INT43447

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Context Info
Confidence 0.07
First Reported 1983
Last Reported 1983
Negated 1
Speculated 0
Reported most in Abstract
Documents 1
Total Number 3
Disease Relevance 0
Pain Relevance 1.82

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protein targeting (Hps4) cytoplasmic membrane-bounded vesicle (Hps4) lysosome (Hps4)
cytoplasm (Hps4)
H3 (Mus musculus)
Hps4 (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 18 100.00 Very High Very High Very High
Morphine 3 97.84 Very High Very High Very High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Computerized curve fitting of displacement curves performed at three different concentrations of 3H-DADLE indicated that a one site competitive model was sufficient to explain the interactions of leu-enkephalin (LE) and D-ser2-thr6-leucine enkephalin with 3H-DADLE binding.
3H-DADLE Binding (binding) of LE associated with enkephalin
1) Confidence 0.07 Published 1983 Journal Life Sci. Section Abstract Doc Link 6316063 Disease Relevance 0 Pain Relevance 0.63
Computerized curve fitting of displacement curves performed at three different concentrations of 3H-DADLE indicated that a one site competitive model was sufficient to explain the interactions of leu-enkephalin (LE) and D-ser2-thr6-leucine enkephalin with 3H-DADLE binding.
3H-DADLE Binding (interactions) of LE associated with enkephalin
2) Confidence 0.07 Published 1983 Journal Life Sci. Section Abstract Doc Link 6316063 Disease Relevance 0 Pain Relevance 0.63
However, this two site model did not correctly predict the interaction of LE with 3H-DADLE in the presence of morphiceptin.
3H-DADLE Neg (not) Binding (interaction) of LE associated with enkephalin
3) Confidence 0.05 Published 1983 Journal Life Sci. Section Abstract Doc Link 6316063 Disease Relevance 0 Pain Relevance 0.57

General Comments

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