INT43479

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Context Info
Confidence 0.39
First Reported 1983
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 4.24
Pain Relevance 1.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CGA) small molecule metabolic process (CGA) extracellular region (CGA)
cellular nitrogen compound metabolic process (CGA) cell-cell signaling (CGA)
Anatomy Link Frequency
plasma 2
follicle 2
oocytes 2
CGA (Homo sapiens)
Pain Link Frequency Relevance Heat
narcan 13 99.98 Very High Very High Very High
antagonist 3 99.08 Very High Very High Very High
Pain 4 95.04 Very High Very High Very High
Clonidine 3 92.44 High High
Endogenous opioid 3 91.80 High High
Enkephalin 1 87.76 High High
Opioid 3 82.16 Quite High
agonist 10 75.00 Quite High
palliative 2 68.88 Quite High
Potency 1 66.68 Quite High
Disease Link Frequency Relevance Heat
Delayed Puberty 48 99.96 Very High Very High Very High
Reprotox - General 1 92 98.64 Very High Very High Very High
Hypogonadotropic Hypogonadism 31 97.56 Very High Very High Very High
Malignant Neoplastic Disease 3 89.36 High High
Cancer 18 84.32 Quite High
Obesity 3 76.72 Quite High
Congenital Anomalies 1 75.00 Quite High
Macromastia 1 74.72 Quite High
Aneuploidy 1 70.88 Quite High
Reprotox - General 3 5 65.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Naloxone caused a significant increase in luteinizing hormone (LH) (P less than 0.05); in these subjects, clomiphene treatment significantly increased LH and follicle-stimulating hormone plasma levels but totally suppressed the naloxone-induced rise in LH.
Positive_regulation (caused) of Positive_regulation (increase) of luteinizing hormone in plasma associated with narcan
1) Confidence 0.39 Published 1983 Journal Fertil. Steril. Section Abstract Doc Link 6317469 Disease Relevance 0 Pain Relevance 0.54
At referral 35 patients with CDP, including one GnRH failure, met the criterion for a positive response to HCG stimulation based on their own reactions (T > 170 ng/dl on day 3; > 200 on day 7).
Positive_regulation (response) of Positive_regulation (stimulation) of HCG associated with delayed puberty
2) Confidence 0.37 Published 2005 Journal J. Pediatr. Endocrinol. Metab. Section Abstract Doc Link 16279369 Disease Relevance 1.26 Pain Relevance 0
Forty-six male teenagers 13-19 years old with delayed puberty (DP) underwent gonadotropin releasing hormone (GnRH) and human chorionic gonadotropin (HCG) stimulation as part of their work-up.
Positive_regulation (underwent) of Positive_regulation (stimulation) of HCG associated with delayed puberty
3) Confidence 0.37 Published 2005 Journal J. Pediatr. Endocrinol. Metab. Section Abstract Doc Link 16279369 Disease Relevance 0.98 Pain Relevance 0
Normal circulating 17beta-oestradiol (E2) levels showed an enhanced response to human chorionic gonadotrophin (hCG) testing, which led to a reduced testosterone (T)/E2 ratio.
Positive_regulation (enhanced) of Positive_regulation (response) of hCG
4) Confidence 0.35 Published 2005 Journal Andrologia Section Abstract Doc Link 15644061 Disease Relevance 0.55 Pain Relevance 0.10
Forty-six male teenagers 13-19 years old with delayed puberty (DP) underwent gonadotropin releasing hormone (GnRH) and human chorionic gonadotropin (HCG) stimulation as part of their work-up.
Positive_regulation (underwent) of Positive_regulation (stimulation) of chorionic gonadotropin associated with delayed puberty
5) Confidence 0.32 Published 2005 Journal J. Pediatr. Endocrinol. Metab. Section Abstract Doc Link 16279369 Disease Relevance 0.98 Pain Relevance 0
Cryopreservation of mature oocytes after gonadotropin stimulation
Positive_regulation (after) of Positive_regulation (stimulation) of gonadotropin in oocytes
6) Confidence 0.04 Published 2008 Journal Breast Cancer Res Section Body Doc Link PMC2397531 Disease Relevance 0.07 Pain Relevance 0
Treatment with the antiandrogen induced a marked increase in gonadotropin levels, LH concentrations rising from a mean (SEM) of 17.5 +/- 1.6 to a maximum of 56.6 +/- 6.9 kU/l (p < 0.001), while mean testosterone and 17 beta estradiol-concentrations rose only by about 50% and 70% over pretreatment values, testosterone levels reaching a plateau after 1 month of treatment.
Positive_regulation (induced) of Positive_regulation (increase) of gonadotropin
7) Confidence 0.02 Published 1993 Journal Acta Endocrinol. Section Abstract Doc Link 8237249 Disease Relevance 0.40 Pain Relevance 0.18
Naloxone enhances angiotensin II-induced increase in serum luteinizing hormone concentrations in normal women.
Positive_regulation (enhances) of Positive_regulation (increase) of luteinizing hormone associated with narcan
8) Confidence 0.01 Published 1994 Journal Regul. Pept. Section Title Doc Link 8059012 Disease Relevance 0 Pain Relevance 0.56
Nine of these patients with normal basal serum FSH and 22 normal controls (five of whom had had a normal response to previous gonadotrophin stimulation) were prospectively subjected to: (i) transvaginal pulsed colour Doppler ultrasound evaluation of the vessels surrounding the dominant follicle for blood flow impedance analysis, (ii) the clonidine test to explore the ability of the pituitary to release growth hormone, and (iii) detection of anti-granulosa cell auto-antibodies in blood using an enzyme-linked immunosorbent assay (ELISA).
Positive_regulation (response) of Positive_regulation (stimulation) of gonadotrophin in follicle associated with clonidine
9) Confidence 0.00 Published 1994 Journal Hum. Reprod. Section Abstract Doc Link 7929726 Disease Relevance 0 Pain Relevance 0.09

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