INT43455

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Context Info
Confidence 0.11
First Reported 1980
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 4
Total Number 6
Disease Relevance 0.64
Pain Relevance 0.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

RNA binding (Pprc1) nucleus (Pprc1)
Anatomy Link Frequency
thoracic 1
Pprc1 (Mus musculus)
Pain Link Frequency Relevance Heat
anesthesia 22 98.68 Very High Very High Very High
agonist 60 88.12 High High
cINOD 3 68.60 Quite High
ischemia 3 58.96 Quite High
antagonist 7 5.00 Very Low Very Low Very Low
aspirin 4 5.00 Very Low Very Low Very Low
Perioperative pain 3 5.00 Very Low Very Low Very Low
Analgesic 3 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
Ultiva 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Renal Failure 9 77.76 Quite High
Anaemia 9 77.04 Quite High
Increased Venous Pressure Under Development 4 75.60 Quite High
Hemorrhage 6 65.84 Quite High
Pressure Volume 2 Under Development 18 64.64 Quite High
Cv Unclassified Under Development 3 58.96 Quite High
Syndrome 9 57.48 Quite High
Arrhythmia Under Development 6 56.32 Quite High
INFLAMMATION 4 55.08 Quite High
Heart Rate Under Development 6 49.08 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The study demonstrated reduced intraoperative PRC transfusion and less positive fluid balance in the "restricted fluid" group, while hematocrit values were not significantly different between groups at the end of the operation.
Negative_regulation (reduced) of PRC
1) Confidence 0.11 Published 2010 Journal J Cardiothorac Surg Section Body Doc Link PMC2845571 Disease Relevance 0.37 Pain Relevance 0.08
Recently, we published a RCT involving 130 pts operated for CABG under CPB supported by reinfusion of washed shed blood from thoracic cavities, and reported significant reduction of intraoperative PRC transfusions with a restrictive parenteral fluid protocol [9].
Negative_regulation (reduction) of PRC in thoracic
2) Confidence 0.11 Published 2010 Journal J Cardiothorac Surg Section Body Doc Link PMC2845571 Disease Relevance 0.14 Pain Relevance 0
137 of 192 patients received 289 PRC units in total.
Negative_regulation (received) of PRC
3) Confidence 0.11 Published 2010 Journal J Cardiothorac Surg Section Abstract Doc Link PMC2845571 Disease Relevance 0 Pain Relevance 0.09
Chronic renal denervation did not abolish the isoproterenol-pentobarbital synergistic effect on PRC.
Neg (not) Negative_regulation (abolish) of PRC
4) Confidence 0.06 Published 1983 Journal Ren Physiol Section Abstract Doc Link 6316431 Disease Relevance 0.08 Pain Relevance 0.29
Anesthesia resulted in a 3- to 5-fold rise in PRC, whereas saline expansion suppressed PRC at all ages, the fall tending to become progressively greater with age (P less than 0.09).
Negative_regulation (suppressed) of PRC associated with anesthesia
5) Confidence 0.05 Published 1980 Journal Pediatr. Res. Section Abstract Doc Link 6990367 Disease Relevance 0 Pain Relevance 0.10
exhibits a decreased ligand-binding affinity and decreased coactivator
Negative_regulation (decreased) of coactivator
6) Confidence 0.01 Published 2008 Journal PPAR Research Section Body Doc Link PMC2430035 Disease Relevance 0.06 Pain Relevance 0.18

General Comments

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