl Med Section Body Doc Link PMC1413557 Disease Relevance 0.55 Pain Relevance 0.05
As Glu122 is in contact with the ring of retinal, this indicates an interaction of the ring with the H3/H5 network that is considerably altered in this precursor state of the mutant as compared to wildtype, and partly (? 
H3 Binding (interaction) of
8) Confidence 0.04 Published 2008 Journal J Mol Biol Section Body Doc Link PMC2726285 Disease Relevance 0 Pain Relevance 0
Recently, studies examining the viral genome during the primary HSV-1 infection in vitro have shown that H3 is associated with HSV-1 DNA in the initial stage of the infection, further suggesting that productive HSV-1 infections maintain covalent histone modifications that are typically representative of transcribed cellular genes [5], [13]–[17].
H3 Binding (associated) of associated with cold sores and infection
9) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2973973 Disease Relevance 1.13 Pain Relevance 0
The absence of the salt bridge between H3 and the PSB, which is linked to H7 by the side chain of Lys296, allows the H1/H2/H7 network to adopt its active state conformation already in this precursor state stabilized at ? 
H3 Neg (absence) Binding (absence) of in bridge
10) Confidence 0.03 Published 2008 Journal J Mol Biol Section Body Doc Link PMC2726285 Disease Relevance 0 Pain Relevance 0
opioid and the angiotensin AT1 receptors interhelical interactions between H3 and H7 are maintained between Asp and Tyr residues and two Asn residues, respectively, which also constrain the basal activity of these receptors.20–22
H3 Binding (interactions) of associated with opioid
11) Confidence 0.03 Published 2008 Journal J Mol Biol Section Body Doc Link PMC2726285 Disease Relevance 0 Pain Relevance 0.19

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