INT43481

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Context Info
Confidence 0.19
First Reported 1983
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 1.36
Pain Relevance 0.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (ADRB1) plasma membrane (ADRB1) nucleus (ADRB1)
cytoplasm (ADRB1) signal transducer activity (ADRB1)
Anatomy Link Frequency
smooth muscle 1
ADRB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 8 99.96 Very High Very High Very High
Clonidine 2 93.32 High High
imagery 3 87.12 High High
Catecholamine 3 75.00 Quite High
addiction 9 21.52 Low Low
cytokine 6 5.00 Very Low Very Low Very Low
headache 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyperthyroidism 3 99.42 Very High Very High Very High
Hypertension 6 97.08 Very High Very High Very High
Hypertrophy 2 84.84 Quite High
Obesity 3 77.60 Quite High
Parasitemia 27 75.68 Quite High
Thyroid Disease 2 75.00 Quite High
Perinephritis 1 75.00 Quite High
Congenital Anomalies 2 70.00 Quite High
Malaria 123 58.64 Quite High
Pressure And Volume Under Development 1 50.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, thyrotoxicosis was accompanied by a 3-fold increase in beta 2-adrenoceptor number (P < 0.005), but unchanged beta 1-adrenoceptor levels.
Positive_regulation (increase) of 1-adrenoceptor associated with hyperthyroidism
1) Confidence 0.19 Published 1997 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 8989252 Disease Relevance 0.71 Pain Relevance 0.33
Since merozoites are the key inducers of ADRB activity, reproducible high throughput chemiluminescence analyses required access to ample supplies of suitable merozoite material.
Positive_regulation (inducers) of ADRB
2) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2845614 Disease Relevance 0.13 Pain Relevance 0
Importantly, this result confirmed that opsonized merozoites, even if permeabilized by freezing, mediate ADRB activity, and was a key condition for the technical feasibility of the assay.
Positive_regulation (mediate) of ADRB
3) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2845614 Disease Relevance 0 Pain Relevance 0.04
Freezing merozoite pellets, increased ADRB activity somewhat (Figure 1D), but antibody complexes with putative cytosolic antigens did not explain the increase, since merozoite sonication abrogated most ADRB activity (Figure 1D).
Positive_regulation (increased) of ADRB
4) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2845614 Disease Relevance 0 Pain Relevance 0.04
We believe the increased response to alpha 1-adrenoceptor agonists may be related to changes at a postreceptor site in the coupling of receptor activation to smooth muscle contraction.
Positive_regulation (increased) of 1-adrenoceptor in smooth muscle associated with agonist
5) Confidence 0.03 Published 1983 Journal Hypertension Section Abstract Doc Link 6317553 Disease Relevance 0.52 Pain Relevance 0.26

General Comments

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