INT43484

Context Info Confidence 0.37 First Reported 1983 Last Reported 2010 Negated 0 Speculated 1 Reported most in Body Documents 7 Total Number 9 Disease Relevance 3.22 Pain Relevance 0.95

nucleus (Runx2) DNA binding (Runx2) transcription factor binding (Runx2) cytoplasm (Runx2)

Anatomy Link Frequency chondrocyte 3 regulatory T cells 2 temporomandibular joint 1 Runx2 (Mus musculus)

Pain Link Frequency Relevance Heat Snapping jaw 5 98.80 antagonist 2 96.48 agonist 5 95.84 Osteoarthritis 182 82.72 Clonidine 2 80.28 depression 2 40.68 Inflammation 8 23.60 cytokine 12 5.00 cocaine 8 5.00 Spinal cord 6 5.00

Disease Link Frequency Relevance Heat Repression 16 100.00 Temporomandibular Joint Syndrome 5 98.80 Hypertrophy 16 98.20 Temporomandibular Joint Disorders 1 97.08 Systemic Lupus Erythematosus 64 96.96 Osteoarthritis 192 82.72 Disease 35 82.28 Targeted Disruption 16 81.68 Osteoporosis 7 72.28 Obesity 7 70.80

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Alteration of BMP-4 and Runx2 expression patterns in mouse temporomandibular joint after ovariectomy.

Runx2 Binding (Alteration) of in temporomandibular joint associated with snapping jaw

1) Confidence 0.37 Published 2007 Journal Oral Dis Section Title Doc Link 17305626 Disease Relevance 0.47 Pain Relevance 0.45

Napierala et al. 2005 reported two patients with promoter sequence variants and hypothesized that promoter mutations affecting binding of transcription factors critical for RUNX2 expression might change the transcriptional activity of the gene.

RUNX2 Spec (might) Binding (binding) of

2) Confidence 0.36 Published 2008 Journal American Journal of Medical Genetics. Part a Section Body Doc Link PMC2663417 Disease Relevance 0.19 Pain Relevance 0

Extensive deletion analysis [4], [6], [8] coupled with in vitro assays have established that amino acids (aa) 1–660 is sufficient to interact with MEF2, Runx2, HDAC1, 14-3-3, and also for phosphorylation and nuclear export [3], [12], [13], [16]–[19].

Runx2 Binding (interact) of

3) Confidence 0.29 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2720538 Disease Relevance 0.14 Pain Relevance 0

Therefore it is highly likely that the expressed HDAC4 1-747 retains its binding to and repression of MEF2C and Runx2 in vivo, explaining the lack of chondrocyte hypertrophy in our mutant mice.

Runx2 Binding (binding) of in chondrocyte associated with hypertrophy and repression

4) Confidence 0.28 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2720538 Disease Relevance 0.77 Pain Relevance 0

2; Runx2: Runt related transcription factor 2; Th17: T helper 17; TRAP: telomeric repeat amplification protocol; Tregs: regulatory T cells; TUNEL: Terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling; SHED: Stem cells from human exfoliated deciduous teeth; SLE: systemic lupus erythematosus; sRANKL: soluble receptor activator for nuclear factor ?

Runx2 Binding (biotin) of in regulatory T cells associated with systemic lupus erythematosus

5) Confidence 0.27 Published 2010 Journal Stem Cell Res Ther Section Body Doc Link PMC2873699 Disease Relevance 0.27 Pain Relevance 0

2; Runx2: Runt related transcription factor 2; Th17: T helper 17; TRAP: telomeric repeat amplification protocol; Tregs: regulatory T cells; TUNEL: Terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling; SHED: Stem cells from human exfoliated deciduous teeth; SLE: systemic lupus erythematosus; sRANKL: soluble receptor activator for nuclear factor ?

Runt related transcription factor 2 Binding (biotin) of in regulatory T cells associated with systemic lupus erythematosus

6) Confidence 0.27 Published 2010 Journal Stem Cell Res Ther Section Body Doc Link PMC2873699 Disease Relevance 0.27 Pain Relevance 0

Signaling via Smad1 cooperates with the transcription factor Runx2 (CBFA1) to induce chondrocyte terminal differentiation.

Runx2 Binding (cooperates) of in chondrocyte

7) Confidence 0.24 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875624 Disease Relevance 0.52 Pain Relevance 0.04

Signaling via Smad1 cooperates with the transcription factor Runx2 (CBFA1) to induce chondrocyte terminal differentiation.

CBFA1 Binding (cooperates) of in chondrocyte

8) Confidence 0.24 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875624 Disease Relevance 0.52 Pain Relevance 0.04

By comparison, alpha 2 receptors may exist in multiple-affinity states reflecting the ability of the alpha 2 binding site protein to complex to additional membrane proteins which themselves are receptors for the physiological substrates GTP, Na+, Mg2+, and possibly Ca2+-calmodulin.

alpha 2 binding site Binding (ability) of

9) Confidence 0.00 Published 1983 Journal Int. Rev. Neurobiol. Section Abstract Doc Link 6317599 Disease Relevance 0.07 Pain Relevance 0.42

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