INT43482

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Context Info
Confidence 0.60
First Reported 1983
Last Reported 2007
Negated 1
Speculated 0
Reported most in Title
Documents 4
Total Number 5
Disease Relevance 1.06
Pain Relevance 1.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

generation of precursor metabolites and energy (ADRB3) aging (ADRB3) plasma membrane (ADRB3)
nucleus (ADRB3) carbohydrate metabolic process (ADRB3) signal transducer activity (ADRB3)
Anatomy Link Frequency
thickening 2
ADRB3 (Homo sapiens)
Pain Link Frequency Relevance Heat
lidocaine 15 100.00 Very High Very High Very High
Mexiletine 8 99.76 Very High Very High Very High
agonist 56 96.28 Very High Very High Very High
adenocard 3 95.84 Very High Very High Very High
Clonidine 1 76.48 Quite High
antagonist 18 75.00 Quite High
Potency 1 40.44 Quite Low
Calcium channel 4 5.00 Very Low Very Low Very Low
Dismenorea 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypertrophy 2 99.54 Very High Very High Very High
Premature Birth 10 98.20 Very High Very High Very High
Congenital Anomalies 1 92.60 High High
Hypertension 6 80.84 Quite High
Perinephritis 1 75.00 Quite High
Pressure And Volume Under Development 1 74.64 Quite High
Obesity 4 5.00 Very Low Very Low Very Low
Pre-term Labor 4 5.00 Very Low Very Low Very Low
Dysmenorrhea 2 5.00 Very Low Very Low Very Low
Death 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On the other hand, high concentration (300 microM and 1 mM) of lidocaine, another class Ib antiarrhythmic drug, partially displaced the specific binding of [125I]cyanopindolol to human beta1-adrenoceptor, whereas it did not affect the specific binding of [125I]cyanopindolol to human beta2- and beta3-adrenoceptors.
Neg (not) Regulation (affect) of beta3-adrenoceptor Binding (binding) of associated with lidocaine
1) Confidence 0.60 Published 2004 Journal Biochem. Pharmacol. Section Abstract Doc Link 15104234 Disease Relevance 0 Pain Relevance 0.56
Is the beta3-adrenoceptor (ADRB3) a potential target for uterorelaxant drugs?


Regulation (potential) of beta3-adrenoceptor Binding (target) of
2) Confidence 0.45 Published 2007 Journal BMC Pregnancy Childbirth Section Title Doc Link PMC1892055 Disease Relevance 0.10 Pain Relevance 0.07
Is the beta3-adrenoceptor (ADRB3) a potential target for uterorelaxant drugs?


Regulation (potential) of ADRB3 Binding (target) of
3) Confidence 0.45 Published 2007 Journal BMC Pregnancy Childbirth Section Title Doc Link PMC1892055 Disease Relevance 0.10 Pain Relevance 0.07
Effect of pH and lidocaine on beta-adrenergic receptor binding.
Regulation (Effect) of beta-adrenergic receptor Binding (binding) of associated with lidocaine
4) Confidence 0.16 Published 1995 Journal Chest Section Title Doc Link 7587445 Disease Relevance 0.09 Pain Relevance 0.57
It could not readily be attributed to intimal thickening or hypertrophy of the arterial wall, altered basal levels of norepinephrine or epinephrine, changes in norepinephrine clearance, beta-adrenoceptor interactions, or decreased baroreceptor sensitivity.
Regulation (altered) of beta-adrenoceptor Binding (interactions) of in thickening associated with hypertrophy
5) Confidence 0.03 Published 1983 Journal Hypertension Section Abstract Doc Link 6317553 Disease Relevance 0.77 Pain Relevance 0.27

General Comments

This test has worked.

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