INT43486

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Context Info
Confidence 0.69
First Reported 1984
Last Reported 2010
Negated 5
Speculated 7
Reported most in Abstract
Documents 52
Total Number 59
Disease Relevance 32.71
Pain Relevance 24.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ifng) extracellular region (Ifng)
Anatomy Link Frequency
macrophage 10
spleen 4
T cells 3
lymph nodes 2
lymphocytes 2
Ifng (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 365 100.00 Very High Very High Very High
cytokine 354 100.00 Very High Very High Very High
Inflammatory response 38 100.00 Very High Very High Very High
Dynorphin 27 99.76 Very High Very High Very High
narcan 24 99.72 Very High Very High Very High
Morphine 19 99.70 Very High Very High Very High
Paracetamol 47 99.62 Very High Very High Very High
rheumatoid arthritis 326 99.36 Very High Very High Very High
opioid receptor 22 99.36 Very High Very High Very High
withdrawal 6 99.04 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 388 100.00 Very High Very High Very High
Infection 31 99.96 Very High Very High Very High
Hepatotoxicity 23 99.92 Very High Very High Very High
Salmonella Infection 1 99.86 Very High Very High Very High
Immunization 8 99.82 Very High Very High Very High
Fever 7 99.78 Very High Very High Very High
Cancer 103 99.72 Very High Very High Very High
Cold Sores 3 99.72 Very High Very High Very High
Sepsis 64 99.60 Very High Very High Very High
Necrosis 30 99.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Subacute and chronic administration of nefopam induced no significant raise in the level of interferon-gamma (IFN-gamma) or in the level of total immunoglobulins in non-immunized animals, while subacute and chronic treatment with nefopam augmented markedly the immunization induced increase of level of interferon-gamma (IFN-gamma).
Positive_regulation (increase) of interferon-gamma associated with immunization
1) Confidence 0.69 Published 2007 Journal Int. Immunopharmacol. Section Abstract Doc Link 17178394 Disease Relevance 0.16 Pain Relevance 0.31
Subacute and chronic administration of nefopam induced no significant raise in the level of interferon-gamma (IFN-gamma) or in the level of total immunoglobulins in non-immunized animals, while subacute and chronic treatment with nefopam augmented markedly the immunization induced increase of level of interferon-gamma (IFN-gamma).
Positive_regulation (increase) of IFN-gamma associated with immunization
2) Confidence 0.69 Published 2007 Journal Int. Immunopharmacol. Section Abstract Doc Link 17178394 Disease Relevance 0.16 Pain Relevance 0.31
Furthermore, the protected mice, as compared to the unprotected ones, showed a significant (P<0.05) maximum increase in their serum nitrate and nitrite, interferon-gamma (IFN-gamma), and tumor necrosis factor-alpha (TNF-alpha) levels in their splenic homogenates, on the day before the beginning of the resolution of parasitaemia.
Positive_regulation (increase) of interferon-gamma associated with necrosis and cancer
3) Confidence 0.67 Published 2004 Journal Acta Trop. Section Abstract Doc Link 15158686 Disease Relevance 0.39 Pain Relevance 0.27
Furthermore, the protected mice, as compared to the unprotected ones, showed a significant (P<0.05) maximum increase in their serum nitrate and nitrite, interferon-gamma (IFN-gamma), and tumor necrosis factor-alpha (TNF-alpha) levels in their splenic homogenates, on the day before the beginning of the resolution of parasitaemia.
Positive_regulation (increase) of IFN-gamma associated with necrosis and cancer
4) Confidence 0.67 Published 2004 Journal Acta Trop. Section Abstract Doc Link 15158686 Disease Relevance 0.39 Pain Relevance 0.27
Subacute and chronic administration of nefopam induced no significant raise in the level of interferon-gamma (IFN-gamma) or in the level of total immunoglobulins in non-immunized animals, while subacute and chronic treatment with nefopam augmented markedly the immunization induced increase of level of interferon-gamma (IFN-gamma).
Neg (no) Positive_regulation (induced) of IFN-gamma associated with immunization
5) Confidence 0.50 Published 2007 Journal Int. Immunopharmacol. Section Abstract Doc Link 17178394 Disease Relevance 0.16 Pain Relevance 0.36
Subacute and chronic administration of nefopam induced no significant raise in the level of interferon-gamma (IFN-gamma) or in the level of total immunoglobulins in non-immunized animals, while subacute and chronic treatment with nefopam augmented markedly the immunization induced increase of level of interferon-gamma (IFN-gamma).
Neg (no) Positive_regulation (induced) of interferon-gamma associated with immunization
6) Confidence 0.50 Published 2007 Journal Int. Immunopharmacol. Section Abstract Doc Link 17178394 Disease Relevance 0.16 Pain Relevance 0.36
In this study, we used a murine cell line J774 of macrophage origin and examined the effect of dynorphin-A((1-17)), endogenous opioid peptide with selectivity for KOR, on NO release induced with lipopolysaccharide (LPS) plus interferon-gamma (IFN-gamma).
Neg (NO) Spec (examined) Positive_regulation (induced) of IFN-gamma in macrophage associated with dynorphin and endogenous opioid
7) Confidence 0.49 Published 2003 Journal Biomed. Pharmacother. Section Abstract Doc Link 14568229 Disease Relevance 0 Pain Relevance 0.69
In this study, we used a murine cell line J774 of macrophage origin and examined the effect of dynorphin-A((1-17)), endogenous opioid peptide with selectivity for KOR, on NO release induced with lipopolysaccharide (LPS) plus interferon-gamma (IFN-gamma).
Neg (NO) Spec (examined) Positive_regulation (induced) of interferon-gamma in macrophage associated with dynorphin and endogenous opioid
8) Confidence 0.49 Published 2003 Journal Biomed. Pharmacother. Section Abstract Doc Link 14568229 Disease Relevance 0 Pain Relevance 0.69
Dynorphin-A(1-17) decreases nitric oxide release and cytotoxicity induced with lipopolysaccharide plus interferon-gamma in murine macrophage cell line J774.
Positive_regulation (induced) of interferon-gamma in macrophage associated with dynorphin
9) Confidence 0.49 Published 2003 Journal Biomed. Pharmacother. Section Title Doc Link 14568229 Disease Relevance 0 Pain Relevance 0.55
ACTH and structurally related peptides were examined here for regulation of mitogen induction of the lymphokine gamma-interferon (IFN gamma) in C57BL/6 mouse spleen cell cultures.
Spec (examined) Positive_regulation (induction) of IFN gamma in spleen
10) Confidence 0.47 Published 1984 Journal J. Immunol. Section Abstract Doc Link 6317743 Disease Relevance 0 Pain Relevance 0.17
Phase I trial of adoptive immunotherapy of cancer patients using monocyte-derived macrophages activated with interferon gamma and lipopolysaccharide.
Positive_regulation (activated) of interferon gamma in monocyte associated with immunotherapy of cancer and cytokine
11) Confidence 0.47 Published 1998 Journal Cancer Immunol. Immunother. Section Title Doc Link 9439648 Disease Relevance 0.86 Pain Relevance 0.15
In this study we treated nine cancer patients with a total of 62 MAK infusion cycles with autologous macrophages given intravenously (i.v.) after in vitro activation with IFN gamma and LPS.
Positive_regulation (activation) of IFN gamma in macrophages associated with cancer
12) Confidence 0.47 Published 1998 Journal Cancer Immunol. Immunother. Section Abstract Doc Link 9439648 Disease Relevance 0.84 Pain Relevance 0.12
Spleen cells from mice undergoing withdrawal also had decreased splenic mRNA and/or protein levels of IL-1beta, IL-1Ra, TNF-alpha, IL-12, and IFN-gamma.
Positive_regulation (levels) of IFN-gamma in Spleen associated with withdrawal
13) Confidence 0.46 Published 2003 Journal J. Neuroimmunol. Section Abstract Doc Link 14597094 Disease Relevance 0 Pain Relevance 0.49
Importantly, the induction of genes involved in the inflammatory response (including iNos, gp91phox, and Fasl) and serum amounts of proinflammatory cytokines interferon-gamma (IFNgamma) and tumor necrosis factor alpha, which increase greatly with APAP challenge, are suppressed with manumycin A.
Positive_regulation (induction) of interferon-gamma associated with necrosis, paracetamol, inflammatory response, cancer and cytokine
14) Confidence 0.45 Published 2009 Journal Hepatology Section Abstract Doc Link 19739265 Disease Relevance 0.86 Pain Relevance 1.00
The inhibitory effects of morphine were not observed in T cells obtained from mu-opioid receptor knockout mice, suggesting that morphine modulation of IFN-gamma promoter activity is mediated through the mu-opioid receptor.
Positive_regulation (mediated) of IFN-gamma in T cells associated with targeted disruption, opioid receptor and morphine
15) Confidence 0.45 Published 2003 Journal J. Biol. Chem. Section Abstract Doc Link 12842891 Disease Relevance 0.16 Pain Relevance 1.05
To conclude suppression of IFN-gamma and increase in alpha-class GSTs expression may exert a protective role in acute hepatotoxicity of APAP and 5 kGy GIHA showed comparable protective effect to that of UIHA.
Positive_regulation (increase) of IFN-gamma associated with paracetamol and hepatotoxicity
16) Confidence 0.42 Published 2008 Journal Chem. Biol. Interact. Section Abstract Doc Link 18237725 Disease Relevance 0.31 Pain Relevance 0.28
Studies using neutralizing Abs indicated that elevated IFN-gamma and TNF-alpha were responsible for the exacerbated hepatotoxicity in SOCS3Tg mice.
Positive_regulation (elevated) of IFN-gamma associated with hepatotoxicity
17) Confidence 0.42 Published 2007 Journal J. Immunol. Section Abstract Doc Link 17339476 Disease Relevance 0.91 Pain Relevance 0.57
Altogether, these results suggest that forced expression of SOCS3 in T cells is deleterious in APAP hepatotoxicity by increasing STAT1 activation while decreasing STAT3 activation in hepatocytes, possibly through elevated IFN-gamma and TNF-alpha.
Spec (possibly) Positive_regulation (elevated) of IFN-gamma in T cells associated with paracetamol and hepatotoxicity
18) Confidence 0.42 Published 2007 Journal J. Immunol. Section Abstract Doc Link 17339476 Disease Relevance 0.52 Pain Relevance 0.26
ACTH and structurally related peptides were examined here for regulation of mitogen induction of the lymphokine gamma-interferon (IFN gamma) in C57BL/6 mouse spleen cell cultures.
Spec (examined) Positive_regulation (induction) of lymphokine gamma-interferon in spleen
19) Confidence 0.41 Published 1984 Journal J. Immunol. Section Abstract Doc Link 6317743 Disease Relevance 0 Pain Relevance 0.17
Also, peritoneal macrophages from C3H/Hej mice were stimulated with T. cruzi-derived GPI-mucin and/or IFN-gamma.
Positive_regulation (cruzi-derived) of IFN-gamma in peritoneal macrophages
20) Confidence 0.41 Published 1999 Journal Braz. J. Med. Biol. Res. Section Abstract Doc Link 10454743 Disease Relevance 0.40 Pain Relevance 0.33

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