INT4345

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Context Info
Confidence 0.67
First Reported 1975
Last Reported 2010
Negated 4
Speculated 13
Reported most in Abstract
Documents 157
Total Number 169
Disease Relevance 80.75
Pain Relevance 48.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

RNA binding (Gtf3a) nucleus (Gtf3a) intracellular (Gtf3a)
DNA binding (Gtf3a)
Anatomy Link Frequency
nerve 17
brain 9
neurons 9
lung 6
blood 5
Gtf3a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 397 100.00 Very High Very High Very High
Pain 216 100.00 Very High Very High Very High
cytokine 210 100.00 Very High Very High Very High
bDMF 175 100.00 Very High Very High Very High
Nerve growth factor 160 100.00 Very High Very High Very High
Neuropeptide 42 100.00 Very High Very High Very High
Enkephalin 38 100.00 Very High Very High Very High
Opioid 29 100.00 Very High Very High Very High
Intracerebroventricular 5 100.00 Very High Very High Very High
substance P 18 99.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 485 100.00 Very High Very High Very High
Cancer 351 100.00 Very High Very High Very High
Necrosis 128 100.00 Very High Very High Very High
Adhesions 53 100.00 Very High Very High Very High
Burns 9 100.00 Very High Very High Very High
Natriuresis 5 100.00 Very High Very High Very High
Primary Sclerosing Cholangitis 2 100.00 Very High Very High Very High
Hemorrhagic Shock 7 99.84 Very High Very High Very High
Nervous System Injury 81 99.82 Very High Very High Very High
Diabetes Mellitus 826 99.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present study, we prove by behavioral and electromyographical analyses that (a) it is possible to induce a nonlethal, exclusively sensory, reversible neuropathy by intoxicating rats with large amounts of pyridoxine, using a new schedule of intoxication; (b) 4-methylcatechol, a drug known to induce nerve growth factor synthesis, improves the clinical status of pyridoxine-intoxicated animals, shortens the duration of the disease, and restores the morphological integrity of the sensory fibers.
Gene_expression (synthesis) of factor in nerve associated with nerve growth factor, neuropathic pain, disease and poisoning
1) Confidence 0.67 Published 2001 Journal Neurobiol. Dis. Section Abstract Doc Link 11493027 Disease Relevance 0.59 Pain Relevance 0.12
We investigated the production of tumor necrosis factor alpha, a pleotropic cytokine, in the rat sciatic nerve using immunohistochemistry for the protein and in situ hybridization for specific messenger RNA sequences.
Spec (investigated) Gene_expression (production) of factor in sciatic nerve associated with necrosis, cancer, sciatic nerve and cytokine
2) Confidence 0.62 Published 1996 Journal Neuroscience Section Abstract Doc Link 8809782 Disease Relevance 0.57 Pain Relevance 0.14
Schwann cells produce tumor necrosis factor alpha: expression in injured and non-injured nerves.
Gene_expression (produce) of factor in nerves associated with necrosis and cancer
3) Confidence 0.62 Published 1996 Journal Neuroscience Section Title Doc Link 8809782 Disease Relevance 0.83 Pain Relevance 0.31
Schwann cells produce tumor necrosis factor alpha: expression in injured and non-injured nerves.
Gene_expression (expression) of factor in nerves associated with necrosis and cancer
4) Confidence 0.62 Published 1996 Journal Neuroscience Section Title Doc Link 8809782 Disease Relevance 0.83 Pain Relevance 0.32
This phenomenon is believed to be produced by a placental opioid-enhancing factor (POEF).
Gene_expression (produced) of factor associated with opioid
5) Confidence 0.58 Published 2000 Journal Physiol. Behav. Section Abstract Doc Link 10978472 Disease Relevance 0.10 Pain Relevance 1.20
Results demonstrated that in the uninjured sciatic nerve, few endothelial cells, fibroblasts, and Schwann cells were immunoreactive for tumor necrosis factor.
Gene_expression (immunoreactive) of factor in sciatic nerve associated with necrosis, cancer and sciatic nerve
6) Confidence 0.54 Published 1996 Journal Neuroscience Section Abstract Doc Link 8809782 Disease Relevance 0.80 Pain Relevance 0.20
Using immunocytochemistry in colchicine-treated rats, we showed that, in the lateral subdivision of the central amygdaloid nucleus and in the dorsal part of the lateral bed nucleus of the stria terminalis, a population of GABAergic neurones is able to co-synthesize either corticotropin-releasing factor or methionine-enkephalin, but never both peptides.
Gene_expression (synthesize) of factor in lateral associated with gabaergic and enkephalin
7) Confidence 0.53 Published 1997 Journal Neuroreport Section Abstract Doc Link 9376543 Disease Relevance 0 Pain Relevance 0.44
We present recent developments of this technique: In the SAS-tumour technique, vascular endothelial growth factor-producing tumour cells are inoculated subcutaneously directly on the membrane, and the formation of new vessels is measured 8 days later.
Gene_expression (producing) of factor in vessels associated with cancer
8) Confidence 0.52 Published 1999 Journal Pharmacol. Toxicol. Section Abstract Doc Link 9974188 Disease Relevance 0.51 Pain Relevance 0.09
Acrylamide (ACR) monomer produces neuropathy of the dying-back type and 4-methylcatechol (4-MC) is a potent stimulator of endogenous nerve growth factor synthesis.
Gene_expression (synthesis) of factor in nerve associated with nerve growth factor and neuropathic pain
9) Confidence 0.52 Published 1996 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8558436 Disease Relevance 0.56 Pain Relevance 0.12
Any factor producing an electroencephalographic arousal reaction leads to a narrowing of attention.
Gene_expression (producing) of factor
10) Confidence 0.52 Published 1975 Journal Pharmakopsychiatr Neuropsychopharmakol Section Abstract Doc Link 1233514 Disease Relevance 0.16 Pain Relevance 0.06
A native opioid peptide, [Met5]-enkephalin, termed opioid growth factor (OGF), serves as a constitutively expressed and autocrine produced inhibitory molecule related to developing, neoplastic, renewing, and healing tissues.
Gene_expression (expressed) of factor associated with enkephalin and opioid
11) Confidence 0.46 Published 1998 Journal Brain Res. Section Abstract Doc Link 9666142 Disease Relevance 0 Pain Relevance 0.53
Opioid growth factor-dependent DNA synthesis in the neonatal rat aorta.
Gene_expression (synthesis) of factor in aorta associated with opioid
12) Confidence 0.41 Published 1996 Journal Am. J. Physiol. Section Title Doc Link 8769781 Disease Relevance 0 Pain Relevance 0.71
To reveal roles of neurotrophic factors in plastic changes of the primary afferent neurons following nerve injury, we investigated expression of glial cell line-derived neurotrophic factor (GDNF) as well as nerve growth factor (NGF) in a neuropathic pain model of the rat.
Spec (investigated) Gene_expression (expression) of factor in nerve associated with nervous system injury, nerve growth factor and neuropathic pain
13) Confidence 0.40 Published 2003 Journal J. Med. Dent. Sci. Section Abstract Doc Link 12715924 Disease Relevance 0.54 Pain Relevance 0.59
To reveal roles of neurotrophic factors in plastic changes of the primary afferent neurons following nerve injury, we investigated expression of glial cell line-derived neurotrophic factor (GDNF) as well as nerve growth factor (NGF) in a neuropathic pain model of the rat.
Spec (investigated) Gene_expression (expression) of factor in nerve associated with nervous system injury, nerve growth factor and neuropathic pain
14) Confidence 0.40 Published 2003 Journal J. Med. Dent. Sci. Section Abstract Doc Link 12715924 Disease Relevance 0.55 Pain Relevance 0.66
The finding that expression of platelet-derived endothelial cell growth factor, which can activate mast cells, was lower in the bladder of responders than nonresponders indicates that bladder levels of platelet-derived endothelial cell growth factor may be a useful marker for this disease.
Gene_expression (expression) of factor in platelet associated with disease
15) Confidence 0.40 Published 2002 Journal Urology Section Abstract Doc Link 12007524 Disease Relevance 0.62 Pain Relevance 0.60
Expression changes of glial cell line-derived neurotrophic factor in a rat model of neuropathic pain.
Gene_expression (Expression) of factor in glial cell associated with pain and neuropathic pain
16) Confidence 0.31 Published 2003 Journal J. Med. Dent. Sci. Section Title Doc Link 12715924 Disease Relevance 0.54 Pain Relevance 0.77
Changes in neuronal activity were assessed by immunohistochemical analysis of expression of an inducible transcription factor (ITF), c-Fos, in the brain of rats habituated to repeated pentobarbital anesthesia or saline administration.
Gene_expression (expression) of factor in brain associated with anesthesia
17) Confidence 0.28 Published 2000 Journal Brain Res. Section Abstract Doc Link 10986339 Disease Relevance 0.09 Pain Relevance 0.51
Corticotropin releasing factor (CRF) injected intracerebroventricularly in doses from 15-150 pmoles (10-1000 nanograms) produced a prolonged locomotor activation in rats previously habituated to a test cage environment.
Gene_expression (produced) of factor
18) Confidence 0.28 Published 1985 Journal Prog. Clin. Biol. Res. Section Abstract Doc Link 3878524 Disease Relevance 0.06 Pain Relevance 0.19
We induced neuropathy in rats by means of ACR injection as an experimental model of the dying-back type of peripheral neuropathy to assess the potential efficacy of 4-methylcatechol (4-MC), a potent stimulator of endogenous nerve growth factor (NGF) synthesis, as a therapeutic agent for the axonal nerve lesion.
Gene_expression (synthesis) of factor in nerve associated with nerve growth factor, induced neuropathy, neuropathic pain and peripheral neuropathy
19) Confidence 0.27 Published 1995 Journal Neurotoxicology Section Abstract Doc Link 8584273 Disease Relevance 0.36 Pain Relevance 0.60
The antisecretory effect was not mimicked by atrial natriuretic factor, brain natriuretic peptide, or by putative antisecretory factors (neuropeptide Y, somatostatin, enkephalin, and norepinephrine), suggesting that cardiac antisecretory peptide is a unique regulatory factor that may regulate Cl transport in the intestinal mucosa and other epithelia.
Neg (not) Gene_expression (mimicked) of factor in brain associated with natriuresis, somatostatin, neuropeptide and enkephalin
20) Confidence 0.26 Published 1989 Journal Am. J. Physiol. Section Abstract Doc Link 2801925 Disease Relevance 0.20 Pain Relevance 0.28

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