INT43459

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Context Info
Confidence 0.11
First Reported 1983
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 2.47
Pain Relevance 0.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Ltc4s) nuclear envelope (Ltc4s) lyase activity (Ltc4s)
endoplasmic reticulum (Ltc4s) nucleus (Ltc4s)
Anatomy Link Frequency
alveolar macrophages 4
Eosinophils 1
mast cells 1
Ltc4s (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cINOD 31 86.56 High High
aspirin 225 79.64 Quite High
Inflammation 9 49.24 Quite Low
alcohol 3 21.92 Low Low
corticosteroid 27 5.00 Very Low Very Low Very Low
antagonist 15 5.00 Very Low Very Low Very Low
Analgesic 15 5.00 Very Low Very Low Very Low
COX-2 inhibitor 9 5.00 Very Low Very Low Very Low
acular 6 5.00 Very Low Very Low Very Low
Paracetamol 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 13 88.48 High High
Asthma 393 82.20 Quite High
Pressure And Volume Under Development 9 74.88 Quite High
Nasal Polyps 48 65.44 Quite High
Polyps 3 34.48 Quite Low
Bronchospasm 18 5.00 Very Low Very Low Very Low
Rhinitis 18 5.00 Very Low Very Low Very Low
Syndrome 12 5.00 Very Low Very Low Very Low
Urticaria 9 5.00 Very Low Very Low Very Low
Hypersensitivity 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Kinetic studies revealed that ionophore stimulated the formation of mainly [3H]-LTE4 with only transient accumulation of [3H]-LTC4 and D4.
Positive_regulation (stimulated) of Positive_regulation (accumulation) of LTC4
1) Confidence 0.11 Published 1983 Journal Res. Commun. Chem. Pathol. Pharmacol. Section Abstract Doc Link 6316436 Disease Relevance 0.09 Pain Relevance 0.09
Eosinophils, mast cells, and alveolar macrophages use the enzyme LTC4 synthase to conjugate glutathione with LTA4 to make LTC4.
Positive_regulation (make) of Positive_regulation (enzyme) of LTC4 synthase in alveolar macrophages
2) Confidence 0.06 Published 2008 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2868885 Disease Relevance 0.79 Pain Relevance 0.14
Eosinophils, mast cells, and alveolar macrophages use the enzyme LTC4 synthase to conjugate glutathione with LTA4 to make LTC4.
Positive_regulation (make) of in Eosinophils Positive_regulation (enzyme) of LTC4 synthase in alveolar macrophages
3) Confidence 0.02 Published 2008 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2868885 Disease Relevance 0.79 Pain Relevance 0.14
Eosinophils, mast cells, and alveolar macrophages use the enzyme LTC4 synthase to conjugate glutathione with LTA4 to make LTC4.
Positive_regulation (make) of in mast cells Positive_regulation (enzyme) of LTC4 synthase in alveolar macrophages
4) Confidence 0.02 Published 2008 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2868885 Disease Relevance 0.79 Pain Relevance 0.14

General Comments

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