INT43483

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Context Info
Confidence 0.60
First Reported 1983
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 0.89
Pain Relevance 2.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (DLL4) signal transduction (DLL4) plasma membrane (DLL4)
Anatomy Link Frequency
endothelial cells 1
tail 1
embryonic kidney 1
DLL4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Enkephalin 17 100.00 Very High Very High Very High
agonist 19 99.28 Very High Very High Very High
addiction 1 99.20 Very High Very High Very High
tail-flick 2 97.32 Very High Very High Very High
opioid receptor 3 97.20 Very High Very High Very High
analgesia 2 96.88 Very High Very High Very High
antagonist 4 95.48 Very High Very High Very High
Calcium channel 6 92.44 High High
Pain 2 91.28 High High
MU agonist 1 75.00 Quite High
Disease Link Frequency Relevance Heat
Cancer 15 99.20 Very High Very High Very High
Drug Dependence 1 99.20 Very High Very High Very High
Pain 2 91.28 High High
Volume Depletion And Dehydration 2 90.60 High High
Hypoxia 2 68.16 Quite High
Tics 1 60.00 Quite High
Bordatella Infection 1 57.20 Quite High
Fibromyalgia 1 47.64 Quite Low
Pathologic Neovascularization 1 14.32 Low Low
Hematologic Neoplasms 14 12.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Dll4 is highly expressed by vascular endothelial cells and induced by VEGF [11].
Gene_expression (expressed) of Dll4 in endothelial cells
1) Confidence 0.60 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2902424 Disease Relevance 0.41 Pain Relevance 0
In this study, we expressed the two hdeltaOR variants in a heterologous expression system with an identical genetic background.
Gene_expression (expressed) of hdeltaOR
2) Confidence 0.54 Published 2009 Journal Traffic Section Abstract Doc Link 19000170 Disease Relevance 0.19 Pain Relevance 0.22
Alternative splicing of the alpha(2)delta-4 gene gives rise to four potential variants, a through d.
Gene_expression (splicing) of delta-4 gene
3) Confidence 0.51 Published 2002 Journal Mol. Pharmacol. Section Abstract Doc Link 12181424 Disease Relevance 0 Pain Relevance 0.24
We report here the identification of a novel alpha(2)delta subunit, alpha(2)delta-4, from the expressed sequence tag database followed by its cloning and characterization.
Gene_expression (expressed) of delta-4
4) Confidence 0.45 Published 2002 Journal Mol. Pharmacol. Section Abstract Doc Link 12181424 Disease Relevance 0 Pain Relevance 0.11
Incubation of human embryonic kidney 293s cells stably expressing h delta OR with the inverse agonist ICI174864 (1 microM) induced reciprocal changes in agonist and inverse-agonist binding.
Gene_expression (expressing) of h delta OR in embryonic kidney associated with agonist
5) Confidence 0.19 Published 2001 Journal Mol. Pharmacol. Section Abstract Doc Link 11562445 Disease Relevance 0.12 Pain Relevance 0.73
The delta Phe4-enkephalins have been synthesized and examined in an in vitro receptor binding assay and an in vivo tail flick analgesia test.
Gene_expression (synthesized) of delta Phe4 in tail associated with tail-flick, enkephalin and analgesia
6) Confidence 0.01 Published 1983 Journal Int. J. Pept. Protein Res. Section Abstract Doc Link 6317582 Disease Relevance 0.09 Pain Relevance 0.37
Synthesis and biological activity of delta Phe4-enkephalins.
Gene_expression (Synthesis) of delta Phe4 associated with enkephalin
7) Confidence 0.01 Published 1983 Journal Int. J. Pept. Protein Res. Section Title Doc Link 6317582 Disease Relevance 0.09 Pain Relevance 0.92

General Comments

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